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Phenethylamines Ergolines and phenethylamines receptor orientation

In passing, they found a way to directly sub to 13 or 14 position directly. Apparently it affects dopamine binding differently and results in adjustment to the come down phase of an LSD trip.
More than twenty years ago he wanted to test it, called in a bunch of favors to make it from scratch, got what he needed, but the synth was a fraud he relied on. So now they have a way. Should be published in a year or two.
 
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Sansert said:
Apparently it affects dopamine binding differently
Click to expand...

This was initially seen with the metabolite 13-hydroxylergotrile which is 100-fold more potent as a dopamine agonist than lergotrile itself.

13' ergoline corresponds to 7' aminotetralin and 7-OH-DPAT is a potent D3 agonist.
 
Allylbenzene said:
This was initially seen with the metabolite 13-hydroxylergotrile which is 100-fold more potent as a dopamine agonist than lergotrile itself.

13' ergoline corresponds to 7' aminotetralin and 7-OH-DPAT is a potent D3 agonist.
Click to expand...
They finally initially made the ho from scratch and discovered, 380 fold more potent with LSD, so they put several small carbon attachments there and found several that now block its formation in the body. Then the direct sub discovery
 

US20230365552A1 - Lysergic acid derivatives and methods - Google Patents

Methods of preparation of lysergic acid and derivatives thereof. Methods of using lysergic acid and derivatives thereof, such as methods of treating neurodegenerative disorders. Derivatives of lysergic acid and pharmaceutically acceptable salts thereof.
patents.google.com

Inoue et al. (Synthetic studies toward (+)-lysergic acid: construction of the tetracyclic ergoline skeleton, heterocycles, 79, 373 - 378, pub’d 1/16/2009). (Year: 2009) *
Liu et al. (Total Synthesis of (+)-Lysergic Acid, J. Org. Chem. 2013, 78, 21, 10885–10893, pub’d 10/10/2013) (Year: 2013) *
Liu et al. (Total Synthesis of (+)-Lysergic Acid, Org Lett., 13(18), 4810-3, pub’d 08/25/2011) (Year: 2011)

* Cited by examiner, † Cited by third party
 
4DQSAR said:

US20230365552A1 - Lysergic acid derivatives and methods - Google Patents

Methods of preparation of lysergic acid and derivatives thereof. Methods of using lysergic acid and derivatives thereof, such as methods of treating neurodegenerative disorders. Derivatives of lysergic acid and pharmaceutically acceptable salts thereof.
patents.google.com

Inoue et al. (Synthetic studies toward (+)-lysergic acid: construction of the tetracyclic ergoline skeleton, heterocycles, 79, 373 - 378, pub’d 1/16/2009). (Year: 2009) *
Liu et al. (Total Synthesis of (+)-Lysergic Acid, J. Org. Chem. 2013, 78, 21, 10885–10893, pub’d 10/10/2013) (Year: 2013) *
Liu et al. (Total Synthesis of (+)-Lysergic Acid, Org Lett., 13(18), 4810-3, pub’d 08/25/2011) (Year: 2011)
Click to expand...
I posted the joel smith patent in here previously it was removed as it has the t3p
Synthesis route
 
Sansert said:
Look how pathetically weak you are.
I have interacted with nichols for years
Regularly
That guaranteed fact
Or your hot air without evidence.
Know anything about meta data, ms heard?
Click to expand...
I put it on a page
go copy it and get the info
iwin4godandherandforgood.wordpress.com

Pic

R
iwin4godandherandforgood.wordpress.com iwin4godandherandforgood.wordpress.com
 
4DQSAR said:

US20230365552A1 - Lysergic acid derivatives and methods - Google Patents

Methods of preparation of lysergic acid and derivatives thereof. Methods of using lysergic acid and derivatives thereof, such as methods of treating neurodegenerative disorders. Derivatives of lysergic acid and pharmaceutically acceptable salts thereof.
patents.google.com


* Cited by examiner, † Cited by third party
Click to expand...
Good thing when you post the patent here, it wont be removed for some reason. Is that where you got it from at first?
 
Sansert said:
They finally initially made the ho from scratch and discovered, 380 fold more potent with LSD, so they put several small carbon attachments there and found several that now block its formation in the body. Then the direct sub discovery
Click to expand...

According to the literature it was in 1978 that was documented lergotrile → 13-OH-lergotrile and it's increased potency. The notable potency of 13-OH-LSD was confirmed in 2026.
 
4DQSAR said:
[IGNORE]
Click to expand...
Now why dont i believe you?
That would your break streak of trying to convince or dupe others into thinking reality is different than it is. I wish you would. Want to help make an old bday wish come true?
 
Sansert said:
they found a way to directly sub to 13 or 14 position directly.
Click to expand...

Also 12-OH-LSD, but no details about which receptors it targets:
In drug discrimination tests, 12-OH-LSD completely substituted for LSD, but was only about half as potent. However, this derivative would also be more polar than LSD and pharmacokinetic factors could play a role in its decreased activity.

Nichols DE, Oberlender R, McKenna DJ (1991). "Stereochemical Aspects of Hallucinogenesis".
Click to expand...
 
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