Cosmic I've never had to go through withdrawals from it but I assume if my doctor ever wants to take me off that he'll wean me. Honestly, 90% of my meds are physically addictive so my Gralise is the least of my worries! It's the Methadone that freaks me out, although we lowered it from 50 MGS a day to 30 mgs a day so I feel better about that. Still, if I have to come off all this medicine it will not be easy.