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Opioids Daily use of demerol

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I dont know if anything can be guaranteed to make you sleep. i would take two and maybe a few ounces of hard liquor. but i drink every day so maybe 3 pills would be a better way for you to try to get some sleep.
 
liquor is the devil for me. I just took two, in an hour or so if needed I'll take another. thank you everyone.
 
randmanq said:
While doing some reading, I came across this:

"Normeperidine (an active metabolite and CNS stimulant) may accumulate and precipitate anxiety, tremors, or seizures; risk increases with preexisting CNS or renal dysfunction, prolonged use (>48 hours), and cumulative dose (>600 mg/24 hours). Oral meperidine should not be used since first-pass metabolism decreases efficacy while increasing normeperidine concentrations"

Is this metabolite just related to oral doses? Would this still build up if doses are sniffed?

Sorry, just confused.
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Yes, finally this is mentioned... You got so many answers and you answered yourself...

Prolonged usage of pethidine (meperidine) causes norpethidine cumulation. It's neurotoxic. You can get seizures, tremor, and in extreme cases serotonin syndrome when you mix pethidine with some serotonergic drug. No matter what ROA you choose, this happens.
 
I've been using 300-500mg a day for about 7-10 days now. I'm guessing I should stop? It's so difficult when it's the only thing I have for withdrawals. I was scared shitless by the tremors last night, but I've already used 150mg today. Waking up is so difficult otherwise.

Should I just lower my dose down big time, or would that be kinda useless?
 
Of course you should stop using it... do you really think after its been clearly explained why this is dangerous that anyone is going to advocate it?

If there is absolutely nothing else, you can always stock up on codeine, loperamide and other available drugs to help mitigate the withdrawal symptoms or even consider a detox program or at least seeing a doctor for some medication such as clonidine. There are always the methadone and buprenorphine routes also.
 
Another thing I noticed, was the tremors (or just muscle twitches) only happen when I'm laying down ready to nap. If this was related to norpethidine cumulation wouldn't I get these tremors all day long?
 
^as I said before, that sounds like hypnic/myoclonic jerks which are most common when people are falling asleep and exacerbated by drugs such as opioids... but even if THAT symptom is benign, it doesn't mean your use is not putting you at risk.
 
I was more wondering if it would be useless to lower my usage, any amount must be stopped. I have 60mg codeine pills/300 apap.

How many of these should be suitable for someone who could sniff around 300mg demerol for a dose?
 
When I sniff enough of it, I get a buzz. But the use is just to feel better in general.

I always though codeine would be much less effective to hold withdrawals off than demerol?
 
Also, with the body tremors associated with demerol use, these would happen all day wouldn't they?
 
randmanq said:
When I sniff enough of it, I get a buzz. But the use is just to feel better in general.

I always though codeine would be much less effective to hold withdrawals off than demerol?
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Well yeah of course demerol is more potent than codeine. But i'm sure if you took enough codeine you could get well. Like 500mg+ type thing.(don't go taking heaps like that before testing smaller amounts just because of codeines histamine release which can be severe)

It's not just about which drug is stronger man, demerol is a quirky opioid with a weird toxicity compared to most other drugs of the same class...

But if you only plan on using demerol for like another week or two i don't think you're in trouble per say, i think it's more an issue say if demerol was your d.o.c or only opioid you could get for extended periods of time, like months at a time.

So probably best to think of pethidine that way, best not used for long stretches. But it's your body, you can do what you want dude.
 
Yea today is my 7th day in a row using demerol. So it takes a few weeks for norpethidine cumulation? I'm getting more oxy on saturday or sunday.

I guess I could keep it safe and just dose 200-300mg to get on better at work, and just take sleeping aids at night.
 
You certainly can take it for more than two days in a row, but as others have mentioned, at those doses you're adding a toxic metabolite when you take it for longer periods of time. Best to play it safe. However, if you're getting other opiate somewhat soon you should be fine.

Bring your dose down as low as you can have it at while still being comfortable. This will minimize the chances of there being negative side effects.

That being said, I still agree that even codeine would be best for you if you're trying to prevent withdrawal. But yeah, its your choice. LONG (and I mean LONG) term use is a bad idea.
 
randmanq said:
Hello all. So my oxy connection has run dry for a while, and all I've been able to get these past few weeks was demerol. Now I know the talk of seizures and such with daily use, but how common is this? Is it just associated with oral doses?

I don't get high from it, all it does is keep the withdrawals at bay. But the past couple nights I've been getting a few tremors while laying in bed. Some small, some my whole body. Is concerning to me.

While I know continuing to use it is a stupid idea, is there any safer way to administer the drug? If it helps, I always sniff it.

Thank you
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oral and nasal BA is really low for demerol. even opiate naive, i didn't feel anything when i took two orally.. then i plugged 2 and it made a world of difference (i felt slightly buzzed). combined with hydrocodone it helped me relax and sleep
 
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