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Drug designs. (MedicinalUser SAR thread)

MedicinalUser247 said:
I call this one Chloro-Electric. https://ibb.co/4W1pJHJ
Click to expand...
Have you considered 2-Amino-6,7-dichlorotetralin?
pubchem.ncbi.nlm.nih.gov

6,7-Dichloro-1,2,3,4-tetrahydronaphthalen-2-amine

6,7-Dichloro-1,2,3,4-tetrahydronaphthalen-2-amine | C10H11Cl2N | CID 19699404 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
Bryan B Molloy, US3919316 (1975 to Eli Lilly and Co).

It's patented by the inventor of Prozac.
 
Smyth2 said:
Have you considered 2-Amino-6,7-dichlorotetralin?
pubchem.ncbi.nlm.nih.gov

6,7-Dichloro-1,2,3,4-tetrahydronaphthalen-2-amine

6,7-Dichloro-1,2,3,4-tetrahydronaphthalen-2-amine | C10H11Cl2N | CID 19699404 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
Bryan B Molloy, US3919316 (1975 to Eli Lilly and Co).

It's patented by the inventor of Prozac.
Click to expand...
Yes, that's why I made it stronger.
 
MedicinalUser247 said:
I call this one MDMA-C. https://ibb.co/n3RsRdm
Click to expand...
No way I'd ever consider ingesting this one. Aliphatic chloro substitutions are no bueno from a toxicology standpoint.

MedicinalUser247 said:
I call this one MD-PCE. https://ibb.co/ZWjXhw1
Click to expand...
MedicinalUser247 said:
I call this one MD-O-PCM. https://ibb.co/MpfXX3r
Click to expand...
These already exist. I actually have/had some 3,4-MD-PCP, 3,4-MD-PCiPr and 3,4-MD-PCPr and know of others who've sampled the ones you mentioned.
 
Ha, there's plenty! Coming up with potentially interesting compounds is not that difficult if you're following the current research and if you've tried a good variety of related compounds. Coming up with an economically viable synthesis method which then actually works is another thing though.

In terms of ACH's I wanna see some more PCsBu analogs like 3-Cl-PCsBu (I love 3-Cl-PCP) or 3-Me-PCsBu (3-Me for full on hedonism) because 3-MeO-PCsBu was a unique experience and highly selective for mania without really inducing physical dissociation (you can read about it here). Putting a carbonyl on the 2-position of the cyclohexane ring could also be interesting and then resolving the different stereoisomers. Then shifting the carbon of the sec-butyl to an iso-butyl on the amine also sounds like it could be worth exploring.

In terms of PEA's I'd love to see 2C-SF5 (4-pentafluorosulfanyl) being made but the synthesis would be extremely expensive and not really worth it. The SF5-group has very strong electron-withdrawing effects (stronger than CF3) and the high polarity/lipophilicity in the 4-position could make for a very potent 2C compound. Steric bulk might make it a bit less potent than one would expect but the size should definitely be tolerated for decent activity. Then DO*, NBOH, NBOMe, NBI, and the other analog shenanigans.

Would love to see some tetrahydroisoquinoline analogs of the common 2C compounds (not that I think they would be particularily psychedelic), some chromane derivatives of the common 2C compounds (Tarik Peterson prepared the chromane derivative of 2C-D iirc but hasn't tried it), some more 4-R-2,5-dimethoxyphenylpiperidines, and so on and so forth.

Unlimited hypothetical compounds like I said, but the actual viability of creating them is another story.
 
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