Be careful with those as they cause dependency extra quick. I've noticed after three days of continuous dosing, say 4 a day, my body becomes somewhat dependant. Enough so to make me want one the next morning. Space it out a bit. If its been that long, just a couple at once should do it depending on body weight. I've noticed though over time, even if I don't have any opiates for say a year, my tolerance is still not like it was when I had my first. I have Norco though and it has less apap. 7.5/325. I take three at a time a lot and the effects are great. Break em in haland down with grapefruit juice. Start drinking the juice about an hour before as it will potentiate the hydroce helps but I've noticed even with it, 2 doesn't do the trick. Anyway, be careful with it and space it out. apap is hard on the liver so stay below 3g, absolutely no more than 4g. You don't want to toy with that line.