Well the 3-ring (pam) has significant alpha 1 affinity. Do you like alcohol as these will trigger the receptors associated with alcohol intoxication.
The -lam is 4-ring (usually a triazolo) and they contain a 2-methyl that doubles activity BUT provides the body with a convenient way to metabolise the stuff.
Of course ALL of these are based on the 1,4-benzodiazepine scaffold. I've found and posted some very potent compounds based on the 1,5-benzodiazepine scaffold which binds as totally different sites. It doesn't matter if you have tolerance and dependence to 1,4-benzodiazepines, these will work like you NEVER took a benzo before.