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Codeine Extraction

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If you're interested in a CYP2D6 inducer, St Johns Wort is one however it also induces CYP3A4, which you don't want. So combine it with a CYP3A4 inhibiter.
 
Mr Blonde said:
If you're interested in a CYP2D6 inducer, St Johns Wort is one however it also induces CYP3A4, which you don't want. So combine it with a CYP3A4 inhibiter.
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what would be a CYP3A4 inhibiter?
 
8o all these enzymes, and there strange namez!! can get confuzin.. will have to do my homework if im to be goin bak to colledge, bak out with the chemistry 4 beginnerz:|
i been chasin codiene wit grapefruit jc all tha time, damn SMFG get yo shit togetha..wasteful person
 
Honestly I think the answer is just use more opiates. Taking a stack of 50 different things is going to cost more then just taking more opiates anyway.

One thing I do agree with is anti histamines though, as they reduce itchyness, nausea and potentiate the opiates slightly. Anything more is just getting silly unless you are taking it for the synergy, eg alcohol and benzos.
 
what would be a CYP3A4 inhibiter?
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Most of the inhibitors I know are from hanging out in OD too much, and are OTC there but Rx here, e.g. Tagamet.

I recommend you look in the OD Directory for the link that 's called something like CYP3A4 enzyme inducers/inhibitors or something similar, then read through that for the CYP3A4 inhibitors and check them all out through Google, etc.

As rolls said, taking more may be easier. :\

OK now I really have to go get some sleep.

ETA: By 'there' I mean America, not OD where everything is OTC. ;)
 
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yeh taking more is good but i already aim for around 400mg which is the max level of effects for codeine. ah wells i enjoy my weekly dose anyway so dnt really need inhibitors or inducers
 
Try going over the ceiling dose just once to see what happens. I did it and it turned out that I quite enjoyed it and have been able to go WAY over the ceiling dose but that's another story.
 
Mr Blonde said:
To tadfish: I have seen soma recommended a few times as a potentiator by OD regulars, they say though that it may add to the sedation a fair bit so be careful.
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its what soma breaks down into check it out wikipedia

also i agree Mr Blonde u can go over and when u mix alot of potentators it does work plus i find if u spread your doses apart say 200-300mg then another 100mg later and then take more a few hours later works in think in 24 hours you can use i recon 1000mg.

Also just wondering about if anyone uses nurofen now days.
i also rinse my last stuff off and use that water for my next extract so i know i get less off what i don't want in water and makes sure i use it all.
i thinking now i mix nurofen CWE with panadeine CWE to give my liver a break and distrube the damage to the liver and kidneys instead off always using panadeine and stressing me liver.
also its like 1mg per mL soluble in water nurofen isn't it
so if u use the freeze the whole solution then i saw off the gunk layer then i defrose filter again and chill then drink
i do it a few times to get things nice and filter and frozzen and cold as much possible.
repeat rinse and always repeat. i like to freeze it a few times and rip off the bottom layer and always filter alot and keep it cold as and always use left overs to rinse and use that water for next time.
i don't even use hot water anymore unless i using those caplets or nurofen
 
I used 100ml of water on a 48 pack once, it sucked up the entire 100ml, just had this sludge that was barely even wet. Never wasted my money again, not only is it expensive they take your details down as well.
 
iv been takin to using one filter/collection glass for every 10 tabs, it seems to be quicker, and clearer filtrate, then squeeze each filter into a boowl to grab the little remaining liquid, refiltering that, then once the solids are out of the filter soakin them in another lil bit of water, just to be sure im gettin tha most goodness, when i filter a decent ammount all @ once it takes too long and i tend to get impatient, thats mostly when i see clouds:\
 
Mr Blonde said:
^ +1. Too sludgy/hard to break up as well.
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Yeah, whats the deal with this? I am very wary of using paracetemol as my liver is kinda fucked, so nurofen (or ibuprofen and codeine) is the way to go for me. But do I need like half a litre of water or something??? The tablets broke up okay; the mixture was watery, though with a fair bit of gunky paste; I just let it sit and drain though a singlet for a while. Incredibly bitter and mild effects. Shithouse....
 
Mr Blonde said:
Try going over the ceiling dose just once to see what happens. I did it and it turned out that I quite enjoyed it and have been able to go WAY over the ceiling dose but that's another story.
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My times with going over the 'ceiling dose' have also been positive. Although I feel a bit wary talking about it.

On the few times I have had 'higher' dosages, I will lay on the lazy boy, feel my breathing, and experience a semi-conscious "nod", not unlike being on sublingual opium. The feeling of 'now' perforated with a slight itch and harmony of the mind and body.

Sometime during the dopamine hue I get caught in a blissful slumber which feels more like a pure dream (n.b. it is personally hard to stay awake on high doses of codeine for more than say 30-60mins. I have found caffeine balances this lethargy respectably well) , and then maybe an hour later I will wake up to use the bathroom and be no doubt 'dazed' and 'confused'. This feeling becomes more pronouned when I haved attempted to stand/walk and I will feel definite "WAVES" of euphoria washing through my body, yet the general displacement of the mind renders this effect almost secondary, although, these "WAVES" have been pretty strong (you know the euphoria is there but you are too polaxed to appraciate it fully) and to the point at one stage that I was concerned my breathing was too shallow.

So yes, high doses of codeine work, and I am not a personal believer in the 'ceiling effect', or maybe my respective liver enzymes are abnormally abundant/efficient. Either way I do not see a point in taking large doses since there is a 90% chance you will just fall asleep. **Codeine (-> Morphine via liver) at these doses tend to lend more to their overtly depressive/analgesic capabilities** ie: would you want a mild dose so you can enjoy the subtle effects and still be in contact, or would you rather be 'completely numb'? I prefer the former.

KC signing off../
 
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Nice post, however I don't think your analogy of 'general anaesthetic' is on the mark; take your dose of codeine and find 10% of that to get the respective amount of morphine; people use that in big amounts without going into unconciousness, they just nod.

ETA: 'Large' because morphine's bioavailability is very poor. But people do tend to use bigger doses of morphine then codeine after you convert, if you follow.
 
Mr Blonde. said:
^ +1. Too sludgy/hard to break up as well.
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I haven't touched N+ since the day they became unsplittable. There's only one thing I hate more than paracetamol and thats ibuprofen, I don't want anything to do with it!
 
Well i got some N+ and filter them i recon it good to rotate between panadeine and N+ but yeah i haven't used it either since u could split them.
i wonder how much business they lost out on for that.
But i mostly use panadeine i using it every day now for a while.
wonder how my liver is have 600-1200mg of codeine a day with other stuff to potentate
 
tadfish said:
i recon it good to rotate between panadeine and N+
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Advocated this as safer practice on these boards a while back and didn't seem to go down too well with collective opinion. Don't know why not? I even go so far as to take aspirin/codeine mixes (Dispirin Forte & Aspalgin) sometimes as substitutes (or rather a part of an aggregated dose with paracetamol/ibuprofen) to break the pattern of harmful co-ingedients up; albeit aspirin is ofcourse soluble so CWE is ineffective yet will take 3 or 4 in some orange juice when seeking just small (30-40mg) quantities of codeine. What is everyone's opinion on this? Am I missing something?

PS: from the University chemist I managed to acquire a paracetamol/codeine mix with the ratio 10:500mg (more than mersyndol). Didn't know these existed. The brand name is simply 'Pharmacist'.

PPS: Was talking to the pharmacist today and asked about their views on codeine/dihydrocodeine products and the answer was that there is no standardised practise other than obvious 'regulations' and it is up to the 'store policy' as to how they distribute them.

(This is in Melbourne)

Food for thought :)
 
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N+

You guys know that N+ is well ibuprofen is less than 1mg per mL soluble in water, so good filter and cold water freeze i even cut the frozen ice block to get the bottom layer off theen defrost and filter and chill again
 
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