• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Entactogens/Entheogens of the Future.

I know the 4-methoxy is pretty dangerous, it causes hypertensive crisis. I hope the 3-methoxy doesn't share these traits. Which isomer is more active? Anything known about the 4-chain analogue.
 
d-isomer more active, d/l racemate probably preferable
not as dangerous as 4-MeO-MA
but keep doses low to start (less than 50mg)
and to be safe do not combine with meth until MAOI activity or lack thereof is established
should be great

it's a (distant but still legitimate) analogue of bupropion
 
strong Stimulant
strong Entheogen
touch of Hallucinogen

the Stimulant aspect is balanced by the Entheogenic aspect
 
It seems from Nichol's paper about Entactogens based on MDA structure that for the entactogen activity (ie serotonin efflux) that the meta position w.r.t. the side chain (the 3 position or 5 depending on where the numbering starts) requires an atom containing a lone pair for said activity. With MDA the oxygen is constrained by the methylenedioxy ring system, wheras a 3-methoxy group has no such restraint making the 3-methoxy group less potent than the ring bound oxygen.

The only problem I could possibly forsee with 3-methoxymethamphetamine is does it have enough dopaminergic activity? After all, 3-methoxy-4-methylamphetamine is a potent serotonogic agent, but because of a lack of dopaminergic activity isn't really too hot as an entactogen
 
3-MeO-MA has more dopaminergic activity than MDMA.
Maybe because it has a 4-H like meth--just a theory there.
It is certainly in my opinion more desirable than 3-MeO-4-Me-A.
Also the more oxidized the benzene ring becomes, the "weaker" it gets.
After all, it's a form of combustion.
The 3-MeO functional group has 2 lone pairs of electrons and is much sturdier with respect to metabolism than a 3,4-MDO group.
 
Another good one is 3-Cl-methamphetamine.
It's a lot more toxic than 3-MeO-MA but you'll get amazing CEVs.
3-MeO-MA makes colors incredibly beautiful.

And I've heard (but never tried) that 3-I-4-MeO-A is extremely hallucinogenic.
 
Last edited:
Yes, but it's not as good.

I can't remember but it goes something like this:
R-NO2 + Fe/Zn + HCl --> R=O
 
That IS interesting since, apart from MDMA, the secondary amines are less potent with the substituted amphetamines. So it does act like MDMA?
 
Yes, a better title for this thread would be "3, 4, and 3,4-(di)substituted methamphetamines I have thought invented and loved."

You *won't* be disappointed.
 
It's only lethal if you overdose, but since I'm immortal and furthermore the time I did it best was telepathically (the other time in real life was like 25mg pressed pills and I took 3 or 4 and that wasn't as good as the first time).

If you don't think you are immortal already or do not want to become immortal, you have no business delving into the multiverse of pyschedelica. Sorry. YMMV.

Furthermore, I don't think it would even kill a mortal at the 100-125mg level, but again, I don't give a shit if it kills you or not. You are expendable.

Have a nice day. :)
 
The only two I recommend thus far are:

3-Cl-methamphetamine HCl.
and
3-MeO-methamphetamine HCl.

I tried 3-EtO-methamphetamine, but it was too sedating.
 
The 'acid test' (oh how I liked punning that one!) for entactogens as opposed to straight psychedelics ios if the S isomer is more potent, it's mainly entactogenic in action (well that only applies to optically active phenethylamine derivatives - psychedelic phenethylamines are more active as the R isomer)

And MDA has different pharmacological profiles for the S isomer & the R isomer, the raceamate possessing both psychedelic & entactogenic activity
 
I don't F-ing know, all I know is the racemate F-ing rocks, m'kay.

"Ain't no need to questiong the authorities."--A Tribe Called Quest.

And yes, I am an arse hole when on alcohol or heroin.


I've mentioned about where this leads, if you feel angst ridden, don't post before it becomes that you can't post
 
Last edited by a moderator:
Dual substituted analogues of existing 4- and 5- substituted tryptamine RCs would be very interesting.
 
shulgin in the nature article written with naranjo in nature 1969 stated that 3meoamphetamine was active at >1 MU... so guess over 300mg.
shulgin also reports no central effects at 50mg (2x 2mg) for 3-MA in a later paper

I am intrigued that the N-methyl derivative is so much more potent.
 
You must log in or register to reply here.
Top