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Codeine and CWE Megathread - The long awaited!

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So its something to with the classification of these antihistamines as 1st gen that qualifies them as ok to take before your codeine? Why is it some antihistamines wont prevent the codeine converting to morphine in the body but are still able to prevent itchiness/nausea etc?
 
Well as I couldn't be fucked looking it up myself and luckily my good friend Drug Mentor was on hand -

Antihistamines can stop itching and nausea by a pathway completely unrelated to the liver enzymes involved in the conversion of codeine to morphine. Anti histamines prevent the action of histamine - the chemical that causes itching. Some antihistamines interact with certain liver enzymes in a beneficial way, but this isn't actually because of a special property antihistamines as a whole, or even 1st gen antihistamines. Instead, 1st gen antihistamines are often considered more desirable because of the sedating effect.
 
Its sounds like youre saying that no antihistamines block the conversion of codeine into morphine... ? You arent saying that though right?
 
I think the pointis that an antihistamine stops the itching or nausea because that's what antihistamines generally do, it is not because it is stopping or slowing codeine to morphine conversion, that is an enzyme issue in the liver which is different. An antihistamine may slow or stop both itching AND conversion to morphine but they are totally distinct mechanisms, the latter probably being inhibition of cypd2d6 enzyme or w/e it is in the liver.
 
I once knew a guy named andyturbo. Who railed a travacalm to try and get high. He crushed it up on his bed, double checked it with ted. Then asked me to throw out his porn collection if he died.

True story.


Do you still need to take travacalm to counteract the nausea footsy? I mean after taking codeine for all this time.. I've found as tolerance go's up with opiates, the less chance you'll be subjected to the nausea when dosing at higher levels with opies.. go's up with opiates, the less chance you'll be subjected to the nausea when dosing at higher levels with opies..found as tolerance go's up with opiates, the less chance you'll be subjected to the nausea when dosing at higher levels with opies.. go's up with opiates, the less chance you'll be subjected to the nausea when dosing at higher levels with opies..
 
LOLLL! WTF happened to my post??

Thats why I don't like posting shit from my phone.. :|
 
Just use a minimal amount of DXM if u wanna potentiate the codeine, nufn OTC works better. Add a bit of buds to it and u have a very nice euphoric combo.
 
Its sounds like youre saying that no antihistamines block the conversion of codeine into morphine... ? You arent saying that though right?

No that wasn't what DM or I was saying, like mcwally said they're different mechanisms, anti histamines use is to conteract histamine, which causes the itching or nausea. As an additional property which has nothing to do with them being antihistamines, they may also inhibit or potentiate codeine, just like other chemicals that aren't anti histamines might inhibit or potentiate codeine.

Anyway, no unfortunately my nausea doesn't seem to have subsided at all! My tolerance to opiates also rises really slowly though, I think that probably has something to do with it.

In a way discovering anti histamines has been a curse because before that, I tried heroin a few times and was so naueseous I didn't try it or any other opiate again for years, and only enjoyed them when I realised I could take travacalm beforehand. Even now if I don't take a travacalm I'll have one burn of smack and feel so sick.
 
Yeah its all good dude. Was being a bit lazy yesterday... no excuse these days not to ctrl-tab over to Google and research whatever the fuck in less than a coupla mins.

Chalk it up to lazy sunday.

So has anyone here combined the codeine with temazepam? If so how did it compare to diazepam and/or alprazolam? There is some info about temazepam and opiates in the potentiation link posted earlier in the thread. Would be interested in hearing any more experiences and to get an idea of dosage. Assuming temaz is about half as potent as diaz Im thinking 20-40mg should do it.
 
Wow getting queezy stomach off codeine? I never get that off opiates. Never would have guessed codeine to even be strong enough to cause that.
 
Me either. The only time I ever suffered in that department was when I was being kinda naughty after they changed the n+ formula and they were no longer splittable. I didnt know about cwe or maybe I did but I someone got the idea that it was shit and didnt work properly. So like I said, I was being naughty, and my usual intake of p+/n+ was 12 full tablets with food (heaps of food) then a couple hours later 12 more with food. Sometimes Id even go a third intake of naughtiness.

Anyway I eventually discovered that if you eat a steak and follow that with a bunch of n+ pills your gut is gonna be all like "hey, fuck you!!!!" and hurl that shit back up. Nooooot pleasant at all... especially when you throw in a slight acid burn type sensation in the oesophagus most likely due to ibuprofen.

Yeah. Good times. Fuck you <insert Nurofens parent company here> for changing the splittable formula. I mean, seriously, just how fucking pointless was that when cwe is just so ridiculously easy, efficient and with an almost 100% codeine yield and Id hazard a guess <10% poison (apap/ibu/what-the-fuck-ever) remaining in the solution.
 
Works well the CWE, just a question for you all. I have been suffering migraines for most of my life, im nearly 35 and have taken many tablets in the past to help with pain, and yes Panadeine/Forte and Mersyndol Night are some i have taken. The worst thing with these codeine tablets is the drying up of your insides, codeine really dries you up and makes doing number 2's a big problem, my insides and mouth always feel like a desert. Does this not affect you guys? I know its a weird question but it always hurts my insides after alot of codeine.
 
yeh man it does the same to me, I think some are more susceptible than others to it. I'd say take some preventative stool softener/senna when you take codeine too. I use Coloxyl, think its sodium ducosate with senna, the latter slightly agitates the bowel muscles and ducosate gets a lil more water into the bowels/stool i think
 
tryin out dxm+codeine last time i think i had too much dxm (45ml or so) n felt weird only got like half of what i normaly take so need somthing to potainate it -_- think i'll try 20ml

In the furture should i use my DXM before after or at the same time as injesting the codeine?
 
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It's best to take it before, around 30 mins before, 20mls (60mg) max, but a booster ten-twenty minutes after you've ingested the codeine also seems to help - half the size, so 10ml (30mg) for example. I don't take dx with my codeine/opiates anymore because it gives me anxiety and a weird edge to my nod - instead of being a beautiful relaxing nod it's like the half asleep stage you get when you're feverish, where your thoughts go in loops and you can't get out of them properly.
 
As foots said, 30 min beforehand seems to work best for me.

45ml might be a bit much, I usually take enough to work out to 45 - 60mg, , 15 - 20ml or 1.5 - 2x the recommended medicinal dose.
 
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