AlphaOdure
Bluelighter
Just thought i'd bring this new chemical to everyone's attention... i know it was discussed in one short thread in ADD but thats it. Anyways, in a nutshell- its called herkinorin; and its synthesized from salvinorin B, i think... The wiki article was sort of confusing, it says:
But interestingly enough, its about as potent an agonist at mu receptors as Salvinorin A is on kappa receptors (thats really strong, we're talking active doses in the high microgram range)! And it is 100x less potent at kappa opioid receptors compared to Salvinorin A. But even more interesting... herkinorin actually inhibits arrestin cellular uptake unlike every other mu-opioid agonist known (in short, arrestin is responsible for our current understanding of physical tolerance. Arrestin are indigenous, intracellular substances used by cells to quiet over stimulated electrical activity, they plug into neurotransmitter receptors that are overactive).
This basically means that herkinorin would produce little to no tolerance even w/ repeated or habitual use. But this could also imply herkinorin may be neurotoxic to opioidergic systems if there is no inherit means for the neuron to limit its own electrical activity. However, some of the medical community disputes the fact that arrestin's intracellular action is soley responsible for the mechanism of tolerance and that we do not understand the full spectrum and pharmacology of tolerance. Arrestin no doubt plays a major role in physical tolerance, but to what extent? We really don't know...
Some other side notes on the herkinorin- like the natural Salvinorin diterpenes, its unlikely to be active orally. IV injection is untested (probably works, solubility would be a factor though. I know there must be some problems with shooting diterpenes). Most likely active routes of administration that are minimally invasive (i.e.- not IV, IM, SUB) include sublingual (efficiency unkown) and smoking. If ever used recreationally, smoking would in all likelyhood be the most effective ROA; as diterpenes and terpenes can usually be smoked very efficiently.
Oh and btw, the drug is still LEGAL! Which means its only a matter of time before its sold as a research chemical; and then all scientific inquiry and investigation into this unique drug will be stopped once its scheduled.
http://en.wikipedia.org/wiki/Herkinorin
But thats bullshit. Salvinorin B is a naturally occuring diterpene thats found in 1Salvia Divinorum. I think the information is relatively new as the article cites studies done in 2005, so in time i'm sure it will be corrected, expanded, and refined. But anyways... we at least know its a semi-synthetic opioid (opioid in the pharmacological sense; in chemistry, its not really even a true opioid) made from salvia as opposed from opium.
But interestingly enough, its about as potent an agonist at mu receptors as Salvinorin A is on kappa receptors (thats really strong, we're talking active doses in the high microgram range)! And it is 100x less potent at kappa opioid receptors compared to Salvinorin A. But even more interesting... herkinorin actually inhibits arrestin cellular uptake unlike every other mu-opioid agonist known (in short, arrestin is responsible for our current understanding of physical tolerance. Arrestin are indigenous, intracellular substances used by cells to quiet over stimulated electrical activity, they plug into neurotransmitter receptors that are overactive).
This basically means that herkinorin would produce little to no tolerance even w/ repeated or habitual use. But this could also imply herkinorin may be neurotoxic to opioidergic systems if there is no inherit means for the neuron to limit its own electrical activity. However, some of the medical community disputes the fact that arrestin's intracellular action is soley responsible for the mechanism of tolerance and that we do not understand the full spectrum and pharmacology of tolerance. Arrestin no doubt plays a major role in physical tolerance, but to what extent? We really don't know...
Some other side notes on the herkinorin- like the natural Salvinorin diterpenes, its unlikely to be active orally. IV injection is untested (probably works, solubility would be a factor though. I know there must be some problems with shooting diterpenes). Most likely active routes of administration that are minimally invasive (i.e.- not IV, IM, SUB) include sublingual (efficiency unkown) and smoking. If ever used recreationally, smoking would in all likelyhood be the most effective ROA; as diterpenes and terpenes can usually be smoked very efficiently.
Oh and btw, the drug is still LEGAL! Which means its only a matter of time before its sold as a research chemical; and then all scientific inquiry and investigation into this unique drug will be stopped once its scheduled.
http://en.wikipedia.org/wiki/Herkinorin
Last edited:
