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Opioids Extracting naloxone from tablets

L

Like dead

Bluelighter
Joined
Jun 24, 2010
Messages
208
I'm just messing with you, this is not about synthesis I just need the mods attention for a particular question. That comes in the end though, keep reading. To ask this question I need to set up an example. So, say we had a couple of tablets containing 50 mg opiate and 4mg naloxone. Let's assume they both degrade at the same rate (the naloxone and the opiate). Would it be possible to crush up and heat this tablet at the temperature and for the amount of time it takes for 4mg naloxone to degrade, whilst leaving 46 mg opiate intact?

If this were so the tablet could be injected (micron filtered and all of course). I know there are a few flaws. One being that the opiate may evaporate. Though at low temp for a long enough time I think most could be preserved (from evaporation). Also, remember this is under perfect conditions. Please tell me I this is possible or if you detect any flaws and how YOU think this could be done practically.If any part of the question was hard to understand please say so, I will re-explain.
 
Last edited by a moderator:
Naloxone is just as heat-stable as all the other opiates (which are far too heavy to evaporate under most circumstances) and would produce all sorts of nasty stuff if it did go through thermal breakdown. I don't think this would work.
 
My main question is, will the opiate degrade proportionally or will it degrade in the same quantity? Il figure the rest out when I know that.
 
If it's Talwin there is a shitload of talc in it.


Just guessing from the mg's.

Check the Merck manual and see what the melting point of each is. Then you will have at least part of your answer
 
heating the pill basically defeats the purpose of filtering it. depending on what binders and fillers are included in the water they may become soluble when the solution is heated and filtered. it's best not to add heat to pills for injection.

Now to my question for the mods, am I allowed to make a thread about the likelyhood of recieving "under the counter drugs" in Australia? Here are some pro arguments if you can't come to a conclusion: it's NOT synthesis discussion, it's NOT about how or where to obtain drugs and it's for the good of another human being.
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no you're not and that justification is laughable at best. use google and check out the aussie forums about our drug culture, but you can't go starting any threads on how to score from our chemists. it would be worth checking out our drug laws if you're intending on coming.

you've got a better shot at being a rock star than finding a crooked pharmacist (or assistant) here.
 
^oh how do you know i'm not a she?

can you think of something serious you'd like your thread renamed too as well, please. the current one isn't doing your thread any favours
 
leftwing said:
^oh how do you know i'm not a she?

can you think of something serious you'd like your thread renamed too as well, please. the current one isn't doing your thread any favours
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seems like it got the attention of the mods : ) I'll change it
 
^He's not REALLY a mod, we just give him the title and let him play around a little. Now change that title or I'll infract you right in the testicles.
 
ha, you silly fools, only mods can edit title changes. so just give us a sensible title and we'll hook you up.

*gets back on broomstick and makes fucking motion*
 
DAMNIT lefty, why do you have to spoil my fun. I had my infracter aimed right between the jewlz.
 
leftwing said:
heating the pill basically defeats the purpose of filtering it. depending on what binders and fillers are included in the water they may become soluble when the solution is heated and filtered. it's best not to add heat to pills for injection.



no you're not and that justification is laughable at best. use google and check out the aussie forums about our drug culture, but you can't go starting any threads on how to score from our chemists. it would be worth checking out our drug laws if you're intending on coming.

you've got a better shot at being a rock star than finding a crooked pharmacist (or assistant) here.
Click to expand...

First of all, I'm already here. Creepy isn't it? About the heating pills, it has nothing to do with the filtering. I too have had to survive the various threads in which people get ass raped for heating their pills before filtering. I'm well aware of the fact that your not supposed to do that. I'm asking if you can heat the pills (crushed up or in solution AFTER filtering) to destroy all or most of the naloxone and leaving most of the opiate intact. This is so that the naloxone doesn't do it's antagonist thing and ruin the experience.

Change it to my first post title please. Ps u guys aren't nice : )
 
Like dead said:
First of all, I'm already here. Creepy isn't it? About the heating pills, it has nothing to do with the filtering. I too have had to survive the various threads in which people get ass raped for heating their pills before filtering. I'm well aware of the fact that your not supposed to do that. I'm asking if you can heat the pills (crushed up or in solution AFTER filtering) to destroy all or most of the naloxone and leaving most of the opiate intact. This is so that the naloxone doesn't do it's antagonist thing and ruin the experience.

Change it to my first post title please. Ps u guys aren't nice : )
Click to expand...

it's not creepy until you're in my dreams.

thanks for clarifying that too.

what opiate are you using? if it's binding affinity on the mu is stronger than that of the nalaxone, having a longer half-life (ie - suboxone) then it's not going to affect it.
 
Well, it does something, even in combination with buprenorphine. However although this thread applies to all pills containing a substantialy larger amount of opiate than naloxone, the specific opiate which I'm going to try this out on (after gathering info) is tilidin. A rarely encountered opiate (in Australia) which is used mainly in Europe. The formulation is 50 mg tilidin to 4mg naloxone.

I don't know much about tilidin at all because it's very hard to find info on it (even in German). My theory is that if you have a solution containing 4 mg naloxone and 50 mg tilidin, and they both degrade at the rate of 1mg per minute at 80 degrees celcius, one could heat the solution at 80 degrees for 4 minutes and have 46 mg tilidin, no naloxone and the products of degredation.

All the info I need is: at what rate does tilidin degrade and at what temperature, the same for naloxone, the products of degredation (to make sure nothing toxic is formed) and boiling point of naloxone and tilidin. Another method may be to evaporate off the naloxone, but that's only possible if naloxone has a far lower BP than tilidin. Btw I'm talking about the HCL salts. I think tilidin has a lower affinity to opiate receptors. It's a weak drug, but in Germany it's well known for it's rush so I want to try it. I have two 50/4 mg tablets so I only have one shot at this (lol, shot).
 
^the consensus here and in the literature seems to be that even in IV doses, the suboxone formulation doesn't produce effects via the naloxone because the buprenorphine's affinity outcompete's the naloxone's. A high enough dose of naloxone could override the buprenorphine but in the ratio's present in the pharmaceutical preparations, the naloxone is effectively inactive.

Would you prefer this be moved to Advanced Drug Discussion? You may get better responses.
 
do you mean austria and not australia, cause i'm australian and heard of no tilidin; i'm on pain managment and have gone through pretty much through every opiate available by script here never to hear that combination uttered anywhere.

the ratio of opiate/nalaxone is only going to be relevant when the nalaxone out competes the opiate' in question binding affinity and half life
 
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