Fantasy drug combo thread

[Them Witches]

My daily Rx combos, quantity, and dosages would floor most people and they would not even get out of bed to eat. Most would die. If they tried to drive they would crash and end up in jail.

I take like 6qty "B-52's" with over 450mme.

There is only one pharmacy that will take my business in my area. I bring too much heat to a new pharmacy and off-set there quotas too much.

If I had to request anything to add over 24hrs, it would be Oxyfast 20mg/1mL (60mL) oral solution with Diluadid-HP 10mg/1mL IV (8mL), Droperidol 2.5mg/1mL IV (8mL), Versed 40mg IV, and Duraclon IV 40mcg. This would be my ideal 100% out of pain, heavy nodding, no anxiety, and feeling on top of the world.

 

[Them Witches]

Diluadid-HP 10mg/1mL IV (8mL) : 24hrs = 1600MME PO

Oxyfast 20mg/1mL oral solution (60mL) 24hrs = 1800MME PO

Versed IV 40mg = 20mg of Ativan IV : 24hrs

 

[PenguinWithNapalm]

I feel like the best stuff has already been said lol..

But generally I’d go for a imaginary cleaving/ prolonged release Ethylphenidate, paired with a similar formulation of Dextromoramide AND low dose MXE.- this I dub the no reason to ever be miserable again LTD,

If safe in combo I’d combine with some low dose Moxxy/Foxxy (forgotten the chemical names) and GHB, and that would be a comprehensive full spectrum of feel good effects, and a light touch of psychedelia without vibrating fractals at the speed of light repeating again and again.

Why ethylphenidate?

 

[PenguinWithNapalm]

My daily Rx combos, quantity, and dosages would floor most people and they would not even get out of bed to eat. Most would die. If they tried to drive they would crash and end up in jail.

I take like 6qty "B-52's" with over 450mme.

There is only one pharmacy that will take my business in my area. I bring too much heat to a new pharmacy and off-set there quotas too much.

If I had to request anything to add over 24hrs, it would be Oxyfast 20mg/1mL (60mL) oral solution with Diluadid-HP 10mg/1mL IV (8mL), Droperidol 2.5mg/1mL IV (8mL), Versed 40mg IV, and Duraclon IV 40mcg. This would be my ideal 100% out of pain, heavy nodding, no anxiety, and feeling on top of the world.

So 1,200 mg of oxy and 80mg of dilaudid?

 

[KurtAurelius]

Why ethylphenidate?

I’m prescribed Methylphenidate but heard good reports of Ethylphenidate from the RC days when first batches were extremely pure.

I could have picked Cocaine but it’s an inferior compound, due to being a tropane alkaloid it has far worse effects on the heart etc

Likewise there is Dextroamp/DextroMeth, but they are releasers and long half life’s.

Far as I am aware Ethylphenidate is very targeted like Methylphenidate at just DAT and NET, but Ethylphenidate anecdotally being more euphoric.

I could be wrong, I haven’t pulled any evidence out tbf lol

(Edit appears I am wrong with some lazy searches, due to the binding efficiency and preferences, you could swap it out to be any Targeted and Clean DRI/ Inverse Agonist with little NR activity- I’d personally prefer less physical stimulation)

 

[PenguinWithNapalm]

I’m prescribed Methylphenidate but heard good reports of Ethylphenidate from the RC days when first batches were extremely pure.

I could have picked Cocaine but it’s an inferior compound, due to being a tropane alkaloid it has far worse effects on the heart etc

Likewise there is Dextroamp/DextroMeth, but they are releasers and long half life’s.

Far as I am aware Ethylphenidate is very targeted like Methylphenidate at just DAT and NET, but Ethylphenidate anecdotally being more euphoric.

I could be wrong, I haven’t pulled any evidence out tbf lol

(Edit appears I am wrong with some lazy searches, due to the binding efficiency and preferences, you could swap it out to be any Targeted and Clean DRI/ Inverse Agonist with little NR activity- I’d personally prefer less physical stimulation)

Yeah I was gonna say, I looked it up because I was curious and it looks like ethyl has way more nor and slightly less dopamine. I figured maybe you wanted to be extra jolted?

 

[TheLightBringer]

I’m prescribed Methylphenidate but heard good reports of Ethylphenidate from the RC days when first batches were extremely pure.

I could have picked Cocaine but it’s an inferior compound, due to being a tropane alkaloid it has far worse effects on the heart etc

Likewise there is Dextroamp/DextroMeth, but they are releasers and long half life’s.

Far as I am aware Ethylphenidate is very targeted like Methylphenidate at just DAT and NET, but Ethylphenidate anecdotally being more euphoric.

I could be wrong, I haven’t pulled any evidence out tbf lol

(Edit appears I am wrong with some lazy searches, due to the binding efficiency and preferences, you could swap it out to be any Targeted and Clean DRI/ Inverse Agonist with little NR activity- I’d personally prefer less physical stimulation)

I found EPH to be superior to methylphenidate, particularly because I felt it was both smoother, more instantaneous in how fast it kicked in and had a higher dosing ceiling to how far you could push the euphoria. Its also more selective for dopamine.

 

[PenguinWithNapalm]

I found EPH to be superior to methylphenidate, particularly because I felt it was both smoother, more instantaneous in how fast it kicked in and had a higher dosing ceiling to how far you could push the euphoria. Its also more selective for dopamine.

That’s interesting, Wikipedia said that it’s way more active on norepinephrine than MPH and slightly less active on dopamine. I’m curious about trying it now

 

[TheLightBringer]

That’s interesting, Wikipedia said that it’s way more active on norepinephrine than MPH and slightly less active on dopamine. I’m curious about trying it now

Its the opposite actually: ”Ethylphenidate is more selective to the dopamine transporter (DAT) than methylphenidate, having approximately the same efficacy as the parent compound, but has significantly less activity on the norepinephrine transporter”

Its about equally active(slightly more) on DAT as MPH but weaker on NET

Ethylphenidate - Wikipedia

en.wikipedia.org

Makes it a ”smoother” more enjoyable experience

 

[PenguinWithNapalm]

Its the opposite actually: ”Ethylphenidate is more selective to the dopamine transporter (DAT) than methylphenidate, having approximately the same efficacy as the parent compound, but has significantly less activity on the norepinephrine transporter”

Its about equally active(slightly more) on DAT as MPH but weaker on NET

Ethylphenidate - Wikipedia

en.wikipedia.org

Makes it a ”smoother” more enjoyable experience

Ohh interesting! I guess I read it wrong. So the higher the number on the chart the less activity? Admittedly I know really know how to read the chart. I thought that it was the higher the number the more activity

 

[TheLightBringer]

Ohh interesting! I guess I read it wrong. So the higher the number on the chart the less activity? Admittedly I know really know how to read the chart. I thought that it was the higher the number the more activity

Precisely, think of it as the higher the number the more of the substance is required to activate the receptor (when it comes to Kd Values at least)

 

[PenguinWithNapalm]

Precisely, think of it as the higher the number the more of the substance is required to activate the receptor (when it comes to Kd Values at least)

Ohhh okay gotcha! Thank you

 

[TheLightBringer]

For some reason the past 2 weeks a strange idea of a combo has kept popping into my mind.

A low dose VGCC blocker, a low dose benzodiazepine and a long lasting smooth NDRI. Potentially a low dose NMDA antagonist as well

Something like 300mg pregabalin or 1.5 - 2g phenibut, 10mg diazepam, 2 tablets of maximum strength azstarys (totaling 104,6mg Serdexmethylphenidate + 20,8mg instant dexmethylphenidate) and then maybe a low dose of memantine or DXM on top.

Seems like something that would be fun to just pop before heading out and exploring a town in a foreign country. An all day dreamy drunken-ish + NDRI feeling to carry me on an adventure. The low doses of the other inhibitory drugs would smoothen out the D-MPH.

 

[TheLightBringer]

That dosage of azstarys should equate to about 80mg D-MPH though, with the extended release it should leave you flying for 14 hours at that dosage, maybe one would need something to come down

 

[spypilot]

700 mg dramamine, 625 mg dextromethorphan, 60 mg 3FA
this I have done once so I cant exactly call it a fantasy but it was an amazing experience that I fantasize about doing again

 

[placebonaut]

For some reason the past 2 weeks a strange idea of a combo has kept popping into my mind.

A low dose VGCC blocker, a low dose benzodiazepine and a long lasting smooth NDRI. Potentially a low dose NMDA antagonist as well

Something like 300mg pregabalin or 1.5 - 2g phenibut, 10mg diazepam, 2 tablets of maximum strength azstarys (totaling 104,6mg Serdexmethylphenidate + 20,8mg instant dexmethylphenidate) and then maybe a low dose of memantine or DXM on top.

Seems like something that would be fun to just pop before heading out and exploring a town in a foreign country. An all day dreamy drunken-ish + NDRI feeling to carry me on an adventure. The low doses of the other inhibitory drugs would smoothen out the D-MPH.

no experience with azstarys, but i regularly take 300-600 pregab 20mg diazepam with 200-250mg of mephedrone , been up to 280mg but it have my eyes tweaking like high dose MDMA.

have swapped mephedrone with coke quite a bit too, planning on giving it a go with amphetamine instead at some point.

the diazepam helps with the jitters

 

[SigmaDrugCollector]

Personally, I have always wanted to get my hands on some opium. I am a very nostalgic person & have found myself fantasizing about the opium dens of old where one could go to escape the stresses & clamor of the day & curl up in a corner of a dimly lit dive, where included in the price of opium is the assistance of a thin Asian gentleman still sporting the customary Que hair style.
I stumble into an alley to the non descript store front & I knock 3 times , a panel slides open exposing a pair of discerning eyes "password " is heard out loud in broken English, you utter the phrase " red dragon". The door opens as you are escorted to a dimly lit corner with 1 other patron in your sight. The assistant sits next to you Indian Style as he maneuvers the smoking pipe to get it packed & prepared. He is nimble & quick & you can tell he is a seasoned professional at opium pipe intricacies. He readies & lights up a match & takes the first puffs of the undesirable sulfuric smoke , being a good assistant he gets the pipe ready & going as he passes it to you. Immediately you take a volley of 3 deep tokes as you see the clay like substance glow like a beacon in the dark. You focus all your attention on the glow, as you finally exhale you feel a rush of splendid euphoria race all over your eager body, right now, in this very second nothing bothers you , in fact you feel absolutely content knowing the analgesic peak awaits you in the relatively safe opium den where your assistant will look out for you & your belongings should you drift off to explore a different side of consciousness.
Anybody else wish it was 1905 in a San Francisco back alley at the "Red Dragon Inn" where in that small window of time, in these United States for 1 inclusive fee, one could be treated to lodging , an assistant & a dose of opium????

SigmaDrugCollector

 

[TheLightBringer]

700 mg dramamine, 625 mg dextromethorphan, 60 mg 3FA
this I have done once so I cant exactly call it a fantasy but it was an amazing experience that I fantasize about doing again

Goddamn this sounds like an experience. Not sure if positive or negative, could go either way, I could see myself enjoying this when I was in active addiction just for the novelty but that dose of an anticholinergic regularly is toxic af. Feel like id enter another world on that, what was your experience like in regards to hallucinations?

 

[TheLightBringer]

Personally, I have always wanted to get my hands on some opium. I am a very nostalgic person & have found myself fantasizing about the opium dens of old where one could go to escape the stresses & clamor of the day & curl up in a corner of a dimly lit dive, where included in the price of opium is the assistance of a thin Asian gentleman still sporting the customary Que hair style.
I stumble into an alley to the non descript store front & I knock 3 times , a panel slides open exposing a pair of discerning eyes "password " is heard out loud in broken English, you utter the phrase " red dragon". The door opens as you are escorted to a dimly lit corner with 1 other patron in your sight. The assistant sits next to you Indian Style as he maneuvers the smoking pipe to get it packed & prepared. He is nimble & quick & you can tell he is a seasoned professional at opium pipe intricacies. He readies & lights up a match & takes the first puffs of the undesirable sulfuric smoke , being a good assistant he gets the pipe ready & going as he passes it to you. Immediately you take a volley of 3 deep tokes as you see the clay like substance glow like a beacon in the dark. You focus all your attention on the glow, as you finally exhale you feel a rush of splendid euphoria race all over your eager body, right now, in this very second nothing bothers you , in fact you feel absolutely content knowing the analgesic peak awaits you in the relatively safe opium den where your assistant will look out for you & your belongings should you drift off to explore a different side of consciousness.
Anybody else wish it was 1905 in a San Francisco back alley at the "Red Dragon Inn" where in that small window of time, in these United States for 1 inclusive fee, one could be treated to lodging , an assistant & a dose of opium????

SigmaDrugCollector

Not a combo but yes Ive imagined that as well in the past, especially those old pictures and drawings of people just laying in the beds smoking opium and floating away seem quite alluring in its depravity. Though ive had my fair share of drug-den experiences constructed in friends apartments going on fun binges together.

 

[spypilot]

Goddamn this sounds like an experience. Not sure if positive or negative, could go either way, I could see myself enjoying this when I was in active addiction just for the novelty but that dose of an anticholinergic regularly is toxic af. Feel like id enter another world on that, what was your experience like in regards to hallucinations?

i was very functional but also very out of it like i could do shit but sometimes not it was a weird trip
i just saw a bunch of patterns and weird textures on the walls