If you are unaware btw.
About beta-C=O homolog of 2C-B, it is INCREDIBLY unstable. Do NOT add it to H2O, oral maybe. Managed to inject it ONCE before it dimerized to inactive purple shitbox. But in solution its unstable as fuck, particularly as the freebase.
Have tried plugging it only for it to turn to inactive purple pyrazine shite before my very peepers before it got halfway from measuring cup to arsehole. Literally. Primary amine beta-ketones are the most unstable sons of bitches. They are...think the psychotropic drug version of nitrogen trichloride. Only less likely to blast your head off physically in a cloud of shrapnel (NCl3 did this to it's discoverer, and IIRC to I think, either Lussac, Lavoisier or Davy. One of them, forget which, had to hire Faraday as an assistant after a nitrogen trichloride explosion tore the poor bastard's eye up and blinded him for a while.
But beta-C=O-2C-B whilst no psychotically unstable explosive, lacks only the 'explosive' portion of that description.
Also, it appears to be somewhat of a vasoconstrictor, it made me feel very, very cold and shivery even after snuggling up under the quilt in bed after taking some once, presumably this is because the ketone group likely as not will be metabolized to the corresponding alcohol, which is to BK-2C-B what norephedrine is to cathinone, chemically speaking. And we all know what khat is like, it must be fresh as can be to have optimum effect when chewing khat, because cathinone (methcathinone being a '2 amine is not subject to this dimerization and pyrazine formation like the primary amine versions are.)
I personally cannot for the buggerment of me understand why the hellfire and unicycle-mounted otter based sodomy that when BK-2C-B was released, it was not marketed as the corresponding pthalimidopropiophenone, which would then cleave in the stomach acid to release the BK-2C-B slowly enough and steadily to provide both, one would think, a smoother comeup and releasing it bit by bit, kind of an XR version, avoid high concentrations and ergo, allowing for less of a chance for one molecule of the 'cat to meet up with another and dimerize to shite due to lower concentrations within the environment of the stomach.
Slow and steady winning the race, being the idea.
Also, to OrdinaryMind-be aware, that fent and its analogs bind to MORs in a different configuration than do most opioids, and either this, the very high potency (although the lower potency end fent alfentanil, whilst rather tasty stuff as a once in a while treat, as far as fents go, ain't bad, it still does cause increased tolerance very quickly, despite much lesser potency than many fentanyl derivatives)
So presumably the alternate binding mode may perhaps, be conducive to the extremely rapid tachyphylaxis, and also, with fents, they don't just downregulate MORs with use, fentanyl and co also result in very rapid internalization of Mu opioid receptors, requiring new ones to be exocytosed to the cell membrane surface within the synapse before the wee buggers are good to go again.
Fentanyl and the whole family aren't too great, only ones I've appreciated much have been alfentanil and lofentanil. Tolerance is a BASTARD with these drugs. Tachyphylaxis. High potency makes for rapid receptor downregulation, and also, again, there is much MUCH more rapid, pronounced receptor internalization with fents than most opioids and opiates.
They will all jack up your opiate tolerance incredibly rapidly. I myself once was test-scripted fentanyl patches, plain vanilla fent, and as I just didn't like it much, ended up doing the entire lot in a single day, and even after shooting just one patch (note, do NOT take this as a suggestion to DO that, I myself had at the time even then a beastly tolerance to opiates. But I was back at the surgery the next day begging for another oxycontin 80 rx instead. Thankfully I got one, and without the doc asking for the patches back. Which is just as well since I'd shot the lot since. Only good thing to come out of that, was having picked up a couple of weeks worth of OC80s on one day, being given the fent the next (week worth of patches) and then since I said I wanted back on the OCs and off the fent right then and there the next day I ended up getting not only the box of fent patches, but two fortnight's worth of OC80s (two a day at the time) in two days, that ended up being allowed my only having them last a week, because the fent, that ONE day's use, albeit quite a bit of the stuff, IV, not that the doc knew THAT part, pushed up my tolerance so far so fast that day before, I could bang two OC80s, IV, filtered of course, and nod out, albeit sod all rush, as there is little to none with oxy. And nod heavily at that. Two being able to slam 5-6 of them in an hour and then start nodding.
On, and Happy Christmas
