Sure euphoria is possible but a VERY small percentage of people report any positive experiences on "recreational" doses of anticholinergics... these include datura, belladonna, jimson weed and common pharmaceuticals such as diphenhydramine (benadryl/tylenol PM) or dimenhydrinate (dramamine) among many others.
I, and i know most would echo this sentiment, would STRONGLY advise against trying to use datura recreationally. It makes most people feel like shit and in high doses makes people delirious and have terrifying hallucinations indistinguishable from reality such as snakes and spiders attacking you.
conclusion: euphoria is possible but exceedingly unlikely. Also, don't be a dick to people who respond to you. BL is all about the PLUR