How worthwhile is mephedrone?

[4DQSAR]

Some of the Russian bees actually seemed to enjoy this p-methylamphetamine, also known as p-TAP (para-tolylaminopropane)...

Yeah - we worked out that some genius had figured out that mixing p-TAP with plain amphetamine approximated MDMA - but was rather more dangerous. In Russia, people seem fearless when it comes to imbibing untested compounds. I don't know why, but injecting whatever drug they have seems to be a lot more common than elsewhere in spite of sterile works apparently being less available.

I've talked to a couple of HR workers who suspect Russia may have a much higher HIV infection-rate than is officially admitted to.

That the cathinone derivative doesn't appear to be anywhere near as toxic and actually MORE potent is interesting.

I keep pointing out that the para ethynyl homologe of mephedrone remains unexpored in spite of the fact that there is quite a lot of evidence suggesting that it would be as active as 4MTA in it's action BUT would be unlikely to have the dangerous MAOI activity.

 

[Rectify]

Very worthwhile, except for extremity vasoconstriction leading to blue body parts following heroic dosages.

 

[KetWise]

hexedrone is vastly superior to me.. I had mephedrone in 2010 and 3-MMC a bit more recently the latter is really disappointing for me. Mephedrone and ket snorted is crazy. shooting up hexedrone is massive mixed with ket or morphine its god like a lot more worthit than coke most of times

 

[rse]

I missed the boat with methedrone , is it still easy to get ?

Easy to get in Russia and Asian countries after 2022 Russian dark market poured off with the huge immigration waves into the Asian countries. Thailand, Indonesia (Bali), Vietnam, Georgia, Armenia, Kazakhstan, Ukraine, Israel, Dubai. Ofc for the foreigner it's might be hard to find, because they use dark market or telegram bots and not on the streets.

 

[KetWise]

Easy to get in Russia and Asian countries after 2022 Russian dark market poured off with the huge immigration waves into the Asian countries. Thailand, Indonesia (Bali), Vietnam, Georgia, Armenia, Kazakhstan, Ukraine, Israel, Dubai. Ofc for the foreigner it's might be hard to find, because they use dark market or telegram bots and not on the streets.

How interesting. I had no idea it was common in asia or middle east ! I guess many left and brought the drugs with them ... I saw the documentaries of people injecting and smoking it looks nasty as fuck . methcathinones give great rush but the crash is so hard it's basically how they end up in heroin after to handle the comedown.


IV brings the whole shit in another level .. Those cooks are fascinating me .. in the documentary meow meow russia..

It's fascinating how cooks find ways to synth drugs with so little .. The batches of NEH i've had in the end were smelling strong, was fucking caustic but stil IVed that..

It's a compulsive drug fiend, euphoric as MDMA speedy like meth, short as coke.. but cant focus on shit, great for partying I guess. Comedown is hellish . I dont see how people can only do this drug on its own you basically need proper downers to come down .

I fried my brain with both MDMA and NEH and im pretty sure the latter is harsher for the body and mind.

Fucking glad I dont shoot those things anymore it's hell on earth .. In my darkest days I would sometimes eat my morphine instead of IV it and only shoot NEH all day, my extremities getting cold, the psychosis insane .. makes you do stuff that you wouldnt do sober. Fiends would sell exchange anything for a point of it its an extremly moreish drug

 

[rse]

How interesting. I had no idea it was common in asia or middle east ! I guess many left and brought the drugs with them ... I saw the documentaries of people injecting and smoking it looks nasty as fuck . methcathinones give great rush but the crash is so hard it's basically how they end up in heroin after to handle the comedown.


IV brings the whole shit in another level .. Those cooks are fascinating me .. in the documentary meow meow russia..

It's fascinating how cooks find ways to synth drugs with so little .. The batches of NEH i've had in the end were smelling strong, was fucking caustic but stil IVed that..

It's a compulsive drug fiend, euphoric as MDMA speedy like meth, short as coke.. but cant focus on shit, great for partying I guess. Comedown is hellish . I dont see how people can only do this drug on its own you basically need proper downers to come down .

I fried my brain with both MDMA and NEH and im pretty sure the latter is harsher for the body and mind.

Fucking glad I dont shoot those things anymore it's hell on earth .. In my darkest days I would sometimes eat my morphine instead of IV it and only shoot NEH all day, my extremities getting cold, the psychosis insane .. makes you do stuff that you wouldnt do sober. Fiends would sell exchange anything for a point of it its an extremly moreish drug

I've tried to shoot almost all stims - meth, coke, meph, mdma. The worst are MDMA and Meth - better not shoot them at all. This drugs are more like teurapeutic drug then a recreational, despite the effecs. Can be used normally like took 1 time and have fun. But shooting - it's simply not made for it. And overall they had very bad recreational profile because of their invisible long lasting effects (MAOI ??? idk), when shoot it feels "short" but actually have cumulative effect in the brain. MDMA side effects includes brain zapps, depression and suicidal thoughts. The side effects will come days after. Not recommendend. Short cathinones (and coke) is compeletely different. Much more safer, However.

For the IV I have several rules out of my experience: Don't let dopamine, noradrenaline and sert level falls very fast. For the body it feels like you running for several hours and then immidiatly stop. I had expericenced artithmya lot especially from coke on comedowns.
1. Use Pregabalin 300-600 before session. It will reduce comedowns between the shots greatly. AND Greatly reduces risk of arithmya and seizure. Especially with coke.
2. Redose every 30m (for coke)-1h (for meph). Redosing will decrease risk of comedown side effects mentioned above. When I've just started I've done long pauses like 2h between the shots and it felt so bad.
3. Actually fap. IV is only for the fap. If you fap non stop, your noradrenaline level will be kept. It's funny but it reduces the risks, because you put your body on the extreme state and it needs some work to do. If you not give any work - your brain will rapidly dispose that insane amount of neurotransmitters - and you'll feel bad comedown almost instantly after 1h. If you exit smoothly (fap until effects worn off + use Pregabalin) you'll not feel any comedowns from any amount of shit done.

For the coke - if you use without anything (Lyrica) or smoke weed there is a high risk of seizure on high doses (150+). Actually better never go above 200. Sometimes you shot too much and start feeling OD and seizure is coming. You feel helicopters in the brain. Solution - do the series of the very deep breaths. Plus small fast ones in between. Like you do aerobics. Put hands in the air with the breathing. Walk. Run, took a lot of oxigen. This Immidiately stops seizure approach. Usually stops compeletely in 1-2 min after this breathing exercise. Ofc better not shoot coke a lot and fast, better do half, wait 20-30 sec push again if you not sure or use high dose. But better split in smaller doses ~125-150 and never go above. If want a lot better do 150 wait 10 min and do 150 again carefully.

For the mephedrone the problem is vasoconstriction and it makes blood thicker. If you lying on the bed and trying to stand - your brain will prob won't get enough blood and you can faint and fall on the ground. However, this thing never happens on coke. Possible solutions are - acetylsalicylic acid, magnesium supplements. But works not that great. If you do it, always keep it in mind. One time I fainted and broke some bones.

 

[Pissed_and_messed]

pregabalin can paradoxically decrease seizure threshold on high doses because it starts to increase glutamate levels at some point. YMMV. 150 mg probably increases seizure threshold for anyone but 600 and anything beyond then, well, might cause issues combined with other stimulant or serotonergic drugs. I have checked some anecdotal reports and some researches. Research unfortunately seemed very incomplete but there is some to support my statement.

 

[KetWise]

I've tried to shoot almost all stims - meth, coke, meph, mdma. The worst are MDMA and Meth - better not shoot them at all. This drugs are more like teurapeutic drug then a recreational, despite the effecs. Can be used normally like took 1 time and have fun. But shooting - it's simply not made for it. And overall they had very bad recreational profile because of their invisible long lasting effects (MAOI ??? idk), when shoot it feels "short" but actually have cumulative effect in the brain. MDMA side effects includes brain zapps, depression and suicidal thoughts. The side effects will come days after. Not recommendend. Short cathinones (and coke) is compeletely different. Much more safer, However.

For the IV I have several rules out of my experience: Don't let dopamine, noradrenaline and sert level falls very fast. For the body it feels like you running for several hours and then immidiatly stop. I had expericenced artithmya lot especially from coke on comedowns.
1. Use Pregabalin 300-600 before session. It will reduce comedowns between the shots greatly. AND Greatly reduces risk of arithmya and seizure. Especially with coke.
2. Redose every 30m (for coke)-1h (for meph). Redosing will decrease risk of comedown side effects mentioned above. When I've just started I've done long pauses like 2h between the shots and it felt so bad.
3. Actually fap. IV is only for the fap. If you fap non stop, your noradrenaline level will be kept. It's funny but it reduces the risks, because you put your body on the extreme state and it needs some work to do. If you not give any work - your brain will rapidly dispose that insane amount of neurotransmitters - and you'll feel bad comedown almost instantly after 1h. If you exit smoothly (fap until effects worn off + use Pregabalin) you'll not feel any comedowns from any amount of shit done.

For the coke - if you use without anything (Lyrica) or smoke weed there is a high risk of seizure on high doses (150+). Actually better never go above 200. Sometimes you shot too much and start feeling OD and seizure is coming. You feel helicopters in the brain. Solution - do the series of the very deep breaths. Plus small fast ones in between. Like you do aerobics. Put hands in the air with the breathing. Walk. Run, took a lot of oxigen. This Immidiately stops seizure approach. Usually stops compeletely in 1-2 min after this breathing exercise. Ofc better not shoot coke a lot and fast, better do half, wait 20-30 sec push again if you not sure or use high dose. But better split in smaller doses ~125-150 and never go above. If want a lot better do 150 wait 10 min and do 150 again carefully.

For the mephedrone the problem is vasoconstriction and it makes blood thicker. If you lying on the bed and trying to stand - your brain will prob won't get enough blood and you can faint and fall on the ground. However, this thing never happens on coke. Possible solutions are - acetylsalicylic acid, magnesium supplements. But works not that great. If you do it, always keep it in mind. One time I fainted and broke some bones.

I always used pregabilne at the same time with benzos and opiates. I was addicted to shooting morphine with either coke, mdma, or cathinones daily for 2 years. Never fapped tho . glad its over

 

[Pissed_and_messed]

I always used pregabilne at the same time with benzos and opiates.

I am not telling you what to do, well, you told you don't do this anymore and you don't even say it is good idea, so it is not even necessary...

but Imma gonna just remind that combining all three without remarkable tolerance is strongly adviced against for anyone else browsing through the thread.

 

[love_child]

I tried some 3mmc today. It smells horrible and I felt absolutely nothing. Snorted two lines and it just burns my nose. Shitty

 

[Shinji Ikari]

Might not be 3-mmc then.

Could try eating it. 3mmc is a lot rollier when you swallow it.

 

[notsmokeymcpot42088]

Mephedrone is the BEST drug available. It's like better and more safe version of MDMA/Meth/Coke. Oh boy, when this came to Russia this instantly got number 1 drug in the market and wiped out shitty coke, E/mdma, meth, Heroin.

It's actually pretty strong and very safe at the same time. Actually impossible to overdose and it don't have any side effects after the binges, unlike MDMA overdose (brain zapps, depression, anxiety). It goes easy on you. You can actually use up to 2g of this shit alone in one day, and you won't feel any shit after.
I highly recommend to mix with the weed and K.
And yeah sometimes it's hard to get the boner on it, especially on higher dosages > 0.2g
But, it's very easy to get addicted and start to inject it, because it's too good.

Some people feel this way - lots of ppl do. Personally Bk-mdma was my jam. Some people sware by MDA. most by MDMA (Best PR team lol)

Personal preference?

Not a stim guy so mephedrone wasn't my bag but I could see other ppl digging it

 

[new2drugs]

Is it still around in the UK then?

 

[vash445]

BTW when Russian Hyperlab first went on-line, a Russian chemist listed the precursors they had. They had 'obtained' them and didn't have access to anything else.

If memory serves toluene and propanoyl chloride and toluene were in that list.

I'm almost certain they did make what later became commonly known as mephedrone. But at the time, the reports weren't great. The chemist was trying to find a novel stimulant and the reports noted that it seemed quite weak. I mean, I SUSPECT they knew of pyrovalerone and thought that a shorter alkyl chain version would be similarly active. As we now know, that isn't the case. Pyrovalerone is a selective DRI whereas mephedrone acts on all three of the monoamines related compounds act on.

The same person also made the 2-thienyl analogue of methamphetamine which, again, wasn't considered to be much good but later DID turn up as an RC.

But I have to say that I know of at LEAST six people who claimed to have 'invented' mephedrone. I tend to believe that the Russian researcher was the first but they weren't in the business of producing it in large quantities or selling it. They were only interested in testing out novel compounds. To the best of my knowledge, they never came forward to claim that they invented it. I guess at the time, nobody realized that the Chinese would be able to telescope the synthesis down so much that in bulk they could make it for something like $800/Kg (in fact, possibly less).

It's my opinion that the KEY reason mephedrone was THE RC for so long was simply the fact that on a per-dose basis, it was by far the cheapest.

Still waiting for someone to produce the para ethynyl homologue of mephedrone. I'm prepared to bet £10 that it will largely act as a serotonin releaser/reuptake inhibitor. HOWEVER, I also believe that the N,N-dimethyl and N-pyrrolidine homologues would be more balanced and if the chain-length is increased, it;'s overall potency will increase.

Something like this:

1 — Postimages

postimg.cc

Can people understand what I'm getting at? It appears from related compounds that a para ethynyl provides the most active serotonin releaser/reuptake activity. In the same range as a para thiomethoxy (as seen in RCs such as 4MTA). BUT unlike a para thiomethoxyl, a para ethynyl doesn't introduce MAOI activity. It's been noted that cathinones seem less liable to act as MAOIs than their amphetamine analogues. That benzylic ketone may well prevent such compounds from blockading the VMAT-2 transports.

Of course nothing is written in stone. They would still require careful exploration. But in the related compounds, a para ethtnyl demonstrated serotonin transport activity orders of magnitude higher than the para (pseudo)halo* and para alkyl homologues of the same compounds.

*Substituants such as trifluoromethyl and nitrile are commonly refered to as possessing pseudohalogen properties. I think Shulgin even made the para nitrile homologue of 2CB. There are medicines containing aromatic nitrile moieties. So although the idea of introducing a -CN group to a compound looks dodgy, it's only toxic if the CN- ion can be liberated as it prevents cellular respiration. I've always though it odd that people talk of hydrogen cyanide in hushed tones when carbon monoxide is actually a more potent toxin. Of course, for decades Europe used 'coal gas' which contained carbon monoxide, so my guess is that it's toxicity was played down.

4mmc was posted on the hive. Using pfed or efed I believe they turn it to methcathinone

4mmc is different

 

[vash445]

Is it still around in the UK then?

4/3 mmc is on the net especially UK gotta go darker and deeper

 

[4DQSAR]

4mmc was posted on the hive. Using pfed or efed I believe they turn it to methcathinone

4mmc is different

4-methyl methcathinone (4MMC) isn't mephedrone?

I think it IS. I think anyone who understands organic chemistry knows that toluene and propanolyl chloride is the first step in 4MMC synthesis. But we are not allowed to discussed synthesis in detail so if you don't follow what I said, ask, I will explain.

Methcathinone is the not called 4MMC. It's simply called methcathinone. Methcathinone had been around for a LONG TIME before The Hive existed. Before the internet existed. Parke-Davis patented methcathinone and it's synthesis in 1957. US Patent 2802865 to be specific.

 

[fuckabout89]

I mean, mephedrone appeared in Russia around 2006-2007 and was legal, sold under the name "bath salts", before that it did not exist in Russia, Ukraine or Kazakhstan. Now the most popular substances in Russia are 4MMC and alpha-PVP. In the USSR, 4MMC did not exist

I bet you people were producing that shit in the 80s it just wasnt something that everyone got just the chemist who made it and for his friends. I know a lot of the cathiones were discovered in the 70s guarantee its been around longer than whats recorded online. Just something that wasnt mainstream then. The USSR had a lot more freedom regarding synthesizing anything you want, drugs were fround upon but who would know you made them and around that time ussr was already in its last days and the stalinists weren't fucking around with that shit in the early days of the soviet union.

 

[4DQSAR]

Yeah, diethylpropion (Tenuate/Amfepramone) was patented in 1961. US Patent 3001910 to be specific. Pyrovalerone (Centroton) followed soon after, Wander patented it in 1963. US 3314970 giving the details.

So even by the 1960s the QSAR of stimulant cathinones was quite well understood. I find it a bit odd that people seem to think that chemicals are randomly synthesized and tested. No, nature so often provides a protoype and rational design goes on to establish the QSAR. It's a bit scary to discover that things like 4CMC are now turning up. It's not as if they weren't known in the 1960s, they weren't developed into medicines for good reasons.

 

[vash445]

4-methyl methcathinone (4MMC) isn't mephedrone?

I think it IS. I think anyone who understands organic chemistry knows that toluene and propanolyl chloride is the first step in 4MMC synthesis. But we are not allowed to discussed synthesis in detail so if you don't follow what I said, ask, I will explain.

Methcathinone is the not called 4MMC. It's simply called methcathinone. Methcathinone had been around for a LONG TIME before The Hive existed. Before the internet existed. Parke-Davis patented methcathinone and it's synthesis in 1957. US Patent 2802865 to be specific.

4-methyl methcathinone (4MMC) IS mephedrone

I MIGHT BE wrong... But I'm just saying ... VERY DEBATABLE with a few people here

At the hive or otherwise... people with masters DEGREES OR DRS in chemistry say I KNOW MY SHIT

EVEN THEN. PEOPLE ON REDDIT GO DAMN VERY very few people go.. "SAYS DOESN'T KNOW SHIT ABOUT CHEMISTRY" PROCEEDS to GIVE DISSERTATION on the DANGERS OF AZIDES XD

Even then someone said who DOES hold a Dr degree, said I'm not saying I'm right or wrong. Just that, that the HYDRAZINE was made when the Azide got wet. And as the DEPT HEAD LITERALLY had to call BOMB CONTROL with a FLASK OF H2N4 or similar.




But methcathone IS NOT 4-methyl methcathinone (4MMC) IS mephedrone

methcathone is the OXIDATION of pusedo/efederine

Methcathinone is a schedule I controlled substance easily synthesized by oxidation of ephedrine or pseudoephedrine. Use of methcathinone peaked briefly in the 1990s, but has since declined; in large part due to stricter control of pseudoephedrine

4mmc IS NOT Methcathinone

Methcathinone (
) is a powerful psychoactive stimulant drug, acting as a norepinephrine and dopamine reuptake inhibitor. It is a controlled substance known for being highly addictive, similar to methamphetamine. Due to its high abuse potential and no recognized medical use, it is classified as a Schedule I substance, making it illegal worldwide.

Frequently referred to as "cat," "ephedrone," or "jeff," it is often produced illicitly from ephedrine or pseudoephedrine

This is Methcathinone

 

[vash445]

4-methyl methcathinone (4MMC) isn't mephedrone?

I think it IS. I think anyone who understands organic chemistry knows that toluene and propanolyl chloride is the first step in 4MMC synthesis. But we are not allowed to discussed synthesis in detail so if you don't follow what I said, ask, I will explain.

Methcathinone is the not called 4MMC. It's simply called methcathinone. Methcathinone had been around for a LONG TIME before The Hive existed. Before the internet existed. Parke-Davis patented methcathinone and it's synthesis in 1957. US Patent 2802865 to be specific.

4-methyl methcathinone (4MMC) isn't mephedrone?

I think it IS. I think anyone who understands organic chemistry knows that toluene and propanolyl chloride is the first step in 4MMC synthesis. But we are not allowed to discussed synthesis in detail so if you don't follow what I said, ask, I will explain.

Methcathinone is the not called 4MMC. It's simply called methcathinone. Methcathinone had been around for a LONG TIME before The Hive existed. Before the internet existed. Parke-Davis patented methcathinone and it's synthesis in 1957. US Patent 2802865 to be specific.

This is 4mmc



Anyways,.. I wanna BE THE FIRST PERSON HERE TO SAY..

I don't know shit. I at least more than most, and willing to say. I don't know or it is "theoretically a possibility"

Just even when a MD at a university labs says WE BOTH CAN BE CORRECT and maybe I missed this and THIS. really says something

Even one of my closer friends says, yeah you MIGHT KNOW YOUR SHIT, BUT HAVE YOU MET OUR FRIEND.... "BLANK"

"BLANK" works for one of the largest if not THEE LARGEST LEGAL HASH OIL / CONCENTRATION lab in the usa for white label.

I'm not gonna drop names. But if you seen these concentrates in store shelves they probably came from him.

This dude HAS A MASTERS in chemical engineering. First this dude WAS SHOCKED WHEN I could tell him the difference between

CHEMISTRY and chemical engineering... No BIG DEAL. This is someone who learned to break down the hive. No no.

The moment HE WAS FLOORED

was when I asked...

Oh a ENGINEER... MY best friend from elementary school worked at KELLOGG'S...

Have you SUCCESSFULLY completed a continuous FLOW. With HASH OIL MANUFACTURING and any and all telescopic procedures?

And he SAID HOW DO YOU EVEN KNOW WHAT THAT IS? BECAUSE NO, that is my litterly my day JOB, AND THE MAGNUS OPUS AWARD XD

"This yearly award recognizes an individual's achievements and contributions. Awardees demonstrate unparalleled skill, expertise, and dedication, resulting in significant advancements and a lasting impact."

I haven't been able to, I wanted to, and just said WTF DO YOU KNOW I DONT!

Anyways, 98% I see methcathone Vs mephedrone.

Granted I SPEED read a lot. So how was the 4 methyl tail added to Pfed of the benzene ring? Specifically on the 4 position,


If B HYDROXYL PUSEDO aka oxofirine or whatever is banned intentionally from the Olympics was used yeah aka p-hydroxy-pseudo-ephedrine)


( disguised and IMPROPERLY. so no-one can make any weird obscure analogues ,as that "tail" is there on said benzene ring along with the double bonded OH which is known cathone difference Vs Amphamine. And OK I get that maybe I'm too lazy to calculate and balance that with using HI to cleave or add whatever on said, "tail" on the benzene ring or the single bonded OH...

And I also ADMIT it's 100% easy to confuse
https://www.google.com/url?sa=t&sou...CFoQAQ&sqi=2&usg=AOvVaw1mwNawQ5gqNMiAyKIpqAe-
"Propylhexedrine aka NEW SCHOOL BENNIES " TO L meth in vicks inhalers maybe they were both meth AGES ago IDK not my time

But BENNIES are now 1-cyclohexyl-2-methylaminopropane

The difference is meth or MDMA has a BENZENE RING

BENNIES are a" polyhexadirine ring" so I'm told

Polyhexanide is part of the same pharmaceutical family as chlorhexidine, and is active against a wide range of bacteria.

benzene ring is a planar, hexagonal, six-membered cyclic hydrocarbon (
) characterized by aromaticity, where six carbon atoms share electrons in a delocalized system


The difference is, for me, "I'm a photo guy. Not a "nomenclature guy"

benzene ring has 3 lines inside, polyhexadirine has no lines

Just yeah know IDK, maybe I missed something, but idk how one would add, that "tail" to either P or Efederine

I mean I have an idea... Halogenation of Benzene or similar etc etc (BEING EXTREMELY VAGUE HERE)

Just IDK man, SEEMS EASIER TO TURN (in my head)

B HYDROXYL PUSEDO into 4mmc Turning the single bonded OH into a double bonded OH, then adding a methyl onto the 4 position of PUSEDO...

Hell it's probably easier to also turn it into "unregulated NPS" OR even regulated Meth before 4mmc..

Just know the "REAL THE MAGNUS OPUS AWARD the yearly award recognizes an individual's achievements and contributions. Awardees demonstrate unparalleled skill, expertise, and dedication, resulting in significant advancements and a lasting impact."

in regards to 4mmc was bestowed from rhodium to the OP of the FIRST mass produced communication (PS IM NOT OP Rhodium MENTIONED)



Rhodium
(Chief Bee)
04-05-03 01:16
No 423953
Congratulations!

I'm impressed! You have not only tested a new drug, you have also synthesized it yourself completely from scratch and written a textbook example of what a synthetic writeup should look like!

I hope that the trend I have noticed here during the last few weeks will continue, there has been several people posting typed journal articles, notes on practical laboratory procedures & equipment as well as more than one really nice post compilation digest (Those digests feels like a sort of "Hive Abstracts" if you ask me)