mitogen
Bluelighter
- Joined
- Nov 8, 2004
- Messages
- 127
in the sense that everything in pharmacology is largely bullshit...
care to elaborate on exactly why you think the generalised concept of a human reward pathway (providing comparisons to rat data,) being based on the mesocorticolimbic dopamine system is bunk?
does anyone know of any human studies (neurosurgery etc.) where subjects have actually had electrical stimulation of their VTA?
I had a quick look on pubmed under: "electrical stimulation" AND VTA but didn't find anything. hmm, papers from '2005' are already out.
anyway, the rat data (I havent seen any raw data, actually - just textbook stuff on reward circuits,) seems reasonably convincing... ie, rats self-simulating until death.
why does our analogous pathway not function the same?
how might the other DA pathways contribute?
care to elaborate on exactly why you think the generalised concept of a human reward pathway (providing comparisons to rat data,) being based on the mesocorticolimbic dopamine system is bunk?
does anyone know of any human studies (neurosurgery etc.) where subjects have actually had electrical stimulation of their VTA?
I had a quick look on pubmed under: "electrical stimulation" AND VTA but didn't find anything. hmm, papers from '2005' are already out.
anyway, the rat data (I havent seen any raw data, actually - just textbook stuff on reward circuits,) seems reasonably convincing... ie, rats self-simulating until death.
why does our analogous pathway not function the same?
how might the other DA pathways contribute?