I think Danthemanz is a little Spartan…… Here is what I found to be true from the people I have talked to. You are not them, so your mileage may vary.
Weed + SSRI….not too much of a problem, although if you are taking the SSRI for anxiety, THC may increase this and thus negate your SSRI.
MDMA + SSRI…..waste of money unless you take a lot , which you shouldn’t when you are taking and SSRI
Shrooms/cid+ SSRI….. A reduced effect, this can be compensated for by taking more LSD/psilocibin. I have not noticed any strange negative interaction, nor has anyone else I know other than the loss of potency of the trip. It took roughly 2x as much hallucionogen to get the same effect as taken at baseline.
SSRI+Speed…… hmmm, haven’t tried it. I imagine they would work ok together, if taken moderately. I am sure others will have more on this…….. The up/down swing of speed makes treating depression or anxiety a real bitch.
SSRI+coke… no problems reported.
SSRI-K……nothing strange noted
SSRI Ethanol……. Worse hangover /headache
SSRI+DXM…… dangerous and nasty for most, some like it more than without the SSRI.
SSRI+Benzo….. just fine. But see below.
Benzos work on a different set of receptors called GABA receptors. To put it in simple terms, they make GABA work better. GABA is used by your brain to slow down (inhibitory) signal, thus drugs like benzo’s booze and GHB all are sedative. This is a bummer if you have chronic depression and you take Benzo’s as they can increase the chance of more severe depressive symptoms. They are prescribed for anxiety. They also have a terrible terrible withdraw if taken in excess for too long.