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Grapefruit Juice MDMA Potentiation

Zalo

Zalo

Bluelighter
Joined
Oct 11, 2012
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Land of Glucose
Hey BlueLight,

I gave this question a search on google and could not seem to find a definitive answer.

I intend to candyflip at the end of the month (I'm so very excited). I read a rather informative post on reddit on how grapefruit juice can reduce the potential neurotoxicity induced by MDMA. The idea behind it is that the metabolite from MDA, which is a metabolite of MDMA, is what causes a lot of the neurotoxic damage. By inhibiting the enzyme, CYP3A4, that metabolizes MDMA to MDA with grapefruit juice it can potentially reduce neurotoxicity.

Anyways, I'm wondering to what degree does grapefruit juice potentiate the effects of MDMA? CYP3A4 is said to metabolize 10-15% of the MDMA, so I figured I'd take 10-15% less than I would normally for a candyflip.

Thank you.

For those interested: http://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neurotoxicity_part_1_metabolites/
 
A quick skim of the post you linked.. looks less like a potentiator and more like harm reduction.

I think instead of making your dose more potent, it will change how it feels to a degree and also likely help the comedown/recovery.
If grapefruit juice is responsible for increasing the enzyme that metabolizes mdma to mda; chances are you'll metabolizes more mda. Mda when taken directly is said to be more psychedelic which IMHO is probly better for combining with lsd anyways.

I could be completely wrong but this is my interpretation of the post.
 
The neurotoxicity of MDMA is poorly understand. But, it might change the high somewhat. It's difficult to predict what the metabolic change would actually cause subjectively. I'd probably just go for my usual dose and find out.
 
we've had a thread about that some time back. i looked it up back then and it turns out the people on reddit didn't get their facts right. it doesn't work that way (and mdma also is a potent inhibitor of cyp3a4 in itself, adding grapefruit juice would be pointless)

here is an earlier post i made on that subject (including literature to back it up).
 
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