Read this whole thing. It's very important.
People are so stupid sometimes. I simple search would have answered you question. God damn I swear sometimes you guys are the most knowledgeable and intelligent people in the world when it comes to harm reduction. Other times like now, I wonder if your mom dropped you on your head.
But just so we're clear Bioavailabilities..
-92% (transdermal)
-50% (buccal)
-33% (ingestion)
Oh and Melting point - 87.5 °C (190 °F)
As you can see it's simply stupid/wasteful to put them in your mouth. They make patches for a reason, that's because it's the best ROA with the best BA. Notice there's not a Oxycodone patch? That's because the oral BA is great, same goes for this with transdermal.
That's because a lot of people on here think they're smarter than the pharmaceutical companies and they found a better way to use the drug but they're wrong. Half of you don't know shit about pharms.
Granted I think they should make hydromorphone and oxymorphone patches because the oral BA is shit, there's probably a reason they don't.
I'd also like to mention for the people recommending cutting the watson patches open and eating the gel, ARE YOU FUCKING KIDDING ME??
Do you have any idea how fucking stupid that is? It is so dangerous on so many levels that YOU don't even understand and I'll try to explain it.
Do you have any idea how many people have died this year alone from doing just that? Fucking Tons.
Shit...
Over 1000 REPORTED Deaths From April 2005 through late March 2007 - Less Than 2 Years.
You do realize that this is a HARM REDUCTION website? That is about the farthest thing from harm reduction there is.
Teaching someone how to shoot heroin properly so they don't do it wrong and dangerously is harm reduction.
Teaching someone how to "get high" by cutting open a patch and then ingesting a drug 81 times more potent than morphine is just irresponsible.
It makes me fucking sick that anyone would suggest that to someone on a harm reduction website. I don't give 2 shits what you think, putting on your gums is ingesting it, you could swallow enough to OD.
Someone that I knew personally and was my friends older brother died at 23 years old because of this exact thing.
He wasn't opiate-naive in anyway and this guy said "yeah just cut it open and eat some of the gel, if you want to get higher put some gel on your gums too."
Well he did and he died. The guy who sold them to him and told him to eat the gel is spending his sweet time in prison, doing 15-25 years.
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You have absolutely no idea what you're messing with when you play around with that shit any other way it's supposed to. It's not just because it's "potent" and "powerful".
Fentanyl is a fully synthetic opioid and acts differently than the other opiates/semi-synthetic opioids.
One reason it's so dangerous is this,
A drug's ability to work properly is directly affected by how much of it binds to the proteins within your blood plasma. The more the drug binds to your proteins (present in plasma) they attach themselves to the drug, the less the drug works but it remains in your body, a lot comes in to play when it comes to protein binding. While it's not affecting your CNS and getting you high, the concentration levels in your plasma/protein keep building and less of the drug becomes "bound". Resulting in a rapid increase in "effectiveness" of the drug. Death.
Another reason fentanyl is such a dangerous drug is the high protein binding can change the drug's half-life. The bound portion of the drug acts like a reservoir from which the drug is slowly released as an unbound form. Now the half life of Fentanyl is "7-17 hours" according to various sources, BUT taking protein plasma binding/plasma/concentration levels etc.. in to account, the half life increases dramatically.
Methadone is similar. (Not in chemilcal structure or high or anything like that).
By that I mean well here I'll put it in the easiest way possible.
Most people that overdose on methadone overdose after the third day, this is due to what I mentioned with Protein Plasma Binding, Concentration Levels Etc..
Reason being that the drug keeps building up in your body. In your cells/plasma etc.. and because of the high binding of proteins the half life (The half life of methadone is extremely long anyway 15 to 60 hours, in rare cases up to
190 hours can increase substantially). This goes for all opiates/opioids, which is why the first dose in the morning is always the best.
The reason it varies so much is Protein binding. Bottom line fentanyl does the same thing, not as greatly as methadone but still very worth mentioning.
To give you an idea of how well fent binds to your proteins..
Fentanyl's Plasma protein binding is 80-85%
Heroin - 0% After It's Converted To Morphine it's 35%
Oxycodone - 45%
Hydromorphone - 20%
Morphine 30–40%
Now all in all this WOULD be a good thing right? I mean the less the drug binds the better it works. Wrong.
It doesn't really matter how well the drug binds when it's one of the most powerful/potent opioids available by RX.
Trust me you wouldn't even want to handle a fentanyl patch if the protein binding was 0%-15%. The lethal dose would be so much lower. It would be somewhere near as potent as Carfentanyl(Carfentanil). At the very least Sufentanil.
Back to my main thought, even suggesting cutting one of those patches open you should get kicked in the nuts 5 times.
Now on to smoking the fent.. Yes it works, and gives you a rush and is a hell of a lot safer than putting a patch in your mouth or god forbid gel.
It's highly ineffective not to mention extremely wasteful
The melting point of Fentanyl is 87.5 °C (190 °F)
Now the average temperature of a flame from a standard lighter(BIC brand) is
Anywhere between... 800° C(1442° F) - 1977° C(3590.6° F)
Now at the lowest heat level (Blue colored flame) it's approx. 800° C, That's a little under ten times the melting point of fent.
But you're using the yellow flame, so that's a little over 18-22 times the melting point of fentanyl, I guarantee that's way past the burning and destroying point.
So it's a humongous waste.
The best way to use fentanyl patches is to do this. I made this up so if anyone reposts it they should give credit where credit's due.
THE AKOMPLICE METHOD
1.) Wash area of skin thoroughly with hot water(don't burn yourself but use as hot as you can because it will open your "pores", towel dry.
2.) Shave the area with a clean sharp razor and NO SHAVING CREAM.
3.) Take a warm washcloth and hold it on the area for 1 minute.
4.) Now dry all the way and apply the patch as directed.
5.) Wait 30 minutes, until it's really stuck on there grab a heat pad, heating pack (you get the picture) Something hot and dry.
6.)Hold it on the area for 5 minutes to increase absorbtion a pretty large amount.
- Be very careful with this, there's also the chance of skin irritation caused by just shaving, to avoid this shave a while before. It will burn a little too.
- I think it's better when you shave right before because your pores are WIDE OPEN, you have actual "cuts" on the area.
-Which will cause accelerated absorption directly into your blood stream, It's pretty close if not better than SC injection.
-Heat is also proven to increase the absorption rate.
I think it says it on the insert.
Anyway, just be safe bro
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
Peace,
-Akomplice
