• The Dark Side 💕 Welcome Guest 💕
    Posting Rules Bluelight Rules
    Notable Threads Urgent Hotlines
    Bereavement Mindfulness
    Suicide Support Anger Management
  • TDS Moderators: AlphaMethylPhenyl | paranoid android

Mental Health Coming off Invega (Paliperidone, Xeplion) injections v. 7.0

Status
Not open for further replies.
dirtyinvega said:
I truly don't know if anyone has fully recovered someone must off or some people I only know my story. It is hell mate this drug but I truly have come to terms it is what it is and I have moved on because what can one do I don't have a "Time machine" to go back in time and change things.
Click to expand...
I’ll be honest with you, I was never in «hell» like many of the users here experienced. I think the side effects suck, but am still able to work, exercise, socialize and I just took an IQ test related to a job in which I did well. I sleep well, eat healthy, and I’m content in general.

The only side effects I still suffer are below the belt and substances, to some degree. I’ve had improvements, but it would be a huge blow if I don’t recover 100% in this regard, especially the D. Would push for trt if that doesn’t resolve.

I really think recovery is possible, but I’m worried it’s not going to be 100%. I’m not in my twenties anymore. I guess time will tell, no point in dwelling about it too much.

keepinghope said:
Guys most people recover. Maybe not 100% but it’s night and day compared to the first few months. How can you even ask that question. Why would people come back and say they are functioning unless they truly were. Even with @dirtyinvega the fact that he has kids and a functional life, even tho saying not 100%, that is still proof of being out of the original hole.
Click to expand...
I’m curious about his opinion, why are you triggered by that? I don’t necessarily agree with him, but it’s important to hear different views than your own as well. He is a vet after all. Not every day we hear from old users.
 
Maymay169 said:
Does anyone else find themselves basically counting the hours until they can sleep? I check the clock at least once an hour waiting for the time to pass so I can escape from invega hell… this is no way to live, how long will it be like this? Can any survivors relate to this?
Click to expand...
God, yeah. It gets better when you can make yourself do things to color in your day.

I'm really surprised ginko supplements aren't getting any attention! They have cured peoples' PSSD, why not the shit antipsychotics do? And at least some of the genital numbness is caused by erectile tissue problems, some of it is caused by blocked pleasure centers. It's also good for neurons, it is neuroprotective, but it doesn't promote neurogenesis. It just improves communication between braincells and stimulates neurons. It's good for the whole nervous system.
 
Last edited:
Maymay169 said:
Does anyone else find themselves basically counting the hours until they can sleep? I check the clock at least once an hour waiting for the time to pass so I can escape from invega hell… this is no way to live, how long will it be like this? Can any survivors relate to this?
Click to expand...
Yeah May I was kinda like this, I wanted to sleep everyday to escape the feelings from Inevga, cause sleeping and dreaming made me feel normal like pre-invega. Im just curious when I recover. And then when I sleep and dream am I gonna some days feel like im on invega awh hate to have those dreams thats pure nightmare
 
Serhat96 said:
Thanks to Structural Plasticity our brain's structure, such as the growth of new neurons (neurogenesis), the formation of new synaptic connections between neurons (synaptogenesis), and the pruning or elimination of unused connections (synaptic pruning).
Click to expand...
I studied neurology. Antipsychotics severe the connections you've made you don't get those old connections back, they don't grow back in the same manner as well. This doesn't mean you lose all your connections in all brain parts. Antipsychotics shrink the brain and reduce gray matter, that grey matter doesn't magically grow back. Plasticity means that certain brain parts and connections will take over function and connectional function of other brain parts. After antipsychotics you get a whole different blue print where you start making new connection upon, the original brain /blueprint is gone.

Most people who are paralyzed and in a wheelchair by spinal damage or people with severe brain damage will have damage for the rest of their lives. Most of them do not magically stand up one day and start walking again it's a very tiny minority who do get better just a few % at most. I understand you people want hope but you have to be realistic here. Does this means you don't heal ? No.... you do heal but only certain areas in certain brain parts. Armchair scientists need to stop promoting the lie that plasticity means your whole brain regenerates.
 
Last edited:
Alex07 said:
I studied neurology. Antipsychotics severe the connections you've made you don't get those old connections back, they don't grow back in the same manner as well. This doesn't mean you lose all your connections in all brain parts. Antipsychotics shrink the brain and reduce gray matter, that grey matter doesn't magically grow back. Plasticity means that certain brain parts and connections will take over function and connectional function of other brain parts. After antipsychotics you get a whole different blue print where you start making new connection upon, the original brain /blueprint is gone.

Most people who are paralyzed and in a wheelchair by spinal damage or people with severe brain damage will have damage for the rest of their lives. Most of them do not magically stand up one day and start walking again it's a very tiny minority who do get better just a few % at most. I understand you people want hope but you have to be realistic here. Does this means you don't heal ? No.... you do heal but only certain areas in certain brain parts.
Click to expand...
Source? Not a source saying ap’s reduce gray matter, we all know that MAY happen if you’re on them for a long time.

«Antipsychotics severe the connections you've made you don't get those old connections back, they don't grow back in the same manner as well.»

^this
 
Alex07 said:
I studied neurology. Antipsychotics severe the connections you've made you don't get those old connections back, they don't grow back in the same manner as well. This doesn't mean you lose all your connections in all brain parts. Antipsychotics shrink the brain and reduce gray matter, that grey matter doesn't magically grow back. Plasticity means that certain brain parts and connections will take over function and connectional function of other brain parts. After antipsychotics you get a whole different blue print where you start making new connection upon, the original brain /blueprint is gone.

Most people who are paralyzed and in a wheelchair by spinal damage or people with severe brain damage will have damage for the rest of their lives. Most of them do not magically stand up one day and start walking again it's a very tiny minority who do get better just a few % at most. I understand you people want hope but you have to be realistic here. Does this means you don't heal ? No.... you do heal but only certain areas in certain brain parts. Armchair scientists need to stop promoting the lie that plasticity means your whole brain regenerates.
Click to expand...
Idk what you talking about armchair scientists but what I said wasnt a made up lol. And I want to note another thing, your brain doesnt get paralyzed and puts you into a wheelchair by taking antipsychotic the comparison you gave is totally irrelevant. You seem to have emerged out of nowhere, I read your previous activity and you havent introduced yourself or told us you been injected and battling with side effects. Idk if I should believe what you said someone who studied neurology I highly doubt theyd be injected with invega. Basically what im trying to say is your a noob you claim to know about neuropathic brain structure but you answered a question to a rhetorical question.
 
Last edited:
@Baddream The whole time since going though this nightmare invega hell. I do some sorta theory what happened to me and why I'm on the extreme side of the scale. I have had ADHD all my life and because of that the brain has massive amounts of dopamine transporters and lack dopamine already and when invega come along and blocked the dopamine receptors suddenly the lack of dopamine in the transporter is even more effected and when I started back again on ritalin because of it been a reuptake inhibitor it has helped somewhat but not massive amounts like before invega and also been left handed and most parma drugs only tested on mostly right handed makes it even worse most drugs are designed for right handed brains. Plus ADHD people have massive chances or greater chance of getting Parkinson's.
 
dirtyinvega said:
@Baddream The whole time since going though this nightmare invega hell. I do some sorta theory what happened to me and why I'm on the extreme side of the scale. I have had ADHD all my life and because of that the brain has massive amounts of dopamine transporters and lack dopamine already and when invega come along and blocked the dopamine receptors suddenly the lack of dopamine in the transporter is even more effected and when I started back again on ritalin because of it been a reuptake inhibitor it has helped somewhat but not massive amounts like before invega and also been left handed and most parma drugs only tested on mostly right handed makes it even worse most drugs are designed for right handed brains. Plus ADHD people have massive chances or greater chance of getting Parkinson's.
Click to expand...
I hope you get better man, I don’t gain anything from others’ suffering. I believe you are genuine and tell the truth about your experience. I feel sorry for you, and hope the rest of us heal fully eventually
 
keepinghope said:
What’s everyone up to today ?
Click to expand...
I'm getting high watching Beevis and Butthead, then I'm going to go for a walk and a swim.

I'm laughing! It's so dumb! Teenaged boys really do be like that!

Speaking of stuff that makes me laugh, Rude Tales of Magic made me laugh in month 2. It's like if a looney-tunes flavored adult cartoon/alt comic was a DnD podcast. It's done by some friends who used to do improv together. Don't drink anything while you're listening to it, it will come out of your nose! I recommend listening to the mini series, Come at the King, first to see if it's your cup of tea. It's just as funny and less of a commitment since it's like 10 episodes or something idk.

I also really enjoyed Snapcube's fandubs and Monster Factory, even on invega. Anyone can go watch/listen to these right now.

I recommend fiction podcasts in general. They can be easier to follow than audiobooks and will help keep your imagination intact. My favorites are The Magnus Archives and Old Gods of Appalachia. Old Gods is a bit hard to follow right now though. Goodass cosmic horror podcasts.
 
I don't believe antipsychotics permanently sever connections between braincells. They block neurotransmitters. The neurotransmitters they block are serotonin and dopamine, and you still have 10% of your transmitters open. Sure the connection might not be quite right ever again, but it doesn't erase you! I can feel my brain reconnecting, I am getting parts of myself back!

And weather or not antipsychotics shrink the brain is actually a big 'ol ¯\_(ツ)_/¯ actually. The animal studies that "point" to it were influenced by the fact rats are placed on amphetamines to simulate schizophrenia, and meth is proven to shrink the brain. https://journals.sagepub.com/doi/full/10.1177/02698811221092252

I don't think you can kill a braincell just by blocking off serotonin and dopamine actually. They're always getting different neurotransmitters for stimulation.

This shit really scares people, it scares me. I'm trying to provide another perspective on this. Don't show me "evidence" to the contrary, it triggers my anxiety hardcore and makes me suicidal. Don't even respond to me, if you do I'm blocking. This is just what I think, and what I know about how medication and braincells work. At the end of the day we're all just people on the internet haunted by the medical mystery of how invega sustenna actually works and what it does to you. I don't think anyone knows the truth.

I just killed the good vibes by coming in here. I'm not going to log in again, I need to block this site on this browser.
 
Last edited:
I never used antipsychotics, i'm interested in dirtyinvega case. You have to make a distinction between functional plasticity and structural plasticity. That's what i did in my reply i also made a distinction in functional damage and structural damage. Also neuroplasticity is not some magic bullet, neurogenesis can heal and plasticity can increase function but they can also make you sick by forming wrong connections. Antipsychotics have both neurothropic and effects of atrophy in different brain regions

"While the decrease in synapse number reported in some studies (Roberts et al 1995) seems to be predominantly a consequence of neurotoxicity, it is also possible that haloperidol may reduce the synaptic activity of some connections, causing destabilization and withdrawal of synapses. Even though there is substantial evidence for neurotoxic effects of haloperidol in the striatum (Harrison 1999), decreased synapse number is also compatible with a pruning of synapses in response to suppressed activity in specific neuronal circuits."

Antipsychotic Drugs and Neuroplasticity: Insights into the Treatment and Neurobiology of Schizophrenia - PMC

This paper reviews the evidence that antipsychotic drugs induce neuroplasticity. We outline how the synaptic changes induced by the antipsychotic drug haloperidol may help our understanding of the mechanism of action of antipsychotic drugs in ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Like i said before in previous post (which you probably didn't read) the mechanism that causes symptoms doesn't have to be caused by for example loss of synapses or possibly neurons but by the process of rearrangement. The decreased synaps number is caused by supression of activity by blocking neurotransmitters. Less activity = increased synaps pruning.
 
Last edited:
Status
Not open for further replies.
Top