How worthwhile is mephedrone?

[4DQSAR]

Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Pro

Two chloromethcathinones, 3-chloromethcathinone (3-CMC) and 4-chloromethcathinone (4-CMC), and two para-substituted α-pyrrolidinophenones, 4-methoxy-α-pyrrolidinopentiophenone (4-MeO-PVP) and 4-fluoro-α-pyrrolidinopentiophenone (4-F-PVP), represent synthetic cathinones, the second most...

link.springer.com

Unstability of 4-CMC in human serum specimen - Forensic Toxicology

link.springer.com

https://onlinelibrary.wiley.com/doi/full/10.1002/hup.2621

It's a bit worrying that whomever is producing para halogenated homologues of mephedrone failed to note that one of the key virtues of mephedrone is that the para methyl is labile i.e. the body will oxidize that methyl so the metabolic pathway is quite simple. I forget the precise value but studies suggested that something like 90% of any dose of mephedrone will follow that single, simple metabolic pathway.

Halogens aren't quite as obliging. They can't be oxidized, they make hydroxylation anywhere else on the aromatic difficult so there are several competing pathways. Often which pathway dominates has a genetic basis.

I suppose it's just another example of when a ligand comes under legal control, it's usually replaced by something worse. After the US cracked down on almost all prescribed opioid medication, there was a huge gap in the market which fentanyl filled in spite of being markedly different to any of those prescribed medications AND more hazardous. Now that China has begun to tighten the laws surrounding the supply of fentanyl precursors, we see nitazenes turning up. I have no doubt that things such as 4-phenylphenapromide will surface at some point.

In an unregulated market, Grisham's law will always take over.

One of the reasons I suggested that a para ethynyl homologue was that unexpectedly, they CAN be oxidized. Or, more correctly, can undergo hydration. The product being an acetophenone which can be excreted OR go on to be oxidized further. Obviously very careful testing of the metabolism would be needed to validate that process, but aryl ethynyl moieties are used in many medicines so we do have a reasonable data-set to base this hypothesis on.

 

[Crash_ing]

Mephedrone is like MDMA. Wish I had some.

 

[4DQSAR]

Mephedrone is like MDMA. Wish I had some.

People bang on about who 'discovered' mephedrone. It's all rubbish. Mephedrone is covered by US Patent 3314970 from 1967. So unless the person claiming the credit made it BEFORE 1967, they are simply liars. 'rediscovered' or 'first to test subjective effects' or even 'first to scale up synthesis and sell as an RC' are all fine. But discovered? No. Some people just feel that need for external validation. Which is a bit sad.

MDMC was almost certainly discovered by Shulgin and almost certainly because he had read the above patent but mephedrone itself isn't new.

 

[vanbc27]

Mephedrone is not what you think. Any experienced drug user knows the faults of a drugs as well. MANY cases of people turning blue in the face and legs and arms because of lack of oxygen to blood. Very scary stuff. Just stick with 2-CB instead. Musch better high (3 peaks not just one like every other drug). Mephedrone though...it isnt worth the rick. Thats the summary I came to anyways with my years of research.

 

[fuckabout89]

Mephedrone is not what you think. Any experienced drug user knows the faults of a drugs as well. MANY cases of people turning blue in the face and legs and arms because of lack of oxygen to blood. Very scary stuff. Just stick with 2-CB instead. Musch better high (3 peaks not just one like every other drug). Mephedrone though...it isnt worth the rick. Thats the summary I came to anyways with my years of research.

Many people have heart attacks from cocaine quicker than others you should never try cocaine. Not everyone is gonna have that experience lots of people enjoy it. If your legs and face are turning blue from mephedrone from a one time try and your not taking copious amounts your body was in trouble before you took the drug.

 

[4DQSAR]

Mephedrone is not what you think.

2-methylamino-1-(4-methylphenyl)propan-1-one, CAS 2166915-02-0?

Mephedrone

Mephedrone | C11H15NO | CID 45266826 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

Certainly other compounds are being misrepresented as mephedrone. Is that what you refer to?

 

[Crash_ing]

In fact it's possible that MDMA pills are Mephedrone and Methamphetamine. Hence the MD and the MA.

There's a reason the crystals are pressed into tablets.

The sass people get now is just big mephedrone crystals.

 

[fuckabout89]

In fact it's possible that MDMA pills are Mephedrone and Methamphetamine. Hence the MD and the MA.

There's a reason the crystals are pressed into tablets.

The sass people get now is just big mephedrone crystals.

Or Di methylpentylone that will defiantly turn you blue and its been around since 2014. If you dont abuse it heavily though and smoke it its not as bad as taking it orally its basically useless snorting and boofing. Its whole another drug smoking it, makes me bing off the walls. You can put it under your tongue but it very caustic.

 

[fuckabout89]

To me, cathinones and pyrovalerones all feel like the same psilocin counterpart.

To me, cathinones and pyrovalerones all feel like the same psilocin counterpart.

People trash on the pentylone but its comparible to meth kinda if you do it right. I new a guy that washed it with different chemicals and tried different parts of the washed material it made it a lot better he said, wish I had the place for that though. Apparently 3f piph was good if you washed it, had a lot impurities in it that made people's kidneys hurt

 

[Crash_ing]

Sorry the pyrovalerones feel like the ephedrine derivatives

 

[4DQSAR]

Sorry the pyrovalerones feel like the ephedrine derivatives

As with all such things, YMMV.

As @fuckabout89 correctly notes, while a pathologist will state 'overdose' in cases where opioids are the primary cause of death, with cocaine, pathologists will list it as a factor in what turned out to be a fatal hear attack.

I've only seen it once, but at a NYE party in Amsterdam, the guy next to me railed a big line of coke off a speaker stack and collapsed. We spent 44 minutes trying to get a regular heart-beat back and carried on respiration and chest compressions. But it was NYE and the moment the paramedics arrived and performed and ECG, they told us to just give up.

Long-QT leading to torsades de pointes, shunting and finally sudden cardiac death.

But WE did not give up. We broke a couple of ribs but that isn't uncommon. We just kept ensuring oxygenated blood was still circulating. But the paramedics KNEW that even with our work, it was far too late.

Step 1 - get the time when you begin providing emergency medicine. That's why I said 44 minutes rather than 45. First thing we asked was for a time-check.