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N&PD Moderators: Skorpio
I Like to Draw Pictures of Random Molecules
- Thread starter nuke
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pharmakos
Bluelighter
i don't think that much bulk on the phenyl ring will work out... (that is, guessing that you're trying to make something like a dissociative) who knows though.
SerotonergicHaze
Bluelighter
Yeah, I was hoping for a long lasting NMDA antagonist, perhaps one to utilize the other propitiates drugs like ketamine have such as low dose antidepressant effects. The N-iPR group would likely get cleaved off, and your left with this bulk chain, increasing lipophlicity. The fact it has a phenylethylamine backbone may make it more active at the NE sites, but I think it's lack of alpha substitution would mean it gets killed by MAO-A
I really need to put more thought into these, It's basically just drawing pretty pictures at the moment rather than drug design
pharmakos
Bluelighter
also, i believe you have an extra carbon atom between your rings in that molecule.
have you seen this thread? http://www.bluelight.ru/vb/threads/504286-PCP-analogs-(Cumulative)
sekio
Bluelight Crew
While we are on the topic of novel dissociatives & chemical masturbation, why have I not heard more on the potent NMDA-blocker etoxadrol & derivatives?
sekio
Bluelight Crew
I don't expect it to be very stable. Or fun.
There were, however, DMT analogues that look scarily like this in a recent Nichols paper.
sekio
Bluelight Crew
It's called "structure activity relationships", and many chemists spend their whole lives trying to figure it out. Start by reading PihKAL and TiHKAL by Sasha Shulgin, then read a bunch of David Nichols' papers too while you're at it.
Enix150
Moderator, MAPS Forums
^Phenethylamines only have two carbons before the nitrogen. It's not that you were wrong per se, it's just that when you're trying out several novel substitutions at once, it can get a lil confusing.
There is in CBN though.
Haha I smiled when I saw your bk-version, you definitely inspired pyr-αMT! Wish I could say more about it...
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Transform
Bluelight Crew
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- Sep 5, 2010
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Haha I smiled when I saw your bk-version, you definitely inspired pyr-αMT! Wish I could say more about it...
That's an interesting one. I expect it would be active.
Glenjih - your second one, based on the fact the n-methylated version is ok, would probably be ok too. http://www.erowid.org/library/books_online/pihkal/pihkal110.shtml
atrollappears
Bluelighter
How so? (That's a genuine question, not me being an asshole). Should it look like this instead?
I lifted most of the structure from bk-MDMA
Turns out that for an amphetamine to be active, it has to be basic, i.e., it has to be able to grab another hydrogen and put it on the nitrogen. Unfortunately, putting an electronegative fluorine near that nitrogen really limits the compound's ability to do that. So, this would probably not be active
Haha I smiled when I saw your bk-version, you definitely inspired pyr-αMT! Wish I could say more about it...
Hehe why thank you
Enix150
Moderator, MAPS Forums
^Actually, (and some of the ADD crew may disagree) I think that the molecules that don't work are the ones that I've learned the most from! Everytime someone posts an inactive structure here, it seems that everyone jumps on to teach us all why it won't work. The more "useless" ones that get posted, the more we subscribers to this thread get to learn!
On that note, I've wondered how 5-HTP analogs would be metabolized:
5-MTP ~ ~ ~ ~ ~ 4-HTP
atrollappears
Bluelighter
Not at all. I love blabbering about SAR stuff
Edit: By the way, most of the molecules we are drawing are just completely random crap. There's very little method to our madness, so don't be intimidated.
On that note, I've wondered how 5-HTP analogs would be metabolized:
5-MTP ~ ~ ~ ~ ~ 4-HTP
Try this one on for size
5-hydroxy-N-acetyltryptophan, possible precursor to the grand-daddy of endogenous antidepressants: N-acetylserotonin
http://en.wikipedia.org/wiki/N-acetylserotoninLast edited:
Enix150
Moderator, MAPS Forums
^Haha I like it! Being a huge proponent of psilocin, I always find myself hydroxylating the 4-position...
N-acetyl-4HT ~ ~ 4-hydroxy-N-acetyltryptophan
I was even thinking about going for 4-AcO-N-acetyltryptophan, but it seemed a bit.. ketotic.
EDIT:
N,N-DMTP
reEDIT: ^Or I guess not for that last one... www.cognitiveliberty.org/shulgin/adsarchive/dmt.htm
v4.0: ^Haha I spoke too soon, apparently its pharmacology remains untested! Also, take a look at these: http://en.wikipedia.org/wiki/Plakohypaphorine
Final Take: Tomorrow I want to start taking substitutions from various MTn-agonists to see how they'll fit on some phenethylamines, and maybe vice-versa?Last edited:- Status
