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Mental Health Coming off Invega Sustenna (Paliperidone) v3

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Sbar25 said:
How do people get through this its like everything is hard to enjoy even taking a nap impossible it sure takes away insane thoughts it make everything unbearable the simple things in life now suck
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do you talk to yourself a lot?
 
This is essentially a support thread!

One of your piers has vented concerns about this medication and rather than take these comments into wise consideration you've exacerbated them!
 
iridescentblack said:
This is essentially a support thread!

One of your piers has vented concerns about this medication and rather than take these comments into wise consideration you've exacerbated them!
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Hey can we stay on topic buddy? Sorry you feel that way it wasn’t intended. God will HEAL us all in Time 🙌
 
Ghostv2314 said:
Yeah our stories are similar. I’ve enjoyed reading your posts, they gave me hope on bad days. I plan to stick around after I recover as well. It really helps when you’re struggling to see other people say they actually recovered and can enjoy life again.

Also for the person who asked, yes I’m in my early twenties. I’m 25. The most depressing thing before I started to recover was thinking that my life was basically over from such a young age. There’s no way in hell I could manage to live 50+ more years under the full effects of Invega. That’s a punishment worse than death.

It reminds me of the story of Rosemary Kennedy, John F. Kennedy’s sister. She was lobotomized in her early twenties for basically bad behavior, they didn’t want her to embarrass the family name. This is back when lobotomies were still a thing. She was so disabled afterwards that she couldn’t even talk anymore. They dropped her off in a home for the disabled and she had to live her whole life out like that until she was 86. That’s horrible. These are the kind of depressing stories I was looking at all day when Invega was at its worst lol.
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Good information man, never knew that. And yes I also remember feeling the same way. Like literally not existing at all is better than Invega. What a shitty ultimatum. You’ll get well soon, sounds like you’re past the worst of it.
 
Is there a moment during recovery when one day you notice that you are feeling a lot better?
I'm hoping one year from now invega doesnt register in my thought process but it has taken so much from me i will probably always have trauma thinking about how it probably ruined my life
 
Sbar25 said:
Is there a moment during recovery when one day you notice that you are feeling a lot better?
I'm hoping one year from now invega doesnt register in my thought process but it has taken so much from me i will probably always have trauma thinking about how it probably ruined my life
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You won't. It'll be like a bad dream you woke up from.
 
That's what I'm hoping for sometimes when people say they didn't fully recover it bothers me. When people say 99% it worries me it doesnt make sense once the poison leaves the body it should return? The theory that the brain adjusts to invega levels permanently doesnt make sense it's like drinking alcohol permanently sedated your brain.
I just wanna feel better I wanna actually feel joy and love for basic life again.
Hardest experience of my life.
 
Sbar25 said:
That's what I'm hoping for sometimes when people say they didn't fully recover it bothers me. When people say 99% it worries me it doesnt make sense once the poison leaves the body it should return? The theory that the brain adjusts to invega levels permanently doesnt make sense it's like drinking alcohol permanently sedated your brain.
I just wanna feel better I wanna actually feel joy and love for basic life again.
Hardest experience of my life.
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Cognitive functions, emotions, physical strength and such will be resolved over time. Supernormal abilities are some of the last things you will recover.
 
No psych drug is capable of staying in your body forever. You'll get better with time.

That said, arguably one could say that the whole "Sustenna" part of the Invega, i.e. the use of a long-lasting fatty acid ester of paliperidone in a depot injection, is the closest you'll get to a poison that makes paliperidone stay in your body for long periods of time. (that is: by binding the paliperidone to a fat molecule, it forms a compound that slowly breaks down and releases the paliperidone over time.)

Even drugs that are designed to permanently bind to receptors do not have permanent effects - your body does replace receptors on the cell surface, albeit slowly.
 
I thought sustenna gets lodged into the muscle tissue and stays in the muscle so it then goes into your bloodstream and stores in your fat?
 
That's correct. Initially the paliperidone palmitate will accumulate in the muscle, and then will diffuse to the body fat. But don't confuse a compound being dissolved in fatty tissues, with being chemically linked to a fat molecule. They are two seperate things.

The paliperidone palmitate - which is what was injected - is not the same as "free" paliperidone. It's composed of paliperidone, with a big fat molecule glued on, making it want to dissolve into fat. As the paliperidone palmitate slowly diffuses back out of fat into blood, enzymes (called lipase enzymes) in your blood and tissue break it down, into palmitic acid (a fat), and paliperidone (the active antipsychotic). This is why the effect isn't instantaneous after receiving an injection, actually!

Don't worry though, as the fat molecules can't get re-stuck on there. And paliperidone can't last forever in your blood stream. Any paliperidone that is liberated by lipase enzymes will eventually be metabolized and excreted. As time goes on, there will be less and less paliperidone palmitate remaining, so levels of "free" paliperidone will fall. Eventually there will be only traces left, and you will be back to normal.
 
Can someone tell me if I'll need to lose weight to get Invega completely out of my system?

I'm concerned that Invega is going to processed out of my system, and then when I lose weight, the fat that stores Invega will be burned and Invega will be released into my system again. That's not how it works, is it? Someone please fill me in if you can.
 
sekio said:
That's correct. Initially the paliperidone palmitate
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what would you say about 6 months of oral Abilify, with very little body fat to begin with? Is the neuroleptic induced deficit syndrome caused exclusively by the drug still being in my system? Not a brain change?
 
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