Drug designs. (MedicinalUser SAR thread)

[Smyth2]

I call this one ZMA. https://ibb.co/1KmNyfS It's less toxic.

Seems like a wikipedia page was recently created for this design: https://en.wikipedia.org/wiki/ODMA_(drug)

Come to think of it this is not the first time I have seen this substitution arrangement.

Think: Furazabol
See also: Farampator & Darodipine.

 

[MedicinalUser247]

Here's another design of NON-MA-K that I designed to be less toxic, but It won't get you as high. https://ibb.co/NSBgwQf

 

[MedicinalUser247]

I call this one MD-B-OH-PEA. https://ibb.co/9gK0Pb8

 

[MedicinalUser247]

I call this one 2C-MD-K. https://ibb.co/sFqMyD6

 

[MedicinalUser247]

I call this one Lady-Dust. https://ibb.co/pf1v9cN

 

[MedicinalUser247]

I call this one MDMA-Extra. https://ibb.co/rkB3Ctk

 

[MedicinalUser247]

I call this one Special-M. https://ibb.co/jDz3zBd

 

[Smyth2]

This agent is in the database but idk what it links to:

PCamp hosted at ImgBB

Image PCamp hosted in ImgBB

ibb.co

1-phenyl-N-(1-phenylpropan-2-yl)cyclohexan-1-amine

1-phenyl-N-(1-phenylpropan-2-yl)cyclohexan-1-amine | C21H27N | CID 117067197 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

 

[MedicinalUser247]

I call this one MD-Sero. https://ibb.co/BTbFNvx

 

[MedicinalUser247]

I call this one MD-Sero-2.0 https://ibb.co/PmjCjr3

 

[MedicinalUser247]

I call this one Amphetocaine. https://ibb.co/v3jzyVp

 

[Smyth2]

Just the amide of Tropacocaine works and is here in the database:

N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]benzamide

N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]benzamide | C15H20N2O | CID 11265061 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

 

[MedicinalUser247]

Yes, but I was trying to design something stronger.

 

[MedicinalUser247]

I call this one MDMo. https://ibb.co/3v2RP93

 

[Smyth2]

Yes, but I was trying to design something stronger.

Here let me show you this one:

3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ene
PC10221020
Monoaminergic reuptake inhibitor S>N>D ordered TRI.

nM = 79 DA, 26 NE, 4.7 SER
​

Peter Moldt, Jørgen SCHEEL-KRÜGER, Gunnar M. Olsen, Elsebet Østergaard NIELSEN , WO1997013770 (1997 to Neurosearch A/S).

The N-demethylated compound is called HK3-263.

DAT 16nM, SERT 0.3nM, NET 20nM

Kaur H, Izenwasser S, Verma A, Wade D, Housman A, Stevens ED, Mobley DL, Trudell ML. Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. doi: 10.1016/j.bmcl.2009.10.087. Epub 2009 Oct 23. PMID: 19896846; PMCID: PMC2788963.

I suggest reading this patent as well: Dan Peters, Bjarne H. Dahl, John Paul Redrobe, Elsebet Østergaard NIELSEN, WO2007025978 (2007 to Neurosearch A/S).

 

[MedicinalUser247]

I call this one Chloronaught. https://ibb.co/7Qhs7Zs

 

[MedicinalUser247]

I call this one Chloronaught. https://ibb.co/7Qhs7Zs

The only problem with this design is I don't know if it would be Biologically active.

 

[MedicinalUser247]

I call this one MD-Chill. https://ibb.co/sm5RDZ6

 

[MedicinalUser247]

I call this one Chloro-Electric. https://ibb.co/4W1pJHJ

 

[MedicinalUser247]

I call this one CMDMo. https://ibb.co/mHKmNmP