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OD Moderators: Keif’ Richards | negrogesic
Benzos Gabapentin (Neurontin) and Benzodiazepines.
- Thread starter Thomas29
- Start date
Define huge.
Combining any two different CNS depressants will always be dangerous.
What dosage were you thinking of and what's your tolerance like?
Combining any two different CNS depressants will always be dangerous.
What dosage were you thinking of and what's your tolerance like?
jambabomba
Bluelighter
mm.. Gababentin is like pregabalin. I have been using pregabalin (wich is stronger than gababentin) together with benzos and phenibut sometimes very large doses but I wouldn't say it is safe. Ex. One time I gave my friend phenibut and he insisted he needs more because didn't beliebe that 2g would be enough for him because I was eating 10g of it + 600mg Lyrica + 4mg xanax + tramadol and was just fine to going to ex. work. So I gave him 3g but I was so overly worried that even though he hasn't took ANYTHING else I didn't sleep on that night but instead read and regularly watched that hes breathing was okey. He slept deeply about 12-16 hours!
Point is: It is all dependent of your tolerance. You could combine allmost anything if you take little amounts enough of everything. And as your tolerance grows you can combine larger doses. If you don't have tolerance to either gababentin or benzos DON'T try to combine them.
Point is: It is all dependent of your tolerance. You could combine allmost anything if you take little amounts enough of everything. And as your tolerance grows you can combine larger doses. If you don't have tolerance to either gababentin or benzos DON'T try to combine them.
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Gabapentin will make the benzos hit you like truck. It really isn't as dangerous as alcohol and benzos as gabapentin causes minimal cns depression.
Start out low as always, take and cur your doses in half for each...like if you usually take 1mg of xanax alone, take only .5mg with gabapentin.
Also know that benzos increase gabapentins bioavailability while decreasing the benzos bioavailability....usually I would take gabapentin allday and wait atleast 1hr after it to dose benzodiazepines
Yah it might not be the best hr advice to tell you it won't be bad to mix the two, but as long as to stick to low doses, don't drive, have someone watch over u during the experience and especially don't drink you should be fine.
The most important part is if you have a tolerance to both gabaprntin and benzos you should be fine, if you have never taken benzos or gabapentin, or if u have only tried one and not the other, don't take them together!
Start out low as always, take and cur your doses in half for each...like if you usually take 1mg of xanax alone, take only .5mg with gabapentin.
Also know that benzos increase gabapentins bioavailability while decreasing the benzos bioavailability....usually I would take gabapentin allday and wait atleast 1hr after it to dose benzodiazepines
Yah it might not be the best hr advice to tell you it won't be bad to mix the two, but as long as to stick to low doses, don't drive, have someone watch over u during the experience and especially don't drink you should be fine.
The most important part is if you have a tolerance to both gabaprntin and benzos you should be fine, if you have never taken benzos or gabapentin, or if u have only tried one and not the other, don't take them together!
in my experience gabapentin is a bit milder than pregabalin, but both substances amplify benzos all to fuck. it's a combination that can cause similar shit as mixing alcohol and benzos. if you know your limits it can be a good combination, but you have to be careful, careful, careful.
also gabapentin is not a CNS depressant to the best of my knowledge.
also gabapentin is not a CNS depressant to the best of my knowledge.
Yes I staggered my doses taking 300mg every hour until I reach the spot I want to be in...I'd wait atleast an hour after ur last gabapentin dose so it won't interfer as much with the bioavailability. Staggering neurontin is the best way to take it.
I'm not sure if waiting an hour after will help 100 ...but it definitely will help. I'd always get impatient and dose an hour after, and I wanted to still feel the gabapentin ...I'd always get too impatient and dose after an hour, but the longer the better. I say an hour because that's around the time u start to feel the gabapentin so I assume most is absorbed
I'm not sure if waiting an hour after will help 100 ...but it definitely will help. I'd always get impatient and dose an hour after, and I wanted to still feel the gabapentin ...I'd always get too impatient and dose after an hour, but the longer the better. I say an hour because that's around the time u start to feel the gabapentin so I assume most is absorbed
benzoheadplus44
Bluelighter
- Joined
- Feb 15, 2008
- Messages
- 317
shit i must have a tolerance i do all this plus bupe (well im out of bupe for a few days worried on that) daily and i toy with them but im also on dextrostat 80mg rxed 20 4 times a day but i take 120-150 idk anymore its not what it use to be,,, 300 lol.....
tyrael
Bluelighter
Hmm, interesting!
A question though, does the Gabapentin/Pregabalin potentiate benzodiazepines (directly? say via allosteric regulation?) or is it a synergistic-like effect?
Also, for those who've taken both Gabapentin and Pregabalin - what's your thoughts? Effects, (neg) side-effects, general efficacy, drug interactions (other then the obvious
) or time period/dosing regime?? I'm quite interested in this (and associated) drugs, considering Gabapentin is relatively new, the (known and possible) indications are extremely interesting! (imo)
(although maybe not a strong depressant) Gabapentin (and associates) are in fact classed as CNS depressants!
A question though, does the Gabapentin/Pregabalin potentiate benzodiazepines (directly? say via allosteric regulation?) or is it a synergistic-like effect?
Also, for those who've taken both Gabapentin and Pregabalin - what's your thoughts? Effects, (neg) side-effects, general efficacy, drug interactions (other then the obvious
) or time period/dosing regime?? I'm quite interested in this (and associated) drugs, considering Gabapentin is relatively new, the (known and possible) indications are extremely interesting! (imo)(although maybe not a strong depressant) Gabapentin (and associates) are in fact classed as CNS depressants!
jambabomba
Bluelighter
No. To my knowledge pregabalin acts only by modulating voltage gated calsium channels. Also it increases amount of GAD (glutamate acid decarboxylase) wich increases amount of GABA so indirectly it might enchance GABA signaling but not via allosteric modulation.
just looked it up, and you're right. i've just never noticed the slightest CNS depressant effects from either pregabalin or gabapentin.
gabapentin and pregabalin are supposed to have pretty much the same effects, but in my experience they don't. i've taken shitloads of both, and i think pregabalin has stronger anxiolytic properties while gabapentin has a more mood elevating effects. taken together, they actually compliment each other well.
one side effect i hate that only pregabalin seems to have is that in high doses it makes me tremble like fuck. that can be really unpleasant if you overdo it.
in regard to benzos, they both act pretty much the same, they amplify benzos to a considerable degree. i've found pregabalin to be very useful in keeping my benzo doses lower. i usually take it 1-1.5 hours before i plan on taking benzos. if you know how to dose it properly, it's a great combo.
tyrael
Bluelighter
Afai can tell, (not that I was disagreeing with you! ), ask you said xxxyyy I really can't see* any extensive differences between the two (on paper ![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
). Other then Pregabalin being the successor with a lower TI (read: dosing differences). Will be interesting what time tells, especially with Pregabalin and additional trails.
Cheers for the info guys!
* however like I said, my knowledge of these drugs really aren't too extensive yet
), ask you said xxxyyy I really can't see* any extensive differences between the two (on paper ). Other then Pregabalin being the successor with a lower TI (read: dosing differences). Will be interesting what time tells, especially with Pregabalin and additional trails.Cheers for the info guys!
* however like I said, my knowledge of these drugs really aren't too extensive yet
pregabalin/gabapentin are weird drugs, idk how to explain them, sometimes i feel energized, all the time i feel talkative on it. it does increase sedation of other drugs though (like benzos and opiates) even after being on it for a while, lyrica still gives me great anxiolytic effects, though i dont take it daily. i do love my lyrica, it's so versatile, it goes well with any drug, excluding psychedelics because i bet the hallucinations will be diminished by the pregabalin. i like it with weed, amphetamines, opiates, a little bit of alcohol (if you have a tolerance to lyrica), and various other stims and depressants.
if you want more on lyrica/neurontin, try the megathreads
if you want more on lyrica/neurontin, try the megathreads
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Thomas29
Bluelighter
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- Oct 25, 2010
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Sooo if it only effects orally logical common sense would be that 2 hours after ingesting GABAPentin should be COMPLETELY absorbed and will not fuck with the Benzos bioavailability. Than again I could be wrong some substances take a considerably longer amount of time to absorb hence I am making this post in case anyone has anything to say.