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How toxic is Mephedrone?

vecktor said:
there are a couple of general rules:

cathinones usually metabolise to the betahydoxy compounds.

the betahydroxy phenethylamines/amphetamines with a given substitution on the ring have much greater peripheral activity than the related amphetamines

PMA and PMMA cause spectacular rises in BP through vasoconstriction and their effect on the heart and have killed more than a few people

ergo these cathinones are a bad idea.

I really don't understand the logic of your post. how would such a vague concept as fierceness correlate to anything, in the same way how can you feel neurotoxicity. PCA in human trials was a nicely smooth anorectic, the fact it was ablating serotonin neurons. Aminorex and dexfenfluramine are likewise smooth but can do severe cardiovascular damage to people
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4-methylamphetamine is nasty stuff, hence my concern about 4-MMC from the day it appeared
 
hamhurricane said:
do you have a link to the human PCA trials? i would love to hear more information about that, was it really described as "smooth" or lacking in noticeable side effects? i understand the point your making is that neurotoxicity cannot necessarily be "felt" but still, i find that quite astonishing.
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the information is in most of the older books on AMP type compounds, and there is a paper where PCA was tested for anorectic activity in humans, where the( highly desirable) lack of peripheral sympathomimetic side effects was noted. if you search backwards through citations from the 60's papers on fenfluramine like I did you run into the papers on PCA.

If I get the time I will find the exact ref.

V
 
greetings,

While I have no real knowledge of chemistry, I guess like many people reading through this thread I have tried several other drugs like Mephedrone like mdma and various legal highs etc. So I may have a few insights people might find useful...

In around 48 hours we had approximately 2.0 of Mephedrone, and this is 1st time I have taken a large-ish dose of it - when I compare it to the effects/side-effects of everthing else I have to say that my impressions are good.

Now this might sound stupid to some, especially those approaching the subject from a purely scientific stance. But I think that your bodies reaction to a chemical is important and should not be ignored - very simple reactions like being sick are obvious signs that your body is rejecting what you have taken in - as is feeling nauseous when deciding to re-dose - there are many others. When taking anything i/legal be your own guinea pig, if you react badly to it, you should be making a decision at that point if taking it again is wise. |Eg. Eating magic mushrooms makes me gag and feel nauseous, but I will still take them every couple of years - but not frequently. And the legal high 'purple ohms' (BZP + other stuff...?) I will never go near ever again, purely because of how long it took me to right myself again after having it.

All that said, taking any drug regularly is just a bad idea - and it is worth assessing why you choose to do so (very different subject)

The discussion as to the few unusual and extreme reactions is not limited to unknown substances/illegal/recreational drugs. Look at the huge lists of possible side affects of prescription and over the counter drugs - ranging from mild irritations to death... while most people will have none at all - everyone is different and we all react to what-ever we put into our bodies differently (it seems I'm allergic to mint-sauce....)

Sorry about the rant, it is just my thoughts on the matter, and definately doesn't cover the whole subject - though to me it seems logical. I guess I'm just saying be responsible for yourself - you don't need a scientific study to tell you that something is bad for you, you can do that yourself.
 
^ No, that's actually a very good post. The original (and recurrent) intent of BL is Harm Reduction, and your post is an excellent example of such.

Sadly, many people who post this, especially ones on stims, forget about the whole Harm Reduction thing. It's good to see points of view like yours.

---

As for the thread itself... Mephedrone actually seems like a very tempting drug, but I wouldn't even touch it with a 10-foot pole because it seems to be bad news. Worse news than Meth, that's for sure.
 
Oh,british veggies don't add mint sauce to their vegetables? Positive surprise here ...
 
vecktor said:
there are a couple of general rules:

cathinones usually metabolise to the betahydoxy compounds.

the betahydroxy phenethylamines/amphetamines with a given substitution on the ring have much greater peripheral activity than the related amphetamines

PMA and PMMA cause spectacular rises in BP through vasoconstriction and their effect on the heart and have killed more than a few people

ergo these cathinones are a bad idea.

I really don't understand the logic of your post. how would such a vague concept as fierceness correlate to anything, in the same way how can you feel neurotoxicity. PCA in human trials was a nicely smooth anorectic, the fact it was ablating serotonin neurons. Aminorex and dexfenfluramine are likewise smooth but can do severe cardiovascular damage to people
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OK. Thanks.

Well, I think I can feel vasoconstriction and high blood pressure, and also usually feel the rise in body temperature from serotonergic drugs, but I might be entirely wrong.
 
When one takes this drug and their resting heart rate is about 120bpm (otherwise it's 60-70), is that something to be worried about?
 
Bob Loblaw said:
When one takes this drug and their resting heart rate is about 120bpm (otherwise it's 60-70), is that something to be worried about?
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i would say so

the problem i had with this drug was that i love the rush and the adrenaline feeling. i have become bored with it lately and the stale feeling afterwards. its addictive as hell and in reality the high isn't amazing anymore simply its just a carefree mong feeling and very compulsive. i simply cannot control my use and want to have my nose not cave in within a couple of years so my love of mephedrone has to end:\

as for not snorting it- once you develop an addiction to the act of snorting with one drug early in life you will always want to snort others.

the paranoia from this drug can be quite intense and the anger when you have been on a three day run quite excessive. all in all bad news, plus it smells of shit and makes people horny in a way that doesn't reflect their normal desires.
 
pofacedhoe said:
once you develop an addiction to the act of snorting with one drug early in life you will always want to snort others.
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I feel exactly the same when it comes to stims. The act of snorting is almost as rewarding as the effect. Kind of weird actually :\
 
For those of you who think that mephedrone should probably be avoided, what do you think about methylone? (especially because its also a relative of methcathinone)
 
MurphyClox said:
That's called "Pavlovian conditioning". Start barking NOW!
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tell me about it- i have seen two instances where female friends of mine where both moaning, " i want to stick something up my nose".

notice the word something... its not the drug its the pattern of pain followed by rapid mood elevation

SHNIFF:\
 
dread said:
In that case I hope you'll never try IV injections...
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My basis for never taking drugs this way - would make so many things far too addictive for my liking; anyway it would need another person to do it because I have a bit of a needle phobia (no honest!) surrounding seeing them enter flesh. Before anyone asks, you can IM a drug into your backside without the need to see the needle enter (just cover your whole arse cheek with isopropanol to give maximum target area, but be careful it doesn't reach your dangly bits or it hurts like hell ;D)
 
Bob Loblaw said:
When one takes this drug and their resting heart rate is about 120bpm (otherwise it's 60-70), is that something to be worried about?
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Yes, absolutely, that's pretty high. Though once on DOI my resting heart rate was like 100 or so, but it was hard to tell, it seemed to be going in step to the rhythm at the universe at that point, dancing in synchronization to the patterns on the wall.

But yeah, you could take some propranolol or something.
 
^Is that OTC?

What would be cardioprotective (or close to it) and OTC you guise would recommend most post-binge?
 
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