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Doxylamine - Effects & Uses -

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DoctorChemX

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( Note to mod, i got advice from drug_mentor who said i could start a new
thread on doxylamine, so please don't merge it with the super-old one, thx)

This compound is quite interesting to me, i've tried it many times, it certainly
puts me to sleep, combined with codeine, i sleep like a baby, it's a pretty potent
sleep-inducer(even though it's an anti-histamine) what do you guys think of it?

The most i ever took at once was about 150mg, what do higher dosages do? Experiences?

thanks guys.
doctorchemx
 
I havent taken it recreationally but have taken it to sleep many times. I find it ok for sleeping, though not as good as stilnox. the problem I have with it is that it makes me feel quite groggy the next day. this I believe is due to its long half life.

The most I believe I took was 100mg. I think it made me a little delirious and made me have a dream that freaked me out when I woke up because for a little while I thought it was real.
 
ahh thanks guys, yeah, i realized it doesnt have much
recreational effect, but it does work well on sleep, i use
it when i don't have anything else, as it calms me down. :)
 
As above: I use it when there's nothing else and it's an emergency (ie. I need to calm down or I'll go nuts), and even then I think twice.

Doxylamine isn't a subtle drug. For me, a single Restavit (25mg of doxylamine) hits my brain like a meteor. Sure, I slow down and go to sleep, but the quality of sleep isn't very good and I feel quite out of it for half of the next day. As Psytaco mentioned, delirium and disturbing dreams are common for me.

As I have no tolerance to benzos, a couple of milligrams of etizolam, or 20 to 30mg of temazepam provide a much smoother way to go to sleep/come down and leave me feeling fine and functional the next morning.
 
Halif said:
Doxylamine isn't a subtle drug
Click to expand...

Thats nice to hear man, i agree, sometimes when i take it, especially
if i take it with a beer, i feel really heavily sedated, like a stone, so it's
certainly not a weak drug, i have to use it now for a week, cause i have
no xanax left, i think it will keep me going with sleep, it usually works well.

peace
 
Halif said:
As above: I use it when there's nothing else and it's an emergency (ie. I need to calm down or I'll go nuts), and even then I think twice.
Click to expand...

Sums it up perfectly, not something you look forward to taking by any means - but it helps.

Not the best quality of sleep however, lots of tossing or turning for me. Havent been desperate enough to use this for sleep in years though.
Absolute last ditch resort, its half life must be huge seeing as your still well groggy half way into the next day. That makes it a bad choice as a day to day sleep aid.

150mg is extreme overkill, and I think you could stand to read some trip reports on deleriants before doing anything like that again. True hallucinations, the inability to tell whats real and whats not. Damn good way to wind up in jail or hospital :\

Most I've taken is 3 restavit (75mg?) and even then shit was getting a bit weird.

If you need chemical assistance to sleep on a nightly basis you really want to take this up with a GP. In my proffessional opinion I think seroquel has great potential in these situations, mostly due to it being non-abusable and EXTREMELY effective. You also get a rebound effect of dopamine and serotonin upregulation after it wears off, only slight but desirable none the less.

If your scripted xanax then you should know that this is only a short term fix, and in the long run all your going to get out of daily use is physical dependance to a drug that doesnt work anymore :!
 
Chiming in a bite late here, but thought I would comment as I had 50mg of Restavit (2x 25mg Doxylamine tablets) last night.

Some background info; I am not a good sleeper ordinarily so when I add stimulants to the mix I lose any hope of sleep, and as I am not a big fan of smoking grass, I naturally turned to alternative remedies. When I first started using stimulants I tried out Restavit, mostly because it was available over the counter but also because I wasnt fully aware of other Hypnotic's.

Until the day I was prescribed a Benzodiazepine (Diazepam) for an oversea's flight, I actually didnt even take it oversea's, the pills sat in my top draw at home for months until one day I decided to pop one on an mdxx come down and oh my, I remember that great warm feeling that went over my body as I laid in bed and just dozed off to sleep, and the best thing was I actually woke up feeling better then usual. That was 7 years ago and I have been lucky enough to have only required 3 scripts of Benzo's since then as I only ever really binge on stimulants on the rare occasion. The weekend that just passed being one of them, have fully known that I had ran out of Benzo's over a binge over xmas I decided to buy a packet of Restavit's. I took the 2 tablets Sunday night at 9pm following a 20 hour binge of MDXX & Amphetamine's, within around 20 minutes I felt uncontrollably tired. I put myself to bed and fell into an extremely solid deep sleep for around 10 hours. Now 24hrs since dosing I am reminded why Restavit is my least favorite Hypnotic, in theory its half life should be comparable to most benzo's but rest assure you feel the effects of Restavit for pretty much the entire following day. I know I have to take into account my actions from the weekend and that certainly contributes to how I feel today but when i compare a similar binge + benzo come down my recovery seems to be much quicker.

I cant believe someone mentioned they took 150mg, I hope you didnt drive or operate heavy machinery for at least 2-3 days after that, this afternoon I was toying with the idea of getting out of the house to get a coffee but I only made it to my front gate and felt dizzy and spaced out to even fathom the idea of getting behind the wheel. Furthermore I read that Restavit is regarded as a high dose already, in some countries the maximum they will sell OTC is 10mg tablets, personally I think its great that we can get a powerful sleeping tablets OTC, and I disagree with other comments that the effects of Restavit being worse then not sleeping at all, for me sleep is when my mind finally turns off and I can start the recovery process, but as already mentioned it should be used as last resort.

- Hmm I didnt intend on ranting on this long, sorry! :|
 
hmmm. Restavit never makes me sleepy yo.

i usually take it to potentiate /deter the nauseaness that comes with opis.

Now that I have a monster tolerance on opis, I dont get nausea's anymore.

So I haven' really taken restavit for a long time :)
 
This just goes to show how different everyone's brain chemistry is and how subjective the effects of any particular substance are:


Restavit never makes me sleepy yo.
Click to expand...


For me, it's more a case of:


within around 20 minutes I felt uncontrollably tired.
Click to expand...


"Uncontrollably tired" is a good description of the effects of doxylamine for me, and I'm also surprised that 25mg tablets are OTC here, given that they are both powerful and also have long-lasting side effects.


Why does it have to be the things I don't want that are OTC? It's not fair dammit!
 
Combined with codeine it goes really well, I make sure to get doxylamine separately as Restavit, rather then getting say Mersyndol Night Strength. It used to make me nod out a lot, it's easy to get a tolerance to the sedative effects though even quicker then benzodiazepines I found. Most I've taken was maybe 150mg, 175mg... that was with a tolerance.

Also has the added benefit of killing nausea.
 
Halif said:
"Uncontrollably tired" is a good description of the effects of doxylamine for me, and I'm also surprised that 25mg tablets are OTC here, given that they are both powerful and also have long-lasting side effects.


Why does it have to be the things I don't want that are OTC? It's not fair dammit!
Click to expand...

I agree 100%.. It makes me think that restavit will soon be a prescription only drug, begs the question do we stock up now or are the hang over effects too undesirable?
 
^ I doubt there is a big push to make doxylamine a prescription only drug... it would only be if it starts making waves in the media (see pseudoephedrine or codeine) that there would be pressure to change it's supply.
 
DoctorChemX said:
( Note to mod, i got advice from drug_mentor who said i could start a new
thread on doxylamine, so please don't merge it with the super-old one, thx)

This compound is quite interesting to me, i've tried it many times, it certainly
puts me to sleep, combined with codeine, i sleep like a baby, it's a pretty potent
sleep-inducer(even though it's an anti-histamine) what do you guys think of it?

The most i ever took at once was about 150mg, what do higher dosages do? Experiences?

thanks guys.
doctorchemx
Click to expand...


I have used it back in 2005 to put me to sleep, while I was on Tenuate Dospan ( Diethylpropion).
I took 2 Dozile liquid caps ( Doxylamine). ( Each has 25mg of Doxylamine in it).
The recommended dose is 2 caps.

But, for pain, I have tried Mersyndol ( Paracetamol 450 + Doxylamine Succinate 5mg + Codeine Phosphate 9.6mg).
The recommended dose is 2 tabs.
( But the amount of Doxylamine is only 10mg).

Beside Mersyndol, now they have Dolased, Priceline night time pain tabs, Amcal night time pain tabs, etc.
( All ingredients are Paracetamol 500mg + Codeine 10 + Doxylamine 5.1mg)

Funny enough, they put 450mg of Paracetamol in Mersyndol.
Also, in Dolased, they put 5.1mg of Doxylamine succinate.
Also, in Mersyndol they put 9.6mg, I guess it's for psychological thought that the amount seems huge, instead of the number 10mg.) Well, I have no idea , really .... :D
 
Grrrrr. I just made the mistake of asking my GFs bro to get me some STRONG painkillers, ie chemist own with codiene.
He got me Maxydol (500mg paracetamol, 10mg codeine and 5.1mg Doxylamine WTF?).

Obviously I didn't want Doxylamine. Anyone of the top of there heads know how water soluble this crap is.

I didn't need an anti-histamine, got periactin for that shit.
 
Mr Blonde said:
It used to make me nod out a lot, it's easy to get a tolerance to the sedative effects though even quicker then benzodiazepines I found. Most I've taken was maybe 150mg, 175mg... that was with a tolerance.
Click to expand...

Yeah I get massive tolerance to anti-histamines when I start using them for sleep again, if it's been a few months though sometimes they kick me in the arse.
 
Captain Brewster, sir, permission to report some bad news re doxylamine's solubility in water... ;)

It's soluble enough to make a big difference to your extraction. Don't use them. You'll need some 'normal' tablets without doxylamine.
 
jessv3 said:
I agree 100%.. It makes me think that restavit will soon be a prescription only drug, begs the question do we stock up now or are the hang over effects too undesirable?
Click to expand...

Prescription is more about abuse/addiction potential and how dangerous the medicine is. I've never heard of anitihistamine addicts. There's very limited abuse potential, when it is abused it's mainly school aged kids using them to trip [delerium] . But like most school kids, I used anti histamines for tripping once or twice. It's too unpleasant/frightening to bother with again.

I only ever had a problem buying antihistamines as a youth, as pharamacists are either trained or via word of mouth know youths have tried to trip on them in the past. I think REstavits are too lethargic to be ideal for this purpose though, it's mainly the travel sickness antihistamines that are used.
 
I find Unisom gels ( Diphenhydramine) 50mg is not as strong as 25mg Doxylamine

I popped 1 , and still awake.
 
^ Yeah doxylamine is the most sedating antihistamine in my experience.

bobbydarren said:
I've never heard of anitihistamine addicts.
Click to expand...

I once knew of a lady who was known among the local pharmacies for buying lots of doxylamine... apparently she was dependent on them for sleep, so the pharmacists were starting to stop selling to her in an effort to get her to see a doctor about the problem. From the point of view of the pharmacist, it's not that doxylamine is 'fun' and normally addictive (because it is neither of those things by itself really), but rather that this person obviously had a medical problem which needed the attention of a doctor.
 
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