rolls said:If you dose over the threshold, what happens, does the codeine stick around (causing histamine release) until enzymes are free to convert it? or does another enzyme take over and convert it to something inactive?
Mr Blonde said:A few things might happen.
1) If you're like me, and have nice enzyme chemistry, you may get higher then you would at the ceiling dose.
2) If you're not like me, and have normal levels of CYP2D6 I assume, then yes you will have an increased histamine reaction and the codeine that doesn't get turned into morphine will be metabolized into something else; codeine-6-glucorinide I think. Some codeine remains as it is for a whilem making the histamine reaction first but it will probably end up being either excreted or being converted to C-6-G, not morphine as CYP2D6 is inhibited by codeine for a while.
andCodeine phosphate LD50 (oral) rat 266 mg/kg
From: http://www.inchem.org/documents/pims/pharm/codeine.htmAn evaluation of codeine intoxication in 430 children, reported the following symptoms in decreasing order of frequency: sedation, rash, miosis, vomiting, itching, ataxia, and swelling of the skin (oedema). Respiratory failure occurred in eight children, two of whom died; all eight had taken 5 mg/kg body weight or more.
atropine said:I took this picture to show the difference in water clarity between using
actual chemistry filter paper, and Harris Coffee Filter paper.
The clear solution is codeine extract with the chemistry filter paper. That shows that maybe using Coffee filters is not as healthy as you might think.
belarki said:3) Itchiness and nausea; not at all desirable
Mr Blonde said:Grapefruit juice will inhibit CYP2D6, which is the enzyme you want to convert codeine into morphine.
So GFJ + codeine would, if anything, lessen the effects. With other opioids, you are supposed to drink about 45 minutes before taking them. It works for any opioid metabolized by CYP3A4, but in all honesty it's not gonna do much.