VelocideX
Bluelighter
- Joined
- May 26, 2003
- Messages
- 4,745
MikeyFlowers said:The "holes in the brain" that are commonly refered to are called "Olney's lesions" and have never been proven or disproven to exist in humans. They've also never been associated with MDMA use even in animals (as far as I've ever known anyways) however people just love to say that something will put holes in your brain. After all, who really wants a hole in their brain?
Basically these are microscopic scars where a receptor site in your brain gets killed by the presence of a drug, a chemical released by a drug, or a transmitter becoming bound to a receptor it was never meant to bind to as the result of a drug. They have been shown (maybe? people will argue the validity of the study done) in lab animals exposed to very high doses of anaesthetics like DXM or ketamine.
Olneys lesions are associated with NMDA antagonist use, not serotonin agonists or serotonin reuptake inhibitors. MDMA doesn't cause them.