An important thing to consider is that if she's been taking sub for her habit and slips up for a bit of a binge, she waits a full couple days before taking the suboxone again. If not, she will be very, VERY sick. My cat, who already though she was in enough of a living hell, took it too soon and thought she was going to die. I'm talking shakily and sweatily hugging the toilet praying for sweet death Trainspotting style sickness. Many have taken pills the next day or two after sub and found only a mild decrease in the effects. The general rule is sub before pills, not so bad. Sub after pills (if one has a dependency), VERY bad. Be safe.