Drug designs. (MedicinalUser SAR thread)

[Rectify]

Are you saying

BOUNCE
1-phenyl-1-carbomethoxy-2-methylaminopropane

doesn't work?

Tryptamine and ergoline analogues are not not really my thing.

Maybe next time I get something speedy, I'll try to post your molecules, but some of them seem super hard to name with IUPAC to the point that I'm not sure what you mean.

Try giving the names to me one at a time?

Also, many of them are not correctly named. For example, you can't just say "phenyl etc. etc. 2,3-furan etc. etc. amine" because the 2,3-furan won't come up right in the drawing.

 

[MedicinalUser247]

It "may" not work because it dosn't relate to any known substance. To me it looks like it might just be a mild stimulant.

 

[Rectify]

It's Ritalin (Methylphenidate) minus a
R-CH2CH2-R' in the cyclic piperidine ring.

You should try it.

 

[MedicinalUser247]

LOL. Like I said I don't have a lab.

 

[MedicinalUser247]

https://www.researchgate.net/figure/Structure-of-ergoline_fig23_210205887 Anyway, The numbers for the ergoline structure are posted on the net. With it you can design all sorts LSD like structures.

 

[MedicinalUser247]

https://en.wikipedia.org/wiki/Lysergic_acid_2,4-dimethylazetidide#/media/File:LSD-azetidine.svg And make analogs of LSD.

 

[Rectify]

I tried that azetidine-LSD stuff. Took one hit, didn't trip.

 

[MedicinalUser247]

Hmmm... That's odd.

 

[MedicinalUser247]

Now as for potent tryptamines. The most potent one I designed is 4,5-Dimethoxytryptamine.

 

[Rectify]

What happened to the dimethylamine?

 

[MedicinalUser247]

Dimethylamine ?

 

[Rectify]

Okay, well here it is

4,5-dimethoxy-tryptamine

Didn't you want a DMT derivative? (3°N)
That right there is just a tryptamine.(1°N)

 

[MedicinalUser247]

Oh.. Yeah. It's just that I found out that if it were a 4,5-Dimethoxytryptamine that it would be a full agonist. 4,5-Dimethoxy-N-dimethyltryptamine is only partial agonist.

 

[MedicinalUser247]

And for anyone reading this I'm talking about 5ht-2.

 

[Rectify]

That's a new one.

 

[Rectify]

What do you think of this then?

1-(4,5-methylenedioxyindole-3-yl)-2-aminoethane

 

[MedicinalUser247]

Another one that's interesting is 4,5-Methylene dioxy AMT.

 

[Rectify]

1-(4-hydroxy-5-methoxyindole-3-yl)-2-aminoethane

1-(4,5-methylenedioxyindole-3-yl)-2-aminopropane

 

[MedicinalUser247]

You know what would be interesting to see is a Methylene dioxy attached to RDS-127.

 

[Rectify]

N,N-dipropyl-2-amino-4,7-dimethoxy-5,6-methylenedioxyindan