Diphenoxylate - a non-analgesic opiate

[Illyria99]

I have taken high dosages of lomotil before and experienced definite opiate/analgesic effects. This is the first claim I know of that contends it is not an active narcotic.

Occasionally I get some of these, and they are AMAZING. I usually take about 30 of these little pills and an hour or so later I'm having the best nod in my life.

I. Love. These.

 

[beebopp]

Be careful:

Cardiac Arrhythmia Secondary to Loperamide Abuse and Toxicity - PMC

Loperamide is a synthetic, over-the-counter, antidiarrheal medication that is widely available and used for the treatment of diarrhea. It is a peripherally acting opioid agonist acting mostly on the μ-opioid receptors in the gut. It was thought to ...

www.ncbi.nlm.nih.gov

 

[fastandbulbous]

Be careful:

Cardiac Arrhythmia Secondary to Loperamide Abuse and Toxicity - PMC

Loperamide is a synthetic, over-the-counter, antidiarrheal medication that is widely available and used for the treatment of diarrhea. It is a peripherally acting opioid agonist acting mostly on the μ-opioid receptors in the gut. It was thought to ...

www.ncbi.nlm.nih.gov

Long QT syndrome. Quite a few opioids do that (why acetylmethadol was withdrawn for treating opioid dependancy)

 

[izo]

Long QT syndrome.

heard that about methadone for example.

 

[Fertile]

Long QT applies to oxycodone, tramadol, methadone and quite a few others. I didn't appreciate the risk until it was pointed out.

 

[Pissed_and_messed]

there was one study that implicated that loss of executive control and motoric issues are caused of alcohol metabolite
can't believe it is the whole truth but makes sense.

 

[Fertile]

I think it's ethanol itself - or specifically GABA a1b1y2 receptor agonists. That's why people sometimes take Z-drugs and go crazy. Some benzos can do it, but the Z-drugs are the worst of all.

 

[izo]

That's why people sometimes take Z-drugs and go crazy.

read of one case in the usa, someone sleeping on zolpidem began sleepwalking and in his sleep killed his neighbour i believe. no charges pressed because it seemed to be zolpidems fault.

 

[Fertile]

read of one case in the usa, someone sleeping on zolpidem began sleepwalking and in his sleep killed his neighbour i believe. no charges pressed because it seemed to be zolpidems fault.

I don't know about US law, but UK law recognises the 'automaton' state people can enter. Of course, UK law is based on 'mens rea' i.e. 'guilty mind'.

 

[fastandbulbous]

Long QT applies to oxycodone, tramadol, methadone and quite a few others. I didn't appreciate the risk until it was pointed out.

All opioids with significant NMDA antagonist activity. I do hope that's not the reason...

 

[Fertile]

Well neither levorphanol nor ketobemidone are logged for LongQT. Of course, they are quite rare.