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Opioids How to increase the effects of opiates?

I'm glad that this thread came up because I wanted to mention something without having to start my own thread. Has anyone here found that after taking a dose of opiates, exercise helps to increase the drug's effects?

I've been playing a bit of soccer lately because, strangely enough, my dealer likes to play soccer and sort of got me into it one day when we were just screwing around. But anyway, I had sniffed a couple of bags or whatever and then went outside to kick the ball around. For whatever the reason, I felt like the nod came on a bit stronger and the effects were altogether stronger or more noticeable. I imagine that it must have something to do with the whole "runner's high" thing, but I don't really know.
 
Benzoooooooos. Smoke some herb. For some reason, lying on the floor in the dark listening to some STS9, Radiohead or grunge makes my opiate high awesome, too.

And verso, I kind of get what you're saying. Last night I insuff'd twice and mainlined once, which for some reason wasn't cutting it. I went on a walk for about an hour and when I'd stop or anything, I'd feel a lot higher.
 
Drugs in general (but more specifically opioids) have more pronounced effects following physical activity because of endorphin release. I love banging some boy after a run or a little lifting, feels fucking good.

Anyway, OP there's a lot of good suggestions on here. Actually, shoving it up your ass WILL make the effects more pronounced, rectal bioavailability of most drugs is very high. But if that isn't your thing (it sure as fuck isn't mine), I'd recommend a different route of administration or smoking some pot.

Benzos & opiates go great together but can easily become a lethal combination.
 
Codeine p.r. and i.m. are actually equally better ROAs than p.o. (i.m. = 60% p.o.) but obviously it will take more time to absorb p.r. than i.m. so one gets a higher level of codeine in blood when it's i.m.'ed. You might consider this "codeine rush". However, if done incorrectly, swelling may appear, and you don't want to hit a vein because of massive histamine release and then heartbeat increases, BP decreases, a terrible headache appears and you're all red, especially redness appears in the spot where the vein was hit. It may turn out fatal. I know I wouldn't shove anything up my ass...

Centrally acting antihistamines are a better solution if you're looking for something non-addictive.
 
If you use the search engine there is plenty of info on this in the potentiation thread give it a look.
Always try the search engine before starting a new thread as you would have got more info than you did here and it keeps it less cluttered
 
amitriptyline (a tri cyclic anti depressant); and tagament. there is a thread about this in advanced drug discussion.

wikipedia
"Morphine is metabolized primarily into morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G)[31] via glucuronidation by phase II metabolism enzyme UDP-glucuronosyl transferase-2B7 (UGT2B7). About 60% of morphine is converted to M3G, and 6–10% is converted to M6G.[32] The cytochrome P450 (CYP) family of enzymes involved in phase I metabolism plays a lesser role."
 
I don't know if it's worth taking some pills for whatever disease so UGT1A3 and/or UGT2B7 are more busy metabolizing two drugs. I don't think the benefit is worth it but maybe for some people it's hard to get enough opioids so they want to prolong the high. Concerning morphine specifically, I liked smoking Atropa belladonna dried leaves (around 200mg of leaves) to boost the effects when I still shot up, in small doses atropine and scopolamine are sedating and in combination with morphine-like drugs they cause a great state of daydreaming (it's known as "Twilight Sleep"). Of course this doesn't apply to morphine only.

Now I often use dexbrompheniramine to boost methadone effects, especially because of low doses I'm on now (methadone + clonazepam + dexbrompheniramine and one can get pretty fcked up if doses are properly adjusted).
 
Cyclobenzaprine (AKA Flexeril) + Opiaites. Grapefruit juice can also have a prolonging effect on the duration (although ive never noticed a differance) And any Benzo's or Hypnotic home remedies you can get your hands on.
Gabapentine also potentiates the Opiate high, which ive mainly used in combination with Methadone.
 
white GFJ, tagamet, weed, benzos, mucle-relaxers, lyrica/gabapentin, anti-histamines (especially first genertion + other sedative anti-histamines), DXM, various 2D6/3A4 inhibitors and inducers, ect...
 
BHannon24 said:
If you use the search engine there is plenty of info on this in the potentiation thread give it a look.
Always try the search engine before starting a new thread as you would have got more info than you did here and it keeps it less cluttered
Click to expand...

This. Thanks bhannon

There are myriads of threads dealing with opiate potentiation. If you take a minute to utilize the wonderful search engine we have here on bluelight, you would have come across this - The Ultimate Opiate Potentiation Thread
 
Yeah, I don't get this thing with grapefruit juice. I'm not saying it doesn't potentiate anything, e.g. there's a research stating it might make methadone oral BA higher a bit drunk 30 minutes before ingestion and along with taking the dose. I've been constantly on methadone since Feb 09 and I've drunk liters of grapefruit juice (just because I like it, not for any potentiation). It doesn't do a thing. Also, I don't believe substances in grapefruit juice like bergamottin are capable of blocking CYP3A4 strongly.
 
^^
I think your tolerance might be a major factor in the not being able to notice any effect from it. Honestly I diddnt notice much other than duration lasting slightly longer (but Methadone lasts along time anyways) Also maybe a grapefruit is more beneficial to our potentiating cause than processed grapefruit juice. I wouldnt know though because i dont eat raw fruit, and havent experimented much with Grapefruit anyways.
 
adder said:
Yeah, I don't get this thing with grapefruit juice. I'm not saying it doesn't potentiate anything, e.g. there's a research stating it might make methadone oral BA higher a bit drunk 30 minutes before ingestion and along with taking the dose. I've been constantly on methadone since Feb 09 and I've drunk liters of grapefruit juice (just because I like it, not for any potentiation). It doesn't do a thing. Also, I don't believe substances in grapefruit juice like bergamottin are capable of blocking CYP3A4 strongly.
Click to expand...

have you ever tried tagamet with methadone?

on a side note, have you ever taken DXM on methadone?
 
I would stay away from potentiation with methadone, you don't really want to clog up the pathways that process it since it is (slightly) toxic (for an opiate) and having it not leave your body will just increase the risk of OD without significant recreational gains.
 
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