• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids How to increase the effects of opiates?

deroxor said:
I think your tolerance might be a major factor in the not being able to notice any effect from it. Honestly I diddnt notice much other than duration lasting slightly longer (but Methadone lasts along time anyways)
Click to expand...

It could be my tolerance. Anyway, I have to dose methadone twice a day, it doesn't last for me that long, it's 16 hrs at most and I'm feeling first withdrawal effects. Yet, I've gone down to as low as 10ml (1mg/ml syrup) in the morning and 10ml in the evening right now and I'm feeling "alright" when it's taken along with 5mg of clonazepam and 3mg of dexbrompheniramine.

laCster said:
have you ever tried tagamet with methadone?

on a side note, have you ever taken DXM on methadone?
Click to expand...

There are no medications with cimetidine in my country. And no, I have never taken DXM while being on methadone. It's a gross drug for me, even taking 2 tablets (= 30mg of HBr salt) makes me nauseous because of all these times when I threw up after taking DXM. Besides I'm getting enough unpleasant effects like restless legs, boneaches, headaches, insomnia and anxiety during tapering down and DXM might add some side effects to it (especially anxiety and restless legs). And it's completely different with ketamine, I've never thrown up after ketamine (but the pharmacodynamics differ ketamine is more of an NMDA channel blocker and sigma agonism plays a role at very high doses, with DXM it's actually opposite and this distinctive euphoria at lower doses like 300mg comes from sigma activation).

I might try drinking grapefruit juice on a regular basis and see if it has any impact on methadone metabolism, I'd be really glad if I could lengthen its half-life so I'm not all wet and cold waking up in the morning if I don't take the dose in the evening. :/ Not to mention I have terrible problems with falling asleep if I don't smoke some marijuana and I won't smoke every day for God's sake. :P
 
You must log in or register to reply here.
Top