I have to agree with LSDMDMA& that MDMA is far worse for you dose by dose than Meth amphetamine. Thing is the Methamphetamine life style can turn a whole lot shittier quicker, and people get into routines with using meth much faster than MDMA. How ever strictly speaking of taking JUST 1 dose of MDMA or Meth in a year, the MDMA would have caused more damage to your brain and cognition than the meth. Meth acts more primarily on the dopamine system which is much more resilient than the serotonin system which MDMA primarily works on (much more fragile). Not only that the spike of neurotransmitters MDMA releases at once is greater than methamphetamine, and once most of your serotonin is cleared out in your brain dopamine gets oxidized in the serotonin receptors which should never happens unless administered MDMA. One more thing to add is as you guys know a lot of the e pills' have amphetamine and meth cut into it which drastically increases neurotoxic affects ( as stated increase of dopamine while rolling is bad because they get pushed into the serotonin receptors , a big no no)