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Diphenoxylate - a non-analgesic opiate

Morninggloryseed said:
I have taken high dosages of lomotil before and experienced definite opiate/analgesic effects. This is the first claim I know of that contends it is not an active narcotic.
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Occasionally I get some of these, and they are AMAZING. I usually take about 30 of these little pills and an hour or so later I'm having the best nod in my life.

I. Love. These.
 
beebopp said:
Be careful:

Cardiac Arrhythmia Secondary to Loperamide Abuse and Toxicity - PMC

Loperamide is a synthetic, over-the-counter, antidiarrheal medication that is widely available and used for the treatment of diarrhea. It is a peripherally acting opioid agonist acting mostly on the μ-opioid receptors in the gut. It was thought to ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Long QT syndrome. Quite a few opioids do that (why acetylmethadol was withdrawn for treating opioid dependancy)
 
there was one study that implicated that loss of executive control and motoric issues are caused of alcohol metabolite
can't believe it is the whole truth but makes sense.
 
I think it's ethanol itself - or specifically GABA a1b1y2 receptor agonists. That's why people sometimes take Z-drugs and go crazy. Some benzos can do it, but the Z-drugs are the worst of all.
 
Fertile said:
That's why people sometimes take Z-drugs and go crazy.
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read of one case in the usa, someone sleeping on zolpidem began sleepwalking and in his sleep killed his neighbour i believe. no charges pressed because it seemed to be zolpidems fault.
 
izo said:
read of one case in the usa, someone sleeping on zolpidem began sleepwalking and in his sleep killed his neighbour i believe. no charges pressed because it seemed to be zolpidems fault.
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I don't know about US law, but UK law recognises the 'automaton' state people can enter. Of course, UK law is based on 'mens rea' i.e. 'guilty mind'.
 
Well neither levorphanol nor ketobemidone are logged for LongQT. Of course, they are quite rare.
 
I’m gonna necro this thread to say something I think is important these days. Mods, I hope that’s ok…

With how difficult it is to get off fentanyl and specifically to bridge 24-48 hours for suboxone induction, I found lomitil to be invaluable. This medication is fairly easily obtained and could absolutely be used to reduce the chance of precipitated withdrawal during suboxone induction. I’m a fentanyl addict (smoking ~1g/day for 6 months) who’s been trying to quit for the past couple months but struggling with making it through the initial 2 days before inducing suboxone.

I’ve had a lomitil script for years. Yesterday I ran out of fent and tried lomitil as a replacement. To my surprise it held me incredibly well at only 8 pills, so 20mg diphenoxylate. I was not only not sick but actually opiated, for hours. It held me better than plugging morphine at 15-30mg, which I had to do at least 3x daily to abate withdrawal. It almost felt better than smoking fentanyl… I wonder if it has something to do with the fact that it’s a phenylpiperadine based opioid. It reminded me of methadone with regards to fentanyl replacement.

I’ve used lomitil recreationally in the past but never relied on it as a replacement. I was thoroughly surprised and now feel like I have an adequate supply of an appropriate medication to bridge me to suboxone induction.
 
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