This report estimates taking datura with an MAO-inhibitor could increase the effects by many times. Taking diphenhydramine, another anticholinergic, with MAO-inhibitors increases the uncomforatable side effects. The only good thing that I imagine might result from taking ayahuasca with datura is that the user might puke up both before things really developed.Ayahuasca AND datura? that sounds... interesting. Think they might cancel each other out trip wise a little though...