I received my sample today and, after an initial allergy test, have started trialling the compound. Bear in mind that I got a little bit less sleep than is preferable last night (about 4-5 hours), and that I had a coffee and ~20mg vyvanse this morning to wake me up for the day. I'm normally prescribed 50mg vyvanse/daily, however it's been about 5-6 weeks since I've last used any stimulants besides caffeine.
I dosed as follows:
(t+0h) 2:00: 8mg insufflated
As noted earlier in the thread, there was no burn and no significant taste upon insufflation. However a dull ache began to manifest in the sinus after some time. I would compare it to the "bruised" sensation you can get in muscle tissue after a tetanus shot (Or after any other fairly irritating IM shot, I would guess, though I have no experience with needles except medically). Overall, it went up the nose more pleasantly than any other compound I've tried except possibly MXE. It doesn't burn like fluorinated amps, EPH, etc., and it doesn't have a vile drip like tryptamines or APBs.
Within just a couple minutes I began to feel a sort of "fuzz" that I've come to associate with serotonergic drugs (not just SRAs, also SSRIs, DXM, and MXE--despite it's supposed lack of affinity for SERT). However I don't notice any entactogenesis. I also don't
feel any stimulation, though about 15 minutes after dosing I remember noticing that I no longer feel my sleep debt.
(t+0.5h) 2:30: 13 mg insufflated
The effects stopped growing about 15 minutes after dosing, so I waited another 15 minutes to be sure, and then measured out and insufflated a 13mg line. The same dull ache in the sinus returned--though it had never completely gone away from the last dose. I again noticed the serotonin-y buzz first, with the wakefulness emerging gradually over a few more minutes. The character of the drug becomes more apparent--I begin to suspect that it's dopaminergic push is too weak in comparison to it's serotonergic effects. However I decide that I'm enjoying the mild buzz I've developed, and ride it out for a while. I notice some tactile enhancement when I get up and walk around--the air feels good against my skin.
After about an hour, it starts to taper a bit. There's no comedown or urge to redose at all--at least at this point--just a gentle fading towards sobriety. However I decide to dose again in order to see where this compound can take me.
(t+1.5h) 3:30: 20mg insufflated
I take a 10mg line in each nostril. The ache in my sinuses isn't any stronger than previously, but the drip tastes a little more strongly with the greater quantity. I get the serotonergic fuzz again and start to feel a bit warm. I become a little concerned about the possibility of elevated body temperature and/or serotonin syndrome. However, this effect didn't grow any more obvious after the first couple of minutes.
A calm alertness begins to develop in me over the next 10-15 minutes, and I notice an inflation of ego--I feel generally
well. I first thought to describe this as a sensation of being
on top of the world. However, I don't think that's really appropriate given the subtlety of the feeling. Nevertheless I am enjoying myself at this dosage. It doesn't have the fiendish reward of EPH, or the bowl-you-over euphoria of 4-FA, or the warm glow of 5-APB, but it leaves me content and in the moment.
I do think to check my pulse, and am surprised to find it sitting comfortably at ~85bpm--EPH and MPH often set it racing, fluorinated amps seem to push it to 100+, and even my vyvanse tends to elevate it significantly. This drug certainly doesn't feel "tweaky" at all.
(t+2h) 4:00: 10mg EPH insufflated
The buzz is enjoyable but still mild, and I want to see how it develops. Thinking about my earlier conclusion that this compound is too serotonergic, and slightly wary from my earlier impressions, I decide to see if a more selectively dopaminergic stimulant can give it some legs. Though I start conservatively, in case of unexpected synergy, I quickly conclude that HDMP-28 does not hide EPH's physical side effects, andworry about spoiling the calm buzz by taking too much of a tweaky stim like EPH.
(t+2.3h) 4:20: 15mg HDMP-28 + 12mg EPH insufflated
I top off with a bit more of each, though by this time the effects had begun to wane--my earliest doses were probably well on their way to fading--so I mostly manage to extend the buzz rather than boost it. I definitely notice a greater degree of physical stimulation now than earlier, but I'm not uncomfortable.
I generally dislike taking stimulants via ROAs other than oral because of the abrupt comedown, and I find MPH and EPH comedowns especially hellish. Because of this I also added 10mg EPH and 10mg HDMP-28 to a bottle of gatorade, to sip on the rest of the night. The effects endured for another hour or two before starting to gradually fade away. As I write this at 8:00 (t+5.5h) the buzz is gone, but I'm still very awake. It's also obviously motivating this wall of text, though I feel significantly less of a desire to write now than I did upon starting this post half an hour ago.
Overall, I like this one's unique feel, though I didn't take it far enough to discover whether it can amount to more than a mild experience. However, the general lack of typical stimulant side effects bodes well for the scaleability of the high with increasing dose. I think next time I'll start off with two lines of 20mg, separated by 15-20 minutes. I also still think there's some merit in combining this with a more selective stimulant, though EPH isn't necessarily the right one.
Some notes:
I did not measure my temperature. I only came to a subjective conclusion that I felt hot and just slightly ill. However, given the total absence of stimulant anxiety, I'm pretty confident that I didn't imagine the sensation. Obviously, any serotonergic can be expected to affect body temperature to some degree, but serotonin syndrome is painfully unpleasant to experience (MXE and allylescaline... yuck!) besides being potentially fatal. It's worth noting that I did take tramadol two days ago, so it's possible that this was a minor interaction with any lingering metabolites. However, that doesn't bode well for this drug's interaction profile at all. Assume the worst: it might be as dirty as DXM. It should stay far far away from any SRAs, of course... but I would also be very cautious of interactions with regular amphetamine or SSRIs.
My product is a very finely ground, white, crystalline, powder. It doesn't clump or stick
at all. I
faintly detect a naphtha-like smell--possibly due to some remaining precursor or side product in the synth? However, I'm familiar with just how much naphthalene stenches, so I'm pretty confident that any impurities which may be present constitute a very small percentage of the material.
I also have a few thoughts to add on the potential for carcinogenicity or kindey/liver toxicity with this one.
Here is a MSDS for naphthalene. It has different toxicity and carcinogenicity characteristics depending on species and sex, however no
direct evidence of carcinogenicity in humans has been observed. Rats and female mice were more likely to develop certain types of cancers after inhaling naphthalene vapor at 10-60ppm for 6 hours a day, 5 days a week, for two years. This regimen doesn't cause cancer in male mice, probably due to differences in metabolism. Another experiment concluded that naphthalene's carcinogenicity could be explainable by it's partial metabolism into 1,4-naphthoquinone, which appears to suppress programmed cell death. This and other metabolites of naphthalene seem to be excreted rapidly into urine, with a biological half-life of just a couple of hours. I think the key here is consistency of exposure: While a worker in an unsafe plant might face daily environmental exposure to naphthalene--and therefore maintain a steady level of apoptosis-inhibition due to consistent blood plasma levels of its metabolites--intermittent exposure doesn't carry nearly the same set of risks, even if we assume that naphthalene or related compounds are significant impurities or metabolites of HDMP-28.
The larger issue IMO is the potential for organ toxicity, because we know that naphthalene can damage liver and kidney tissue, cause anemia, and promote the formation of cataracts. However, the LD50 for acute exposure is 2250mg/kg in rats, while the NOAEL (no observable adverse effect level) for chronic exposure is 100mg/kg/day in rats. Obviously, rats and humans are very different, but the FDA approximates dose equivalency between species in order to estimate "safe" exposure levels in humans. And the FDA claims that you could consume up to 0.1mg/kg/day of naphthalene every day for the rest of your life, or up to 0.4mg/kg in an acute exposure, and not experience any observable adverse effects. I weigh around 150lbs, so that means that I could eat 6.85mg of naphthalene every day, or 27.4mg of naphthalene on special occasions, and be "fine." Naphthalene weighs 128g/mol, while HDMP-28 weighs 283g/mol. This means that, if we are to assume the doomsday scenario that 100% of all HDMP-28 consumed is cleaved at the ring to form naphthalene, I should
hypothetically still be able to consume 15.2mg of HDMP-28 every day, or 60.8mg on rare occasions, without suffering any ill effects.
Lastly, there are symptoms of naphthalene poisoning which you can check out in the MSDS I linked. So at the very least, I doubt anyone is going to hurt themselves without realizing what's happening--that is, as long as they're sensible bluelight-reading, HR-practicing folk who research their vices and practice them in moderation. 0.0
EDIT: I'd forgotten that this thread was locating in NPD rather than OD. Sorry if any of this appears needlessly recursive, I was trying to spell out acronyms and explain terms as I used them.