• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Entactogens/Entheogens of the Future.

fastandbulbous said:
Personally I don't see why they don't try 7-methoxy-5-(2-aminopropyl)indan. It;s to MMDA what IAP is to MDA. It may have some qualities in common with MMDA. Well worth finding out eh?
Click to expand...

That would definately be interesting, yeah. Persaonally IAP was found to be very nice.
 
3,4 methylenedioxy aminorex might prove to be interesting. Benzaldehyde->aminorex in 5 stages (a tad too much synthesis details for the forum)
 
Last edited by a moderator:
4-MAR and METH feel so similar as to be hard to distinguish from one another without being told which is which first. I would expect the same relationship between MDMA and MD-4-MAR, but who cares.
 
Helios. said:
4-MAR and METH feel so similar as to be hard to distinguish from one another without being told which is which first. I would expect the same relationship between MDMA and MD-4-MAR, but who cares.
Click to expand...

I found them WAY different but everyone is different. I would have though aminorex and meth would be similar, but not 4MAR. p-F aminorex looks good right now...
 
Does anyone know if the 1,3-Dihydro-isobenzofuran analogue of MDMA has been researched? (or whether it is stable enough to do so?)

As I understood it the oxygen was found to be important in only one of the benzofuran analogues (the one where the oxygen is at the 4 position, is that right?)

Anyway would the 1,3-Dihydro-isobenzofuran analogue be a kind of half way maybe??
 

Attachments

  • OXYGEN.gif
    OXYGEN.gif
    1.4 KB · Views: 57
Has anyone ever tried MMAI yet? Is it a dud, too serotonergic with not enough dopaminergic actions?
 
slopoke said:
Has anyone ever tried MMAI yet? Is it a dud, too serotonergic with not enough dopaminergic actions?
Click to expand...

Has bog all dopaminergic activity, but that can ve overcome by co-admin of a dopaminergic agent (but neurotoxicity increases due to 5HT neurones taking up the dopamine released and getting paggered by it's oxidation to recative 0rtho-quinone derivatives)


As I understood it the oxygen was found to be important in only one of the benzofuran analogues (the one where the oxygen is at the 4 position, is that right?)
Click to expand...

No, the oxygen is important in the 3 position, but for good entactogenic activity (5HT and dopamine activity) needs to be constrained within the 5 membered ring. The 4-oxygen position compound has very little dopaminergic activity (less than IAP) whereas the 3-position derivative has a lot more dopaminergic activity than IAP and not a great deal less than MDA
 
Whats your opinion on the Isobenzofuran analogue? (pictured above)

With the oxygen in the middle and two carbons connecting to the 3 and 4 position on the PEA skeleton.
 
except it probably causes lots of oxidative damage from being an ether at the primary attack site.
 
Really it depends upon dopamine being oxidized to the ortho quinone to cause the majority of damage associated with MDA/MDMA, so any damage due to it would mostly depend upon it's pharmacology rather than it's metabolism toxicology
 
Replacing the methylenedioxy with a dihydrofuran ring looks a very interesting proposition indeed. I shouldn't think the requisite benzaldehyde would raise too many eyebrows either...
 
4-mar, 4fmp, all the other analogs u guys speak of.. these chemicals SOUND AMAZING. like the perfect drug. drugs id kill to have. if these drugs are as great as they sound tho why arent they being mass produced and sold on every street corner?
 
^They aren't too great by themselves.

IAP is pretty crap when taken in isolation. But I have a feeling it'd be EXCELLENT when taken with something like MDPV!

They won't catch on for quite some time yet for this reason - they're too complicated. People want a single compound they can dose and feel good with.
 
4-mar, 4fmp, and alot of the other chemicals mentioned in this thread and others sound to be just fine by themselves.

what is IAP and MDPV?
 
All of these 3-substituted amphetamines would make me a little nervous. Monosubstituted amphetamines do not exactly have a great history or safety profile:

para-chloro-A: highly neurotoxic, cardiotoxic
fenfluramine: neurotoxic, highly cardiotoxic
4-MeO-A: highly cardiotoxic (great way to trigger a heart attack), MAOI
4-MeS-A: same as above
4-Me-A and 4-Me-MA: neurotoxic

I would think that 3-chloro-A or -MA would also be quite dangerous, especially for the heart (due to serotonergic activity). The only mono-halogenated amphetamine that I have heard nothing but good things about (and would love to experience some day) is 4-fluoro-amphetamine (4-FA). As the fluorine moiety is sterically similar to a hydrogen, but very electron withdrawing, it would seem that one gets the best of both worlds.

Of course, once we start introducing more than one phenyl substituent, then we start to venture into the realm of psychedelia and the safety profile increases dramatically.
 
Last edited:
I must say - instictively I never liked the idea of 4-Fluoro-Amphetamine and as such never tried it. (Not that I wouldn't ever try it)

It's silly really as there are a lot more chemicals which would be considered more risky (simply because even less is known about them).

But, as has already been mentioned above ^ I think its just because so many 4-substited-PEA (with no other substitutions) have resulted in major problems. It also seemed chemicals like 4-FA had nothing *particularly* unique to offer from reading about them.
 
You must log in or register to reply here.
Top