Opioids cimetidine (tagamet) health issues?

[qwe]

so, after years of opiate potentiation, i finally happen to read the directions on the tagamet bottle%)

"do not take more than two tablets in a 24 hour period"

i'm wondering:

A) i've used large amounts of cimetidine for large stretches of time to make opiates more fun/cost-effective. could i have damaged my stomach? throat or intestine lining?
B) if so, how reversible is this, and how soon does it reverse? i've never had heartburn or anything
C) is there a ceiling dose? is taking more than a couple tablets totally unnecessary?
D) is there "rebound" stomach acidity which could also do damage?

 

[morphonorconic]

I've been wondering this myself, but have been unable to find any conclusive info on the topic. I've taken as much as 2000mg of Cimetidine (10 tablets) in a 12 hour period, and a few times I've done this for two or three days in a row.

I've never perceived any adverse effects, other than mild to moderate rebound acid reflux/stomach acidity. But I still wonder whether I could be causing some kind of damage.

So, I defintely notice some rebound acidity, but nothing too bad. I also feel that after six or so tablets I don't get any more appreciable (potentiation related) effects, but that's not to say there is in fact an actual ceiling.

 

[Depressicaa]

Okay you aren't saying how many mg you have taken. I think prescription wise, they go to 800mg, and usually OTC is 200mg. 400mg won't kill you, they just cover their asses.

 

[qwe]

up to 800mg at a time when i acquire opies. guess it's not too bad if it's prescribed at 800mg

 

[Volcano]

I thought they only potentiated benzos?

I take them every night with my benzos but only 1 pill. The Xanax leaflet says it increases B/A 86%.

I never feel 86% more fucked up, maybe 40% but still STRETCH THE DOLLARS

 

[Depressicaa]

I thought they only potentiated benzos?

I take them every night with my benzos but only 1 pill. The Xanax leaflet says it increases B/A 86%.

I never feel 86% more fucked up, maybe 40% but still STRETCH THE DOLLARS

They help all eaten meds.
Might make it more effective, but not more high, if you can understand what I mean.

 

[qwe]

this chart will let you know whether cimetidine potentiates a particular drug by way of the CYP enzyme in the liver, as well as many other drug-drug interactions

http://www.bluelight.ru/vb/showthread.php?t=191439

 

[blackjesus]

What cimetidine does, for label use, is unregulates the amount of T-cell's in your bloodstream that act on the "acid reflux" if im not mistaken. I have used cimetidine off label, with great results, for curing warts (in doses of 800mg and higher, daily for months at a time)

edit: on the wart issue, it works better than any wart medicine on the market (cream, saav, nitrogen freeze burn thing) it took about 2 months of daily use but nothing worked quite as well, and painless too, if you've ever had a wart and tried to remove it you know what im talking about...you cut them off they grow back, weird fucking things.

 

[NomNomNom]

Wow thanks for this thread and the knowledge/links in it. I've had that nagging "don't be a fucking moron, do some research before you start taking handfuls of tagamet" voice henpecking me the last few days

 

[NomNomNom]

I thought they only potentiated benzos?

I take them every night with my benzos but only 1 pill. The Xanax leaflet says it increases B/A 86%.

I never feel 86% more fucked up, maybe 40% but still STRETCH THE DOLLARS

If you like Vicodin, get prepared to fall back in LOVE with it! Cimetidine FTW!!!!11!

 

[qwe]

^ if anybody is newly coming upon this info,

and haven't already learned this lesson (lol..),

when you re-fall-in-love, keep the potentiation (cimetidine) to the weekends so it's sustainable, with your normal dose the weekdays

 

[Depressicaa]

This stuff I burn through unlike my baking soda. Baking soda did cause health problems for me, with all that sodium it had.