DMSO and aprazolam

[SVT]

I was thinking earlier, If i were to use dimethyl sulfoxide and mix it with powdered aprazolam (Xanax). Would I be able to just put the dimethyl sufoxide on my arm and have the aprazolam absorb into bloodstream though my skin?

 

[sekio]

DMSO is way too polar to dissolve alprazolam. Maybe midazolam.

Even then, I'd have my doubts about central activity.

 

[Swerlz]

Nope..

 

[Torabora]

why would you want to do that? so hard to swallow this little pills?

 

[SVT]

No, not hard to swallow at all. I was just curious to see if it would work, and the other poster was right...it hardly dissolved at all

 

[ampakine]

Have you tried converting it to a more soluble salt? Also what temperature was the DMSO when you tried to dissolve the alprazolam? I'm pretty curious about DMSO too. I have half a litre of the stuff so I might do some experimenting.

 

[sekio]

Alprazolam dopesn't form salts. It's a very lipophilic benzodiazepine.

 

[kakti]

Pure alprazolam will dissolve in heated 95% ethanol and very acidic water. No idea about DMSO solubility though.

 

[sekio]

DMSO is aprotic and polar. I'd say there's not a chance in hell. Ethanol is a lot less polar - DMSO is aabout the same as water.

 

[jmiller78]

Youre all wrong
, studies show. 30mg/mL solubility ib dmiso

 

[4DQSAR]

Ketamine is highly soluble in DMSO. I knew someone who really did consider dissolving K and putting the result into a water pistol. I disabused him of the idea - spiking people is never the right thing to do.