60mg hydrocodone, 1mg clonazepam, 0.5mg alprazolam
A special package may be at the post office this morning. If not, it will be there tomorrow.
What's inside should make me very happy.
What I intend to do when I get it may not be safe - I'll just take small doses at a time of the things I'm going to mix together so that I will hopefully feel if it is going to be a bad combo before I reach a really dangerous level.
This will involve 25C-NBOMe, MXE, 5-meo-mipt, bk-MDMA/Methylone, 5F-UR-144, 5F-AKB48, and MAM-2201. If I so desire, I may add something else to the mix but I probably won't. Mixing all that shit is probably going to be pushing it as it is, maybe too far.
Just wondering if anyone could answer this: would taking a dose of Ondansetron/Zofran to prevent nausea before the trip decrease the psychedelic effects? It is a serotonin recepter antagonist but is selective for the 5-HT3 receptor which I am pretty sure is not involved in the psychedelic effects of serotonin receptor agonists such as most psychedelics (the 5HT2 receptor is the important one).
I found this info
ondansetron exhibits detectable—albeit low affinity—binding to 5-HT1C, α1-adrenergic, and μ-opioid receptor sites [22].
I've found nothing about binding to 5HT2 receptors - maybe it has no effect on them. Does anyone know?
This is off topic, but Ondansetron seems to increase my ability to feel positive emotions even when I am depressed. I experimented with it for that purpose because it improves the negative symptoms of schizophrenia, which includes reduced ability to feel or express emotion. It seems like it may also have applications for depression related anhedonia. (My shrink is not sure whether I have bipolar disorder or schizoaffective disorder but says the depressive symptoms are my biggest problem). I don't think I have schizoaffective disorder because I have never had significant psychotic symptoms when not severely depressed or in a mixed episode and you must experience psychotic symptoms for at least two weeks in the absence of a mood disorder. I can get paranoid really bad if stressed out when I am not depressed and can have psychotic symptoms during panic attacks but most of the time I have no problem with that. I'll make a post about this in the mental health section as it is off topic here.
It may be useful for addiction from what I have read - I figure that may be of interest to some people here.
Edit:
Did not get here today - I guess I can wait until tomorrow to blast off.