The irony is...well, it's palpable.

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Does anyone have respective EC50s for l-meth and d-amp handy? I am currently stuck behind paywalls, but I want to say that l-amp is a good bit more potent and slightly less selective for NE than l-meth, suggesting it a poor substitute.
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People need to shed their dogmatic opposition to norepinephrine release. NE plays a key role in many of stimulants' desired effects, particularly increased alertness and arousal. As a telling empirical example, ethcathinone, as a selective norepinephrine releaser, seems pretty fun and useful, with a time-course and potency that can't be explained by catabolism to cathinone. And then highly selective dopamine reuptake inhibitors seem more like selective 'compulsogens' than euphoriants or functional stimulants.
ebola