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Misc Desperately need a new antidepressant

Like you, I've been taking a whole host of anti-depressants for over 8 years. I'm currently taking a break (hopefully a long one) but I've definitely found that most anti-depressants are only good for a year, then I have to change to a new one. Then I normally taper once a year to check my 'normal head', which I'm doing at the moment.
 
Maybe talk to your doctor about an atypical antipsychotic called seroquel which is a drug with heavily sedating properties and is usually taken before bed when prescribed to people without any form of psychotic disorder (such as schizophrenia). Whilst i was a resident in a drug treatment center i was prescribed it for anxiety and depression. I found the drug to work very well in both respects and even tackled my occasional insomnia. During the period in which i took seroquel i weighed 120 lbs and took 100mg 30 minutes prior to bed. Talk to your doctor about possibly utilizing this medication. It may take some convincing because for the most part seroquel is classified as an anti psychtic and some doctor may not be too inclined to prescribe a drug for an off label purpose unless you see a licensed psychiatrist,
 
It sounds to me like a lot of you guys are relying solely on a substance to cure your depression. medications are only half the battle; you need therapy and you need to make changes to your life and your life style and address the core issues that lead to your depression, and meds are supposed to be used to catalyze these changes, to get you over the initial hump and out of bed to face your challenges.

and I'm not judging here or saying this applies to anyone here but I know so many people who use substances rather frequently, even something as 'benign' as weed and they totally disregard the fact that their substance use aids in or even catalyzes their depression without them even realizing it (or choosing to be ignorant of it), and then they get jacked up on antidepressants and other shit all the while still wanting to continue their substance using lifestyles, not changing a god damn thing but just jacking their fucking brains up until nothing helps

this quote says it well
Juicy J said:
The key to success nigga, is hustlin, and that's it. Real talk you know hands down nigga. See, the key to success is hustlin my nigga. You know get that mother fuckin wax out your mother fucking ears nigga, you know what im sayin? You high all day, you layin down all day - nigga I do the same shit but nigga I hustle. So I'ma tell you niggas once again for you dumbass niggas: the key to success nigga is hustlin. Nigga get your ass up off the mother fuckin bed nigga. Bed bug lookin ass nigga
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Take your meds, take your drugs, but fuckin hustle, make changes, make that paper, make yourself happy, get the fuck out of your rut, only YOU can do it, aint no med gonna do it for you
 
OP might be able to go on Selegiline. You'll have to cut your dex-amp back to the microgram range at first, and then slowly raise the dose (as per the wiki).

I'm a huge Selegiline fan, and personally have been able to use for stimulant potentiation+neuroprotection without adverse effect.
 
Update

It seems I wandered away from BL for a while and forgot about this thread. Let's just say that a lot has happened in the meantime. I figure an update is in order.

I'm still on the same doses of lamotrigine, aripiprazole, etc. as before. The only real change has been the mirtazapine.

I'm at 45 mg / night of mirtazapine, and it's worked wonders. I used to have lots of bad intrusive thoughts; the mirtazapine eliminated those. For example, I'd be sitting in my room, listening to some guys cutting the grass outside. My thought process would go as: that sound is loud and annoying, there are guys outside cutting the grass, if they're doing that they must have jobs, I have no job at the moment, I must be worthless, the world would be better off without me... That kind of thing. But those thoughts are fading memories now.

Mirtazapine also helped with the depression quite a bit, but over the last few months, I've slid back down. Not nearly as bad as before (no suicidal ideation or anything), but definitely in a slump. I don't know where to go from here. If you happen to want a taste of what my baseline has been for the last year or so, see this thread.

I can't say much about weight gain due to some physiological issues, but I think I'm slowly gaining some fat around my stomach.

As for therapy: I've been seeing various therapists all along, but I think I have reached the limit of what psychotherapy can do for me. At this point, it feels like I'm listening to a motivational speaker talking to a brick wall.

Finally, alcohol: I could write a book about this. The less said, the better. I really should have heeded R(x)AGE's advice to stay the hell away, but it's a little late for that now.

In conclusion, mirtazapine really helped, but not quite enough. Thank you all for your help in my time of need.
 
Cyanoide said:
Bakın, depresyon rastgele antidepresan seçerek tedavi edilebilecek bir şey değil. 10 yıldan fazla önce şiddetli depresyon, panik bozukluğu, yaygın anksiyete bozukluğu ve obsesif-kompulsif bozukluk teşhisi kondu bana. Yıllar boyunca bazen yürüyen bir eczane gibiydim; birçok farklı antidepresan (SSRI'lar/SNRI'lar/NaSSA'lar/Trisiklikler), antipsikotik (olanzapin/ketiapin), beta bloker (propranol, atenolol, bisoprolol), benzodiazepin (oksazepam, alprazolam, diazepam, klonazepam ve şu anda yoksunluk dönemindeyim) ve diğerleri (Lyrica, 5-HTP, St. John's Worth, GABA, Kava Kava, Rhodiola, İnositol, Melatonin vb.) kullandım. Ama ilaçların sadece belli bir yere kadar işe yaradığını, asla gerçek bir tedavi olmadığını fark ettim.

Ancak size bir antidepresandan bahsetmek istiyorum; mirtazapin. Etki mekanizması oldukça benzersizdir ve SSRI'lara benzemez. Uyku için son derece etkilidir, çok güçlü yatıştırıcı etkileri vardır (neredeyse antipsikotikler gibi), ancak bu etkiler birkaç hafta sonra azalır. Genellikle SSRI'ların işe yaramadığı tedaviye dirençli depresyonda kullanılır. Ancak hakkında daha fazla bilgi edinmeye çalışın, yan etkileri yok değil. İlk haftalarda aşırı halsizlik ve tatlı/yağlı yiyeceklere karşı aşırı istek beklenmelidir ve bu nedenle sıklıkla aşırı kilo alımına neden olur. Şeker bağımlısı bir balinaya dönüşmek istemiyorsanız, bu ilacı kullanırken isteklerinizi kontrol etmeyi öğrenmelisiniz. Ancak benim deneyimime göre SSRI'ların birçok yan etkisine sahip değil.
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MADULA-- Favrin buspani zayıf fitse proporsiyon yatarken yemeron renkli reçete 0 kilo HOŞUNA GİTMEDİ TABİ varsa ve surdurmak mümkün değilse vur dibine İYİMİ BÖYLE...:) -- Cuheyla İdrareken Bizikoyatri mutehassısı--
 
Depo-Testosterone 200mg IM is the BEST antidepressant ever………study participants did cardiovascular exercise for 45min…..elevated levels of Phenylethylamine metabolites were in high levels in their urine samples

Phenylethylamine is your bodies natural Amphetamine……regulates monoamine (Dopamine, Norepinephrine, Serotonin) also cannabinoids and endorphins (bodies natural Opioids)

Healthy diet, daily exercise (even 30-45min brisk walk speed walk or run, fresh air sunshine, social interactions with friends and family, Sex……all AMAZING natural antidepressants

F@CK SSRI meds and all that B.S.

Go to family doc, get blood work done to test free testosterone levels checked……I personally have a script of depo-Testosterone 10ml vial / 200mg per ml ……incredible mood-boosting antidepressant properties, increased energy vigilance, confidence, happy outgoing friendly interactions with random people.

A healthy diet, exercise and social interactions that are fulfilling…..mentally, emotionally and spiritually

LSD 100ug standard dose on a summer day, beautiful sun shinning, swimming in Mother Nature with close friends, fire 🔥 at night nice music, stars sparkling like diamonds …..it’s a therapeutic love making experience for your soul

Step back from Rx pharmaceuticals and turn to nature and specific compounds and positive energy I outlined

Be well friends :)
 
Tianeptine is pure mu-opioid agonist - addictive.
Suboxone - opioid ( addictive ).
Mirtazapine Is good for mood but it really makes you fat.

New atypical antidepressants are interesting, vortioxetine cured my depression ( it doesn't make me high or happy just makes me more immune to depression) and it doesn't stop working like old ssri's, i take it for years and it is absolutely effective. But starting was rough.

Don't try tramadol - actually one of the best antidepressants but addictive ( opioid + closely related to venlafaxine which u didn't like ).

But meds won't turn your life into paradise, they can help u for sure feel better but sometimes they do the opposite.
 
Finding the right medication is a crapshoot, unfortunately trial and error is the only way to know what works best for you.
 
M!$TER-ED said:
Finding the right medication is a crapshoot, unfortunately trial and error is the only way to know what works best for you.
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100% this.

It is incredibly draining working your way through shitty drug after drug and dealing with the side effects. But when you find one that works it's pretty good. Life isn't amazing suddenly. You're just able to function again. And slowly get back to enjoying life.

I always find smoking some weed balances me out some. Medical cannabis is legal now in many countries.

BB
 
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