yes but it's still bad it blocks dopamine a lott
I study neurochemistry, biochemistry, chemistry and genetics.
Invega(
Paliperidone) deforms and blocks protein receptors of dopamine/hestamine/adrenaline/serotonine/endorphine and also other recepors which aren't listed because it affects them less. Deformed receptors will have much lower efficiency and can take time to be replaced.It makes your metabolism slower and also your glands will be affected because dopamine(and some other stuff which it blocks) is used in regulating colon and small intestine, heart muscles and pancreas. Because of that It can cause pain in pancreas area, stomach pain(small intestine is misdisgesting food because of less regulation from brain), chest pain (because of thinus and pancreas issues), it can also cause you go to pee very often because your liver is working in overdrive + your colon and bladder is not regulated properly by brain - because of that you can also get constipation. Your heart beat can get arythmic. You can get thyroid problems or adrenal gland problems which will increase your anger but invega would block those receptors responsible for adrenaline (you wont feel it) but your body would still feel it and that can cause urge to move. It causes other types of damage too.
Humans have different sizes of neurons and synapses, and different brain structures - this is reason why paliperidone can't reach some parts of brain for some people (and it is less effective on them - but paliperidone being non effective and not causing severe anhedonia is almost non existant) or when it causes passouts.
(This site shows lot of mechanism-s of action from Invega oral but not all of them):
Paliperidone is an atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders.
go.drugbank.com
Paliperidone effects on glands, digestive systems, heart, pancreas, liver and bladder are not acceptable and it is one of reasons for it to be banned.
Protein deforming is serious problem and such mechanisms of action from any drug should be banned.
Paliperidone has more than enough reasons to be removed and banned from market or at least removed and tested on healthy humans (which never had psyhosis, depression or mania) to see effects of it on human brain, glands, brain regulation of organs. Testing needs to be at least year long because of seriousness of the drug. Testing on mices and animals is not enough since they can't give proper response and their organism and metabolism is different + we have much more advanced and different brain. Mice who get paliperidone tried to starve to death.
People also need to be educated that anhedonia is not equal to depression. There are lot of people who say they are depressed when they take Invega and that they get anorgasmia (and because of that it is considered depressant drug but nobody talks about anhedonia which can be cause of depression and severe anhedonia is caused by Invega - one of most serious side-effects which should be on TOP of side-effects and not somewhere where nobody will find it) and lot of people consider depression is connected with saddness and its value is lessened because people consider that depression is mentaly induced while severe anhedonia can not be induced mentaly. This is why I never use depression as word alone but rather words like absence of emotion, absence of feeling experience, absence of reactions to stuff, etc - those stuff are more specific. Invega induced anhedonia and saddness until saddness is blocked too and turns into desperation which can look like saddness.