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Misc Desperately need a new antidepressant

Like you, I've been taking a whole host of anti-depressants for over 8 years. I'm currently taking a break (hopefully a long one) but I've definitely found that most anti-depressants are only good for a year, then I have to change to a new one. Then I normally taper once a year to check my 'normal head', which I'm doing at the moment.
 
Maybe talk to your doctor about an atypical antipsychotic called seroquel which is a drug with heavily sedating properties and is usually taken before bed when prescribed to people without any form of psychotic disorder (such as schizophrenia). Whilst i was a resident in a drug treatment center i was prescribed it for anxiety and depression. I found the drug to work very well in both respects and even tackled my occasional insomnia. During the period in which i took seroquel i weighed 120 lbs and took 100mg 30 minutes prior to bed. Talk to your doctor about possibly utilizing this medication. It may take some convincing because for the most part seroquel is classified as an anti psychtic and some doctor may not be too inclined to prescribe a drug for an off label purpose unless you see a licensed psychiatrist,
 
It sounds to me like a lot of you guys are relying solely on a substance to cure your depression. medications are only half the battle; you need therapy and you need to make changes to your life and your life style and address the core issues that lead to your depression, and meds are supposed to be used to catalyze these changes, to get you over the initial hump and out of bed to face your challenges.

and I'm not judging here or saying this applies to anyone here but I know so many people who use substances rather frequently, even something as 'benign' as weed and they totally disregard the fact that their substance use aids in or even catalyzes their depression without them even realizing it (or choosing to be ignorant of it), and then they get jacked up on antidepressants and other shit all the while still wanting to continue their substance using lifestyles, not changing a god damn thing but just jacking their fucking brains up until nothing helps

this quote says it well
Juicy J said:
The key to success nigga, is hustlin, and that's it. Real talk you know hands down nigga. See, the key to success is hustlin my nigga. You know get that mother fuckin wax out your mother fucking ears nigga, you know what im sayin? You high all day, you layin down all day - nigga I do the same shit but nigga I hustle. So I'ma tell you niggas once again for you dumbass niggas: the key to success nigga is hustlin. Nigga get your ass up off the mother fuckin bed nigga. Bed bug lookin ass nigga
Click to expand...

Take your meds, take your drugs, but fuckin hustle, make changes, make that paper, make yourself happy, get the fuck out of your rut, only YOU can do it, aint no med gonna do it for you
 
OP might be able to go on Selegiline. You'll have to cut your dex-amp back to the microgram range at first, and then slowly raise the dose (as per the wiki).

I'm a huge Selegiline fan, and personally have been able to use for stimulant potentiation+neuroprotection without adverse effect.
 
Update

It seems I wandered away from BL for a while and forgot about this thread. Let's just say that a lot has happened in the meantime. I figure an update is in order.

I'm still on the same doses of lamotrigine, aripiprazole, etc. as before. The only real change has been the mirtazapine.

I'm at 45 mg / night of mirtazapine, and it's worked wonders. I used to have lots of bad intrusive thoughts; the mirtazapine eliminated those. For example, I'd be sitting in my room, listening to some guys cutting the grass outside. My thought process would go as: that sound is loud and annoying, there are guys outside cutting the grass, if they're doing that they must have jobs, I have no job at the moment, I must be worthless, the world would be better off without me... That kind of thing. But those thoughts are fading memories now.

Mirtazapine also helped with the depression quite a bit, but over the last few months, I've slid back down. Not nearly as bad as before (no suicidal ideation or anything), but definitely in a slump. I don't know where to go from here. If you happen to want a taste of what my baseline has been for the last year or so, see this thread.

I can't say much about weight gain due to some physiological issues, but I think I'm slowly gaining some fat around my stomach.

As for therapy: I've been seeing various therapists all along, but I think I have reached the limit of what psychotherapy can do for me. At this point, it feels like I'm listening to a motivational speaker talking to a brick wall.

Finally, alcohol: I could write a book about this. The less said, the better. I really should have heeded R(x)AGE's advice to stay the hell away, but it's a little late for that now.

In conclusion, mirtazapine really helped, but not quite enough. Thank you all for your help in my time of need.
 
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