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  • BDD Moderators: Keif’ Richards | negrogesic

Opioids Full dose naltrexone for 6 days to produce sensitivity to opioids for 3-4 days

Juicewrldfan

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Dec 10, 2022
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Would this work? Trying to find an alternative to atoms. I don’t want to live completely abstinent.

So thinking kratom after day 6 on full dose naltrexone. I have seen the posts on ULDN but this is a bit different I would argue.
 
If you are dependent it will cause PAWS. If not, I mean, I don't see it being the worst thing ever, but you are the guinea pig, and if you don't wait until the Nalt is out of your system, you might waste the opioid. I'd say it's more efficiently used for ULDN.
 
You haven't given us much information.

Do you have a high tolerance to opioids in general or is it just kratom you have developed a tolerance to.

I think using naltraxone or naloxone to reverse opioid tolerance theoretically should work, but it's pretty unpleasant and I don't think the effect would be a total reset, more likely you would feel more from any opioid used directly after using the opioid antagonist but tolerance would quickly return to where it was at before using the antagonist.

I have accidentally experienced this very effect once, I have been on methadone for over 20 years so obviously my opioid tolerance is at a level that makes getting a pleasurable effect from any opioid very difficult even at very high doses.
So one day I got hold of a box of targine, 10mg oxy codone/5mg naloxone, I knew I would have to take pretty much the whole box but I thought I would start by popping half a dozen and I chewed them up as they were sustained release and I wanted instant obviously.

Well I hadn't done my research on naloxone and didn't realize that the sublingual bioavailability of naloxone is a lot higher than just swallowing it.

After about 15 minutes I was sweating, goose bumps all over and just started feeling totally shite, my nose started running and I couldn't stop yawning, at about the 30 minute mark I felt sure I was dope sick, so I managed to get on my pc and did some reading and quickly realized I had taken about 30mg of naloxone sublingually and had put myself into precipitated withdrawl.

Things continued to get worse, I was in full opioid wd, luckily for me the half life of naloxone is pretty short so after about an hour the experience began to change completely, by this time I had swallowed another 6 targin but of coarse I swallowed them straight down.

When the naloxone whore of I got an awesome effect from the oxy, it felt like strong opioids used to before I got on the methadone.

This is pure speculation but it was as if the naloxone had blasted the methadone off my receptors and then allowed the oxy to jump on and work their magic.

I would have thought that given methadone has a much longer half life than oxy codone that after the naloxone whore off the methadone would have just grabbed back on to the receptors but it did not feel like that at all, it absolutely felt like the oxy was the opioid that I was feeling.

The precipitated wd was so unpleasant I have never been game enough to repeat the experiment.

Anyway I realize this is a long post but maybe someone with more guts than me could try this theory out, make of it what you will.
 
The precipitated wd was so unpleasant I have never been game enough to repeat the experiment.

Precipitated WDs from naloxone is definitely one of those kinds of experiences: "Fucking hell, I am NEVER doing that again".

As for OP's experiment: I have no idea how that would work out but would be curious to know if OP ends up going through with it.
 
Precipitated WDs from naloxone is definitely one of those kinds of experiences: "Fucking hell, I am NEVER doing that again".

As for OP's experiment: I have no idea how that would work out but would be curious to know if OP ends up going through with it.
I have plans to after I finish my suboxone taper. Down to 2mg a day so after this week I’ll jump off and take comfort meds as needed (gabapentin, clonidine, zofran) I’m stacked with.

I’m going to wait ten days after my suboxone taper then initiate the naltrexone. There are papers that show that 50mg naltrexone taken for 6 days causes suprasensitivity to MU opioid receptors and for 3-4 days and then tolerance goes back to baseline what it was before. Now that’s if I’m reading them correctly. So this isn’t just a hypothesis I created.
 
This will definitely work but I recommend you start with ULDN and increase it as you can tolerate because it will definitely bring on PAWS if you take to much but you should be fine if you start at the 5mcg level and increase from there. Naltrexone will definitely reset you tolerance and there's actually a detox method that is performed with it that I went through many years ago. In that detox they started with 1/4 tablet of 50mg of 12.5mg and this definitely will put you in PAWS but it is tolerable. They would then increase this dosage over 5 days until you would pass the Naltrexone test which was taking a standard dose(50mg) and it no longer putting you in PAWS. At this point your opioid receptors have been cleared, your tolerance has been reset and they warn you of this when discharged but this program also keeps you on 50mg Naltrexone from that point on. If you're just looking to reset you tolerance this will work but be certain to NOT take your normal dose and return to a much lower dose or you'll risk an overdose as they also warn with this program.

I encourage you to read this thread as I will be following my most recent update with an update of me taking the ULDN on an increasing dose while abstaining from any opioids to reset my tolerance.
 
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