Opioids Does Grapefruit Juice Really Potentiate Oxycodone?

[crasspaddy82]

Does grapefruit juice really potentiate oxycodone? I tried benadryl (one 25 mg pill) last night with 30 mg roxi and I didn't really notice much.

 

[laCster]

to an extent, but the effects vary. tagamet (cimitidine) works close to 100% of the time at blocking 3A4. however, cimitidine inhibits 2D6 aswell, and thus does not mix well with opiate pro-drugs. (i.e. codeine, tramadol, DXM, ect..)

 

[crasspaddy82]

So what will it do? By how much does it potentiate?

 

[laCster]

drink 2 full glasses 30-60minutes prior to your dosage. it won't add to the euphoria, however gfj will extended the duration of effects.

 

[mrflowers00]

grapefruit juice really potentates benzos but i don't really notice a difference with opiate/opioid drugs

 

[Fire&Water]

Yeah you really can feel a 600 mg. dose of (Tagemet) prolong the duration of a moderate dose of oxycodone the first day but It's just like anything else if you dont break from it for a length - Tolerance will just kick yer' ass down.

 

[BrokedownPalace]

Remember that the enzyme inhibition only helps extend the duration of the high, not necessarily boost the intensity. Also, you must take the opiates orally, as insufflation/injection will bypass first pass metabolism and the enzyme inhibition will be rendered useless.

 

[crasspaddy82]

I don't know, I may just stick to high fat meals after my dose to potentiate it, a lot of threads and sites seem to say that works better. I have a lot of stomach issues and I think grapefruit juice might fuck with that.

 

[Thomas29]

I find it does extend the duration by a bit.