Opioids Finally ended oxy habit with ZERO withdrawals!!! SR-17018 is insane. Opiate withdrawal cure

[Syntherize]

May I ask how low you got on bupe before jumping off without withdrawal? I am down to like .7 mg's which I know is not low enough but the pill chopping is getting hectic / mg scale required almost

I was on a gram of real Heroin taken intravenously 2/3x per day a few years ago, and I waited approximately 36-40 hours before taking the Suboxone strips (8mg each). The first day I took 24mg, then I reduced my dose by 4mg per day until I got down to 12mg. At 12mg I immediately jumped down to 6mg once a day followed by tapering down by 1mg each following day after that until I got to 2mg. Apparently, according to the research 2mg is the average dose where our mu opioid receptors are still fully saturated, so at this dosage one must begin to move much slower. I was using the strips not the pills so it was easier for me to cut and dose them but I tapered the last 2mg of Suboxone over the course of two weeks (nice and easy taking a little off each day). If you have the old pills I would maybe suggest that you dissolve the pill in water and dose it volumetrically using an eye dropper or something for the same results. Just be sure to keep these tiny little doses under your tongue for at least 15-20min for maximum absorption because if you swallow it too soon you waste a bunch, but if you do this right you will be free too one day my friend without any PAWS or anything. Also, if you want you could always take a low dose (~5 grams) of some quality red vein kratom after the last day on Subs in order to help you reset a bit, but don’t just replace the Suboxone with the Kratom either since that can also be a slippery slope. If you need help with volumetric dosing feel free to search here on BL or ask me if anything because it isn’t difficult to do and it will be easier to keep track of your daily intake. Godspeed

 

[notsmokeymcpot42088]

you are correct it was real easy until 2 mgs -- i have the timeline in the tapering thread somewhere. Going from 2 to .7 took longer than going from 8 to 2 by a long shot.

Volumetric dosing is a good plan - dont know why I didnt think about it. I usually use ethanol for benzo's doing volumetric, so just water and I dont gotta worry about that goin bad in with 10 days --- fridgeration is alright im sure. If not tell me

 

[Syntherize]

you are correct it was real easy until 2 mgs -- i have the timeline in the tapering thread somewhere. Going from 2 to .7 took longer than going from 8 to 2 by a long shot.

Volumetric dosing is a good plan - dont know why I didnt think about it. I usually use ethanol for benzo's doing volumetric, so just water and I dont gotta worry about that goin bad in with 10 days --- fridgeration is alright im sure. If not tell me

I believe if you keep these buprenorphine solutions in water refrigerated it should keep pretty well for quite a while. The worst offenders for water based drug solutions are usually heat, sunlight, and too much oxygen, but I’m pretty sure Bupe is pretty shelf stable in water if I’m not mistaken. Try to use distilled water if possible for the best results.

 

[4DQSAR]

May I ask how low you got on bupe before jumping off without withdrawal? I am down to like .7 mg's which I know is not low enough but the pill chopping is getting hectic / mg scale required almost

Did you read the original 1971 protocol for buprenorphine in opioid detoxification?

I believe it was in the 1872 or 1973 'Annual Report of Medicinal Chemistry' and in essence the clinicians simply titrated the patient to a dose of buprenorphine that controlled the AWS. The patient was then allowed to stabilize on that dose for 7-10 days...

Then ALL medication ceased.

I think they wanted clients to be prescribed naltrexone to prevent them using but I can't remember if that was part of the protocol.

I can see the logic of 'parking' a client on buprenorphine but from what I read, if buprnorphine is prescribed long-term, it has it's own dependence issues.

 

[Kurt Cobain]

Hi all,

Long time lurker but I had to make an account to share my experience with SR-17018. I've been dependent on opiates for about 15 years, from oxy to subs to oxy to dills to subs to oxy. Tried to detox many many times but the mental game always caught me. When time slows to a crawl while you are in hopeless endless anxiety and depression. Just couldn't do it regardless of what method used.

Finally got my hands on the SR-17 a little over a week ago. Stopped my usual 300-400 mg of Oxy and started the SR-17. First two days I was definitely a little tired, occasionally hot/cold temperature regulation issues, felt very unmotivated and not myself but otherwise no acute withdrawal symptoms. By day 3, I felt completely fine, just felt sober. This is also when it seemed to do an amazing job curbing all of my cravings. It helped to stay busy so I'm not bored and thinking of doing drugs.

Anyway, for anyone having trouble kicking their habit, I highly recommend looking into the SR-17018. Took it for a week, and my last dose was 2 days ago, and I feel totally fuckin fine! I can't believe it honestly.

How did u feel agter those 2 days tho bc many report wds settling back in a day or two after sr cessation

 

[Kurt Cobain]

I am reading more stories about SR 17018 and they all say similar things. Honestly, it does sound too good to be true. Not trying to discount your (and others') story, but I'm a 'experiencing is believing' kind of person.

I have a similar situation to yours - 15 years of full dependence on a variety of opiates/opioids. I've had more failed detoxes than I can recall. The time dilation is crazy, isn't it? When you're in such a state of sheer agony (mental and physical), the minutes feel like hours, and because you cannot sleep at all, within a few days it feels like a never ending hell.



I'm also curious about this. The more info the better.

When you stopped taking it did you taper off or just stop? Were you taking anything else at the same time as the SR 17018? (e.g. clonidine, benzos, etc)?

Sounds like corporations trying to sell you a magic pill that doesnt exist

 

[Kurt Cobain]

Watching this thread. Kratom alkaloids and oxy ir and morphine er have been what I have been using.
I still get my Rx meds, and I used the Kratom alkaloids when I ran out of my Rx meds, but now I am fully aware of the need to taper down off the Kratom products.

Kratom is nit a morphine analogue like u said tho

 

[Dextro .45]

Methadone and Subs exist for opiate dependency but NOTHING exists for cocaine or meth addiction

Well for Cocaine addiction……agonist replacement therapy like Methylphenidate (Ritalin) XR long acting formula…..both drugs compete for same DAT and are nearly identical MOA

Meth or Amphetamines….they use Vyvanse (Lisdexamfetamine) 70mg usually

 

[4DQSAR]

Sounds like corporations trying to sell you a magic pill that doesnt exist

Well a couple of days ago I finally bit the bullet and took a proper look at the vendors. We KNOW that at high doses, SR17018 produce typical opioid-like effects. But these people were not always selling 'mystery powders', they were openly selling 30mg and 50mg tablets (in 3 tasty flavours FFS) so clearly they are relying on the safety paradox so people think 'I can catch a buzz without the physical dependence'.

Sad news - in sufficient doses SR17018 results in a classic opioid overdose (respiratory collapse) and in primate models and a few human reports, we see people taking the stuff for a joybang.

So while SR17018 may not be nothing, it's not that potent so it won't as they claim solve the problem for users of fentanyl and nitazenes, for example. They claimed it could but the doses stated were lies, the doses needed toxic. So it's bad that it becoming a schedule 1 drug makes research harder, but I always asked fans 'so, you KNOW the price will not increase and KNOW it will always be available'?

It's sad when it's the DEA who prove you right.

 

[Syntherize]

Well a couple of days ago I finally bit the bullet and took a proper look at the vendors. We KNOW that at high doses, SR17018 produce typical opioid-like effects. But these people were not always selling 'mystery powders', they were openly selling 30mg and 50mg tablets (in 3 tasty flavours FFS) so clearly they are relying on the safety paradox so people think 'I can catch a buzz without the physical dependence'.

Sd news - in sufficient doses SR17018 results in a classic opioid overdose (respiratory collapse) and in primate models and a few human reports, we see people taking the stuff for a joybang.

So while SR17018 may not be nothing, it's not that potent so it won't as they claim solve the problem for users of fentanyl and nitazenes, for example. They claimed it could but the doses stated were lies, the doses needed toxic. So it's bad that it becoming a schedule 1 drug makes research harder, but I always asked fans 'so, you KNOW the price will not increase and KNOW it will always be available'?

It's sad when it's the DEA who prove you right.

I have a friend who said he was smoking SR-17018 off foil for months and his respiratory system had suffered a lot of damage which in turn directly affected his ability to breathe properly smfh…

 

[Kurt Cobain]

I have a friend who said he was smoking SR-17018 off foil for months and his respiratory system had suffered a lot of damage which in turn directly affected his ability to breathe properly smfh…

Your friend is a fucking moron and you should find better friends. Im sorry but all the heinous shit i did and will continue to do in my active addiction i wouldnt fucking smoke a strange new mystery drug that i probably obtained from a sketchy vendor as is.

 

[Syntherize]

Your friend is a fucking moron and you should find better friends. Im sorry but all the heinous shit i did and will continue to do in my active addiction i wouldnt fucking smoke a strange new mystery drug that i probably obtained from a sketchy vendor as is.

Yep! and he’s not a close friend but more like an acquaintance. If you’re gonna do drugs I believe in doing real drugs and doing them properly as safely as possible. I’m not a crazy fan of RC’s, but I used to like MXE, 4-MMC, Methylone, and a lot of 2C’s back when they were all still legal.

 

[4DQSAR]

I have a friend who said he was smoking SR-17018 off foil for months and his respiratory system had suffered a lot of damage which in turn directly affected his ability to breathe properly smfh…

Obviously we have almost zero information in parethenral administration in man. I cannot recall if the primate study used parentheral administration but that's the closest we have to a human trial.

I just noted that the pKa of morphine is 7.8-8 so about 76% of it is ionized (i.e. cannot cross the BBB) at physiological pH.
I also checked and the pKa of SR17018 is 9.95-10.15 so only about 99.77% is ionized (i.e. cannot cross the BBB) at physiological pH.

Now as I understand it, if a drug in it's addition-salt form is vapourized, the addition salt is cleaved so your friend was breathing in hydrogen chloride. Decomposition can also take place but whatever the detail, it does rather suggest vaping is a TERRIBLE idea.

But was he at least spared any physical withdrawal symptoms? I suspect not but how severe I could not guess since I have no idea of the quantities and dose intervals. After all, while tolerance developed much slower in the primate model, it still occured.

That is the paradox of weak opioids. Clinicians focus so much on the risk of physical dependence and even addiction, they totally lose sight of the other toxic modes.

But to be clear, this is just a single unstructured case-study. The pKa values are solid as is the fact that vaping essentially 'freebases' the compound but is hazardous. Eveything beyond that is strictly a single example. I don't think there is a study in which the vapour was inhaled so cannot say if this is usual or unusual.

I'm a stickler for stating the limits of knowledge.

But if someone's basic argument is 'it did X and it worked for me', do consider that if the same drug killed others, the unucky one'd don't get to write responses syting 'I did X and it killed me' - this is called survivorship bias. Even in dilute forms, people will tend to overstate benefits if something works for them far more often than a person even stating it didn't work for them - especially when addiction is at play. Some people are just wired so addiction is more likely - it's not a character flaw, it's genetics and childhood experiences.

 

[Syntherize]

Obviously we have almost zero information in parethenral administration in man. I cannot recall if the primate study used parentheral administration but that's the closest we have to a human trial.

I just noted that the pKa of morphine is 7.8-8 so about 76% of it is ionized (i.e. cannot cross the BBB) at physiological pH.
I also checked and the pKa of SR17018 is 9.95-10.15 so only about 99.77% is ionized (i.e. cannot cross the BBB) at physiological pH.

Now as I understand it, if a drug in it's addition-salt form is vapourized, the addition salt is cleaved so your friend was breathing in hydrogen chloride. Decomposition can also take place but whatever the detail, it does rather suggest vaping is a TERRIBLE idea.

But was he at least spared any physical withdrawal symptoms? I suspect not but how severe I could not guess since I have no idea of the quantities and dose intervals. After all, while tolerance developed much slower in the primate model, it still occured.

That is the paradox of weak opioids. Clinicians focus so much on the risk of physical dependence and even addiction, they totally lose sight of the other toxic modes.

But to be clear, this is just a single unstructured case-study. The pKa values are solid as is the fact that vaping essentially 'freebases' the compound but is hazardous. Eveything beyond that is strictly a single example. I don't think there is a study in which the vapour was inhaled so cannot say if this is usual or unusual.

I'm a stickler for stating the limits of knowledge.

But if someone's basic argument is 'it did X and it worked for me', do consider that if the same drug killed others, the unucky one'd don't get to write responses sating 'I did this and it killed me'.

Thank you

 

[4DQSAR]

No problem.

I would be really interested to know if tolerance and dependence DID become issues.

After all, in the primate model it was compared with buprenorphine and found slightly less effective for detoxification purposes. Not nothing, just not some amazing trick to avoid AWS.

But claiming it works for things like fentanyl. Who knows? One thing's for sure, the pages I saw MAY have even been true - but edited down so the 99% of people for whom it didn't work were simply omitted.

If someone tells you something is 'too good to be true' or 'the hype is real' (an oxymoron) then believe them - they unwittingly told the truth. It ISN'T true.

I cannot police Reddit - a site where sockpuppet acounts can be set up in moments and people making unwanted observations can be downvoted OUT i.e. it's perfect for scammers!

 

[Syntherize]

No problem.

I would be really interested to know if tolerance and dependence DID become issues.

After all, in the primate model it was compared with buprenorphine and found slightly less effective for detoxification purposes. Not nothing, just not some amazing trick to avoid AWS.

But claiming it works for things like fentanyl. Who knows? One thing's for sure, the pages I saw MAY have even been true - but edited down so the 99% of people for whom it didn't work were simply omitted.

If someone tells you something is 'too good to be true' or 'the hype is real' (an oxymoron) then believe them - they unwittingly told the truth. It ISN'T true.

I cannot police Reddit - a site where sockpuppet acounts can be set up in moments and people making unwanted observations can be downvoted OUT i.e. it's perfect for scammers!

Agreed! And yes, Reddit is complete trash these days and a far cry from what it once was over fifteen years ago. I’ve never tried SR-17018, but I currently have a few friends that told me they stocked up on it prior to the ban in order to kick heroin and/or MGM-15. I’ve only ever tried methadone (10mg white pills) and Buprenorphine for opioid withdrawal. I never went through a program/detox or anything, so I always procured what I needed from my friends and designed my own taper to get off smoothly. I prefer Suboxone over methadone, but I will tell you that when most of the heroin here in the USA began being spiked with fentanyl analogs and God knows what it made it more difficult for me to induce the Buprenorphine. Back when it was all straight heroin I could take an 8mg strip after only waiting 12-16 hours after my last shot of dope, but once the fentanyl analogs came into the supply I noticed that even after waiting a full 24 hours I would get thrown into precipitated withdrawal. One of my knowledgeable buddies explained that fentanyl is more lipid soluble than heroin, so it gets absorbed into our fat cells in the body which means that one must abstain from doing a dose for 36-48 hours minimum before taking the Suboxone. I ended up waiting 38 full hours until I was well into feeling like shit, and I ended up taking 16mg of Suboxone which worked but the “transition” wasn’t as comfortable as it used to be for me in the past, and I’ve tapered off opioids too many times to count in my life. Maybe it is a type of kindling effect because of my repeated drug history, but either way it is kind of scary how nowadays the drugs are almost being designed to be very difficult to come off even when using the standard treatment options such as Suboxone or Methadone. I never messed with Nitazines and they scare the shit out of me, because I hear they are so potent that they basically fry a user’s opioid receptors making even super high (500mg+) doses of Methadone and/or Buprenorphine ineffective. Scary shit man…Godspeed.

 

[4DQSAR]

The same problem exists for buprenorphine. It simply isn't potent enough to substitute for fentanyl. It's affinity is lower so one a person's body has adjusted to fentanyl via homeostasis, there are't enough receptors left for it to substitute.

No idea about MGM-15 but the nitazenes are probably even worse because a few have been found to be superagonists.

So from what I can gather, the person worried that they are drinking too much kratom tea (remember when THAT was supposed to be the detoxification tool?!) may find SR17018 useful, SR17018 is just not potent enough to really be of value to someone using anything much more potent. The affinity value is around that of morphine but even with morphine, a person could in theory consume a gram a day and I'm not confident we know enough about SR17018 to say that a similar dose would safely substitute.

It's not nothing, but it's unrealistic that not a single side-effect is mentioned by anyone ever and I've never heard of a medicine that causes no side-effects whatsoever. It just strikes me that what the vendors are REALLY selling is hope.

 

[Syntherize]

The same problem exists for buprenorphine. It simply isn't potent enough to substitute for fentanyl. It's affinity is lower so one a person's body has adjusted to fentanyl via homeostasis, there are't enough receptors left for it to substitute.

No idea about MGM-15 but the nitazenes are probably even worse because a few have been found to be superagonists.

So from what I can gather, the person worried that they are drinking too much kratom tea (remember when THAT was supposed to be the detoxification tool?!) may find SR17018 useful, SR17018 is just not potent enough to really be of value to someone using anything much more potent. The affinity value is around that of morphine but even with morphine, a person could in theory consume a gram a day and I'm not confident we know enough about SR17018 to say that a similar dose would safely substitute.

It's not nothing, but it's unrealistic that not a single side-effect is mentioned by anyone ever and I've never heard of a medicine that causes no side-effects whatsoever. It just strikes me that what the vendors are REALLY selling is hope.

When I was once coming off a gram per day real heroin habit I tried using my red vein kratom powder (~30g in one dose), and it helped me for like 30min preventing me from shitting my pants lol, but I still had to call my friend to bring me something that afternoon…I still take red vein kratom daily from a reputable source and I’m currently not trying to mess with other potent opioids for the time being because I am happy where I am right now.