GucciSwimmingSuits
Greenlighter
- Joined
- Sep 10, 2017
- Messages
- 28
While I can't speak to the H-1 reaction, I would stay away from Grapefruits or their Juice when dealing with Codeine specifically. It can inhibit some of the CYP 450 enzymes responsible for converting the Methyl Morphine (codeine) to Morphine. Then there's the argument for codeine-6-glucuronide as well.
Yup, that's what I've seen other people say too. From what I understand codeine effects come from multiple different chemicals, so I guess in my case I blocked some of them and enhanced others. Also, it's important that your stomach is empty when you're drinking cwe and grapefruit juice is not only a liquid that takes up space in your stomach, it also usually has chunks of grapefruit flesh in there(and if you're drinking the gfj like 4-5 hours before the cwe it probably won't affect the enzymes much).
What would you say about taking antihistamines with codeine? I've asked this question a few times before and researched it on my own, but I still haven't found any real answers, should you take it before, after or at the same time as the cwe? I have slight acid reflux, so I'm especially sensitive as far as consuming anything orally. Last time I took it after and it didn't seem to work. Of course I'm not expecting it to have any magical effects, just a slight reduction of itchiness and some added sedation.